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• W2077736812 abstract "ABSTRACT The insertion of a heterologous gene into commensal bacteria is a common technique to develop a delivery agent for vaccination and therapies, but the pleiotropic effects of genetic modifications need to be investigated before its use in practical applications. Although supplemental properties provided by the expression of heterologous antigens have been reported, the negative or side effects on the immune-modulating properties caused by recombination are barely understood. In the present study, we fortuitously found that the secretion of tumor necrosis factor alpha (TNF-α) from murine macrophages was reduced by recombinant Lactobacillus casei expressing Salmonella OmpC compared to the stimulation of TNF-α secretion by nonexpressing L. casei . This reduction could not be attributed to OmpC as a purified protein. The main component of the OmpC-expressing strain included in the attenuation of TNF-α release seemed to be the cell wall, which exhibited higher sensitivity against N -acetylmuramidase than that of nonexpressing strains. These results suggest that the recombinant strain expressing a specific heterologous antigen might be digested rapidly in macrophages and lose immune-stimulating capability at an early time point." @default.
• W2077736812 created "2016-06-24" @default.
• W2077736812 creator A5005721800 @default.
• W2077736812 creator A5068944397 @default.
• W2077736812 date "2009-05-01" @default.
• W2077736812 modified "2023-10-18" @default.
• W2077736812 title "Reduction of Tumor Necrosis Factor Alpha-Inducing Capacity of Recombinant Lactobacillus casei via Expression of Salmonella OmpC" @default.
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• W2077736812 doi "https://doi.org/10.1128/aem.01916-08" @default.
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