FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077736089> ?p ?o ?g. }

• W2077736089 abstract "Attempts at improving the efficacy of 5-fluorouracil (5-FU) by protracted continuous infusion and/or biochemical modulation have been hindered by the need for indwelling central venous catheters and their associated toxicity. Capecitabine, an oral fluoropyrimidine carbamate, has been rationally synthesized as an inactive precursor that is absorbed intact through the intestinal mucosa and is sequentially converted by an enzymatic cascade involving 3 distinct enzymes to 5'-deoxy-5-fluorocytidine, to 5'-deoxy-5-fluorouridine (5'-DFUR), and finally to 5-FU. Preclinical studies provided evidence of preferential intratumoral conversion of inactive 5'-DFUR to active 5-FU due to the relative overexpression of the final anabolizing enzyme, thymidine phosphorylase, in tumor tissues, with a resultant decrease of 5-FU exposure in normal tissues. The safety of capecitabine and optimal dosing schedules have been explored in phase I/II studies, resulting in the evaluation of the intermittent schedule (1250 mg/m2 twice daily for 14 days, every 3 weeks) in most subsequent clinical trials. Two large randomized phase III studies in patients with metastatic colon cancer established at least equivalent efficacy and improved tolerability with capecitabine compared to the Mayo Clinic bolus 5-FU/leucovorin regimen. The most common treatment-related adverse events are palmar-plantar erythrodysesthesia, diarrhea, and stomatitis, with grade 3/4 events occurring in 17%, 15%, and 2%-8% of patients, respectively. Myelosuppression was minimal. Overall toxicity was easily managed, with a significant reduction in the frequency of hospitalizations and medical resource use. The spectrum of clinical efficacy of capecitabine is expected to encompass other tumor types and administration in the adjuvant setting. As a home-based outpatient regimen, capecitabine represents a safe and effective advance in modern drug development." @default.
• W2077736089 created "2016-06-24" @default.
• W2077736089 creator A5015437737 @default.
• W2077736089 creator A5021317857 @default.
• W2077736089 date "2002-05-01" @default.
• W2077736089 modified "2023-09-27" @default.
• W2077736089 title "Capecitabine (Xeloda®): From the Laboratory to the Patient's Home" @default.
• W2077736089 cites W1525210877 @default.
• W2077736089 cites W1530403388 @default.
• W2077736089 cites W1571748472 @default.
• W2077736089 cites W1742102714 @default.
• W2077736089 cites W1773171357 @default.
• W2077736089 cites W1849818006 @default.
• W2077736089 cites W1905936368 @default.
• W2077736089 cites W1910716144 @default.
• W2077736089 cites W1919810009 @default.
• W2077736089 cites W1934919277 @default.
• W2077736089 cites W1941365207 @default.
• W2077736089 cites W1964749028 @default.
• W2077736089 cites W1980762644 @default.
• W2077736089 cites W2006271273 @default.
• W2077736089 cites W2025942655 @default.
• W2077736089 cites W2030395635 @default.
• W2077736089 cites W2035384960 @default.
• W2077736089 cites W2044970916 @default.
• W2077736089 cites W2055218751 @default.
• W2077736089 cites W2055977724 @default.
• W2077736089 cites W2057363667 @default.
• W2077736089 cites W2082669284 @default.
• W2077736089 cites W2086961710 @default.
• W2077736089 cites W2095181507 @default.
• W2077736089 cites W2097906802 @default.
• W2077736089 cites W2103221219 @default.
• W2077736089 cites W2109218307 @default.
• W2077736089 cites W2110617366 @default.
• W2077736089 cites W2121368761 @default.
• W2077736089 cites W2132508485 @default.
• W2077736089 cites W2133615960 @default.
• W2077736089 cites W2137194656 @default.
• W2077736089 cites W2138577761 @default.
• W2077736089 cites W2154669605 @default.
• W2077736089 cites W2155421004 @default.
• W2077736089 cites W2170524246 @default.
• W2077736089 cites W2314927739 @default.
• W2077736089 cites W2396646859 @default.
• W2077736089 cites W2409031629 @default.
• W2077736089 cites W2421222314 @default.
• W2077736089 cites W2602544133 @default.
• W2077736089 doi "https://doi.org/10.3816/ccc.2002.n.007" @default.
• W2077736089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12453332" @default.
• W2077736089 hasPublicationYear "2002" @default.
• W2077736089 type Work @default.
• W2077736089 sameAs 2077736089 @default.
• W2077736089 citedByCount "8" @default.
• W2077736089 countsByYear W20777360892012 @default.
• W2077736089 countsByYear W20777360892013 @default.
• W2077736089 countsByYear W20777360892014 @default.
• W2077736089 countsByYear W20777360892017 @default.
• W2077736089 countsByYear W20777360892020 @default.
• W2077736089 crossrefType "journal-article" @default.
• W2077736089 hasAuthorship W2077736089A5015437737 @default.
• W2077736089 hasAuthorship W2077736089A5021317857 @default.
• W2077736089 hasConcept C121608353 @default.
• W2077736089 hasConcept C126322002 @default.
• W2077736089 hasConcept C143998085 @default.
• W2077736089 hasConcept C197934379 @default.
• W2077736089 hasConcept C2776694085 @default.
• W2077736089 hasConcept C2776735402 @default.
• W2077736089 hasConcept C2777288759 @default.
• W2077736089 hasConcept C2777909004 @default.
• W2077736089 hasConcept C2778375690 @default.
• W2077736089 hasConcept C2779051857 @default.
• W2077736089 hasConcept C2780456651 @default.
• W2077736089 hasConcept C2781413609 @default.
• W2077736089 hasConcept C29730261 @default.
• W2077736089 hasConcept C526805850 @default.
• W2077736089 hasConcept C71924100 @default.
• W2077736089 hasConcept C90924648 @default.
• W2077736089 hasConcept C98274493 @default.
• W2077736089 hasConceptScore W2077736089C121608353 @default.
• W2077736089 hasConceptScore W2077736089C126322002 @default.
• W2077736089 hasConceptScore W2077736089C143998085 @default.
• W2077736089 hasConceptScore W2077736089C197934379 @default.
• W2077736089 hasConceptScore W2077736089C2776694085 @default.
• W2077736089 hasConceptScore W2077736089C2776735402 @default.
• W2077736089 hasConceptScore W2077736089C2777288759 @default.
• W2077736089 hasConceptScore W2077736089C2777909004 @default.
• W2077736089 hasConceptScore W2077736089C2778375690 @default.
• W2077736089 hasConceptScore W2077736089C2779051857 @default.
• W2077736089 hasConceptScore W2077736089C2780456651 @default.
• W2077736089 hasConceptScore W2077736089C2781413609 @default.
• W2077736089 hasConceptScore W2077736089C29730261 @default.
• W2077736089 hasConceptScore W2077736089C526805850 @default.
• W2077736089 hasConceptScore W2077736089C71924100 @default.
• W2077736089 hasConceptScore W2077736089C90924648 @default.
• W2077736089 hasConceptScore W2077736089C98274493 @default.
• W2077736089 hasLocation W20777360891 @default.
• W2077736089 hasLocation W20777360892 @default.
• W2077736089 hasOpenAccess W2077736089 @default.
• W2077736089 hasPrimaryLocation W20777360891 @default.

• next