FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077741572> ?p ?o ?g. }

• W2077741572 abstract "We have synthesized and characterized a series of novel derivatives of established antagonists of the neurotransmitter dopamine, i.e. butyrophenones, hexahydrocarbolines and phenothiazines. All derivatives were biotinylated, some of them carried an additional (photoactivatable) azido group. In the case of butyrophenones, the structural modifications were introduced at the aliphatic keto group and/or the heterocyclic ring system, both modifications resulting in significant decreases in binding affinity to dopamine D2 and dopamine D1 receptor subtypes. Biotinylation of hexahydrocarbolines significantly increased their binding affinity to D1 receptors, with the affinity for D2 receptors increasing only slightly, or remaining approximately the same, as compared to the parent compound. As a consequence, the derivatized hexahydrocarbolines behaved as nonselective antagonists of dopamine. Biotinylation of phenothiazines increased their binding affinity to both main subtypes of dopamine receptors by at least one order of magnitude, resulting in binding affinities in the nM range. These derivatives bound to both D1 and D2 receptor subtypes. In three of the biotinylated derivatives the photoactivatable azido group was introduced. These compounds bound to synaptosomal membranes from bovine caudate nuclei with similar affinity and subtype specificity as the biotinylated derivatives, and photoaffinity labelling was shown to proceed under mild conditions and selectively. These novel bifunctional ligands may become useful tools in the purification and characterization of dopamine receptors including their visualization and localization in the central nervous system and in tissue culture." @default.
• W2077741572 created "2016-06-24" @default.
• W2077741572 creator A5041706713 @default.
• W2077741572 creator A5074867425 @default.
• W2077741572 date "1992-06-01" @default.
• W2077741572 modified "2023-10-18" @default.
• W2077741572 title "Synthesis and characterization of biotinylated and photoactivatable neuroleptics. Novel bifunctional probes for dopamine receptors" @default.
• W2077741572 cites W1510793262 @default.
• W2077741572 cites W1536131202 @default.
• W2077741572 cites W1548579074 @default.
• W2077741572 cites W1587028629 @default.
• W2077741572 cites W1673680248 @default.
• W2077741572 cites W1775749144 @default.
• W2077741572 cites W1884206649 @default.
• W2077741572 cites W1955225173 @default.
• W2077741572 cites W1966092598 @default.
• W2077741572 cites W1967698757 @default.
• W2077741572 cites W1974600573 @default.
• W2077741572 cites W1975061094 @default.
• W2077741572 cites W1978850926 @default.
• W2077741572 cites W1989667388 @default.
• W2077741572 cites W2001566515 @default.
• W2077741572 cites W2006548681 @default.
• W2077741572 cites W2012775731 @default.
• W2077741572 cites W2015907077 @default.
• W2077741572 cites W2017549779 @default.
• W2077741572 cites W2026339353 @default.
• W2077741572 cites W2040777203 @default.
• W2077741572 cites W2040883320 @default.
• W2077741572 cites W2042437346 @default.
• W2077741572 cites W2043393596 @default.
• W2077741572 cites W2043813981 @default.
• W2077741572 cites W2046572235 @default.
• W2077741572 cites W2052444330 @default.
• W2077741572 cites W2053234111 @default.
• W2077741572 cites W2054533778 @default.
• W2077741572 cites W2059230444 @default.
• W2077741572 cites W2062751984 @default.
• W2077741572 cites W2064121091 @default.
• W2077741572 cites W2065241932 @default.
• W2077741572 cites W2069062297 @default.
• W2077741572 cites W2082399534 @default.
• W2077741572 cites W2083583704 @default.
• W2077741572 cites W2095078357 @default.
• W2077741572 cites W2119478024 @default.
• W2077741572 cites W2201159645 @default.
• W2077741572 cites W2317705625 @default.
• W2077741572 cites W2328450472 @default.
• W2077741572 doi "https://doi.org/10.1016/0922-4106(92)90171-q" @default.
• W2077741572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1353449" @default.
• W2077741572 hasPublicationYear "1992" @default.
• W2077741572 type Work @default.
• W2077741572 sameAs 2077741572 @default.
• W2077741572 citedByCount "1" @default.
• W2077741572 crossrefType "journal-article" @default.
• W2077741572 hasAuthorship W2077741572A5041706713 @default.
• W2077741572 hasAuthorship W2077741572A5074867425 @default.
• W2077741572 hasConcept C120069818 @default.
• W2077741572 hasConcept C156927020 @default.
• W2077741572 hasConcept C161790260 @default.
• W2077741572 hasConcept C169760540 @default.
• W2077741572 hasConcept C170493617 @default.
• W2077741572 hasConcept C185592680 @default.
• W2077741572 hasConcept C204628709 @default.
• W2077741572 hasConcept C2780443040 @default.
• W2077741572 hasConcept C44208683 @default.
• W2077741572 hasConcept C513476851 @default.
• W2077741572 hasConcept C55493867 @default.
• W2077741572 hasConcept C71240020 @default.
• W2077741572 hasConcept C86803240 @default.
• W2077741572 hasConceptScore W2077741572C120069818 @default.
• W2077741572 hasConceptScore W2077741572C156927020 @default.
• W2077741572 hasConceptScore W2077741572C161790260 @default.
• W2077741572 hasConceptScore W2077741572C169760540 @default.
• W2077741572 hasConceptScore W2077741572C170493617 @default.
• W2077741572 hasConceptScore W2077741572C185592680 @default.
• W2077741572 hasConceptScore W2077741572C204628709 @default.
• W2077741572 hasConceptScore W2077741572C2780443040 @default.
• W2077741572 hasConceptScore W2077741572C44208683 @default.
• W2077741572 hasConceptScore W2077741572C513476851 @default.
• W2077741572 hasConceptScore W2077741572C55493867 @default.
• W2077741572 hasConceptScore W2077741572C71240020 @default.
• W2077741572 hasConceptScore W2077741572C86803240 @default.
• W2077741572 hasLocation W20777415721 @default.
• W2077741572 hasLocation W20777415722 @default.
• W2077741572 hasOpenAccess W2077741572 @default.
• W2077741572 hasPrimaryLocation W20777415721 @default.
• W2077741572 hasRelatedWork W1995920510 @default.
• W2077741572 hasRelatedWork W2019708552 @default.
• W2077741572 hasRelatedWork W2030683825 @default.
• W2077741572 hasRelatedWork W2040883320 @default.
• W2077741572 hasRelatedWork W2083097367 @default.
• W2077741572 hasRelatedWork W2116174501 @default.
• W2077741572 hasRelatedWork W2122991783 @default.
• W2077741572 hasRelatedWork W2410328244 @default.
• W2077741572 hasRelatedWork W2418020465 @default.
• W2077741572 hasRelatedWork W2506448155 @default.
• W2077741572 isParatext "false" @default.
• W2077741572 isRetracted "false" @default.
• W2077741572 magId "2077741572" @default.

• next