Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077752983> ?p ?o ?g. }
- W2077752983 endingPage "e1443" @default.
- W2077752983 startingPage "e1443" @default.
- W2077752983 abstract "Myocyte enhancer factor 2 protein (Mef2) is an evolutionarily conserved activator of transcription that is critical to induce and control complex processes in myogenesis and neurogenesis in vertebrates and insects, and osteogenesis in vertebrates. In Drosophila, Mef2 null mutants are unable to produce differentiated muscle cells, and in vertebrates, Mef2 mutants are embryonic lethal. Schistosome worms are responsible for over 200 million cases of schistosomiasis globally, but little is known about early development of schistosome parasites after infecting a vertebrate host. Understanding basic schistosome development could be crucial to delineating potential drug targets. Here, we identify and characterize Mef2 from the schistosome worm Schistosoma mansoni (SmMef2). We initially identified SmMef2 as a homolog to the yeast Mef2 homolog, Resistance to Lethality of MKK1P386 overexpression (Rlm1), and we show that SmMef2 is homologous to conserved Mef2 family proteins. Using a genetics approach, we demonstrate that SmMef2 is a transactivator that can induce transcription of four separate heterologous reporter genes by yeast one-hybrid analysis. We also show that Mef2 is expressed during several stages of schistosome development by quantitative PCR and that it can bind to conserved Mef2 DNA consensus binding sequences." @default.
- W2077752983 created "2016-06-24" @default.
- W2077752983 creator A5016766338 @default.
- W2077752983 creator A5017338860 @default.
- W2077752983 date "2012-01-03" @default.
- W2077752983 modified "2023-09-23" @default.
- W2077752983 title "Identification and Characterization of a Mef2 Transcriptional Activator in Schistosome Parasites" @default.
- W2077752983 cites W1531038186 @default.
- W2077752983 cites W1573365260 @default.
- W2077752983 cites W1635421292 @default.
- W2077752983 cites W1763161027 @default.
- W2077752983 cites W1947596099 @default.
- W2077752983 cites W1970078620 @default.
- W2077752983 cites W1972001315 @default.
- W2077752983 cites W1978455300 @default.
- W2077752983 cites W1988642111 @default.
- W2077752983 cites W1988877850 @default.
- W2077752983 cites W1995068530 @default.
- W2077752983 cites W1999824463 @default.
- W2077752983 cites W2009972857 @default.
- W2077752983 cites W2011182719 @default.
- W2077752983 cites W2013061140 @default.
- W2077752983 cites W2013376464 @default.
- W2077752983 cites W2016150993 @default.
- W2077752983 cites W2020672093 @default.
- W2077752983 cites W2026579495 @default.
- W2077752983 cites W2026808195 @default.
- W2077752983 cites W2029903395 @default.
- W2077752983 cites W2030436637 @default.
- W2077752983 cites W2032117740 @default.
- W2077752983 cites W2034351801 @default.
- W2077752983 cites W2036343428 @default.
- W2077752983 cites W2042254824 @default.
- W2077752983 cites W2044702738 @default.
- W2077752983 cites W2047810769 @default.
- W2077752983 cites W2053916284 @default.
- W2077752983 cites W2057845770 @default.
- W2077752983 cites W2069724690 @default.
- W2077752983 cites W2070293940 @default.
- W2077752983 cites W2078422108 @default.
- W2077752983 cites W2078850134 @default.
- W2077752983 cites W2079994285 @default.
- W2077752983 cites W2084337315 @default.
- W2077752983 cites W2089204174 @default.
- W2077752983 cites W2091154357 @default.
- W2077752983 cites W2096459163 @default.
- W2077752983 cites W2097672164 @default.
- W2077752983 cites W2100536288 @default.
- W2077752983 cites W2102003203 @default.
- W2077752983 cites W2106468261 @default.
- W2077752983 cites W2107553595 @default.
- W2077752983 cites W2107844605 @default.
- W2077752983 cites W2113270134 @default.
- W2077752983 cites W2116631863 @default.
- W2077752983 cites W2119932644 @default.
- W2077752983 cites W2121504011 @default.
- W2077752983 cites W2121699212 @default.
- W2077752983 cites W2122967431 @default.
- W2077752983 cites W2123621585 @default.
- W2077752983 cites W2124013207 @default.
- W2077752983 cites W2127634027 @default.
- W2077752983 cites W2129004226 @default.
- W2077752983 cites W2132753699 @default.
- W2077752983 cites W2137015675 @default.
- W2077752983 cites W2139074887 @default.
- W2077752983 cites W2141131858 @default.
- W2077752983 cites W2147598480 @default.
- W2077752983 cites W2150681906 @default.
- W2077752983 cites W2152103266 @default.
- W2077752983 cites W2156999640 @default.
- W2077752983 cites W2157065916 @default.
- W2077752983 cites W2160950853 @default.
- W2077752983 cites W2165724034 @default.
- W2077752983 cites W2166322587 @default.
- W2077752983 cites W2169150541 @default.
- W2077752983 cites W2171966030 @default.
- W2077752983 cites W2174727521 @default.
- W2077752983 cites W4211120517 @default.
- W2077752983 doi "https://doi.org/10.1371/journal.pntd.0001443" @default.
- W2077752983 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3250504" @default.
- W2077752983 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22235355" @default.
- W2077752983 hasPublicationYear "2012" @default.
- W2077752983 type Work @default.
- W2077752983 sameAs 2077752983 @default.
- W2077752983 citedByCount "5" @default.
- W2077752983 countsByYear W20777529832013 @default.
- W2077752983 countsByYear W20777529832014 @default.
- W2077752983 countsByYear W20777529832017 @default.
- W2077752983 countsByYear W20777529832023 @default.
- W2077752983 crossrefType "journal-article" @default.
- W2077752983 hasAuthorship W2077752983A5016766338 @default.
- W2077752983 hasAuthorship W2077752983A5017338860 @default.
- W2077752983 hasBestOaLocation W20777529831 @default.
- W2077752983 hasConcept C104317684 @default.
- W2077752983 hasConcept C111936080 @default.
- W2077752983 hasConcept C51183755 @default.
- W2077752983 hasConcept C54355233 @default.
- W2077752983 hasConcept C86339819 @default.