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• W2077745487 abstract "Spatial Independent Component Analysis (ICA) is an increasingly used data-driven method to analyze functional Magnetic Resonance Imaging (fMRI) data. To date, it has been used to extract sets of mutually correlated brain regions without prior information on the time course of these regions. Some of these sets of regions, interpreted as functional networks, have recently been used to provide markers of brain diseases and open the road to paradigm-free population comparisons. Such group studies raise the question of modeling subject variability within ICA: how can the patterns representative of a group be modeled and estimated via ICA for reliable inter-group comparisons? In this paper, we propose a hierarchical model for patterns in multi-subject fMRI datasets, akin to mixed-effect group models used in linear-model-based analysis. We introduce an estimation procedure, CanICA (Canonical ICA), based on i) probabilistic dimension reduction of the individual data, ii) canonical correlation analysis to identify a data subspace common to the group iii) ICA-based pattern extraction. In addition, we introduce a procedure based on cross-validation to quantify the stability of ICA patterns at the level of the group. We compare our method with state-of-the-art multi-subject fMRI ICA methods and show that the features extracted using our procedure are more reproducible at the group level on two datasets of 12 healthy controls: a resting-state and a functional localizer study." @default.
• W2077745487 created "2016-06-24" @default.
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• W2077745487 date "2010-05-01" @default.
• W2077745487 modified "2023-10-13" @default.
• W2077745487 title "A group model for stable multi-subject ICA on fMRI datasets" @default.
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• W2077745487 doi "https://doi.org/10.1016/j.neuroimage.2010.02.010" @default.
• W2077745487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20153834" @default.
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