Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077753808> ?p ?o ?g. }
- W2077753808 endingPage "12" @default.
- W2077753808 startingPage "1" @default.
- W2077753808 abstract "Inhaled beta(2)-adrenoceptor agonists are by far the most effective and safe bronchodilators currently available. They have not been surpassed by any other bronchodilating principle. The way to this position has been long and started with the first successful treatment of acute, severe asthma with s.c. injections of adrenaline 100 years ago. Over the years, synthetic congeners of adrenaline have been produced and tested for their pharmacological properties. During the first decades, little attention was given airway smooth muscle. The discovery of isoprenaline in 1940 was the first major step towards selective bronchodilation. This compound became a key tool for the classification of adrenoceptors into alpha and beta. Salbutamol and terbutaline were the first to show a significant attenuation of the cardiostimulant effect and confirmed the subdivision of beta-adrenoceptors into beta(1) and beta(2). Much effort was made to eliminate the next dose-limiting side effect, skeletal muscle tremor but in vain. Prolonged duration of action was achieved in three ways: with bambuterol, an orally active carbamate ester prodrug of terbutaline, salmeterol, an inhaled beta(2)-adrenoceptor agonist emerging from a purposeful research project, and formoterol which was found, accidentally, to have a long duration of action when inhaled. Throughout the 20th century, beta-adrenoceptor agonists have been developed and marketed as racemates. The pharmacological activity usually resides in the (R)-enantiomer. Despite claims for the opposite, there is so far no compelling evidence that the presence of the less active (S)-enantiomer is of any harm to the patient. One hundred years of experience of structural modifications of adrenaline has shown that the possibilities to modify the properties of this endogenous prototype appear to be unlimited." @default.
- W2077753808 created "2016-06-24" @default.
- W2077753808 creator A5075277518 @default.
- W2077753808 date "2002-06-01" @default.
- W2077753808 modified "2023-10-03" @default.
- W2077753808 title "β-Adrenoceptor agonists and asthma—100 years of development" @default.
- W2077753808 cites W131737079 @default.
- W2077753808 cites W1481113965 @default.
- W2077753808 cites W1498136500 @default.
- W2077753808 cites W1503588437 @default.
- W2077753808 cites W1563992332 @default.
- W2077753808 cites W1961532221 @default.
- W2077753808 cites W1963637335 @default.
- W2077753808 cites W1965278426 @default.
- W2077753808 cites W1968408828 @default.
- W2077753808 cites W1968756999 @default.
- W2077753808 cites W1970005516 @default.
- W2077753808 cites W1970926642 @default.
- W2077753808 cites W1973148624 @default.
- W2077753808 cites W1974582464 @default.
- W2077753808 cites W1977191680 @default.
- W2077753808 cites W1984823259 @default.
- W2077753808 cites W1987062528 @default.
- W2077753808 cites W1990512101 @default.
- W2077753808 cites W1990951259 @default.
- W2077753808 cites W1995516548 @default.
- W2077753808 cites W1996285670 @default.
- W2077753808 cites W1996972993 @default.
- W2077753808 cites W1997605246 @default.
- W2077753808 cites W1998868963 @default.
- W2077753808 cites W2006785761 @default.
- W2077753808 cites W2008290399 @default.
- W2077753808 cites W2008805781 @default.
- W2077753808 cites W2011171358 @default.
- W2077753808 cites W2014333147 @default.
- W2077753808 cites W2014395382 @default.
- W2077753808 cites W2015175424 @default.
- W2077753808 cites W2016083298 @default.
- W2077753808 cites W2016125879 @default.
- W2077753808 cites W2017333235 @default.
- W2077753808 cites W2020622509 @default.
- W2077753808 cites W2022551713 @default.
- W2077753808 cites W2022611966 @default.
- W2077753808 cites W2023335735 @default.
- W2077753808 cites W2025921150 @default.
- W2077753808 cites W2026338485 @default.
- W2077753808 cites W2027552024 @default.
- W2077753808 cites W2030949242 @default.
- W2077753808 cites W2032263266 @default.
- W2077753808 cites W2032414191 @default.
- W2077753808 cites W2033708910 @default.
- W2077753808 cites W2034108509 @default.
- W2077753808 cites W2035528932 @default.
- W2077753808 cites W2036804833 @default.
- W2077753808 cites W2038291955 @default.
- W2077753808 cites W2041101189 @default.
- W2077753808 cites W2044125094 @default.
- W2077753808 cites W2044146611 @default.
- W2077753808 cites W2044733405 @default.
- W2077753808 cites W2045239229 @default.
- W2077753808 cites W2045408966 @default.
- W2077753808 cites W2045748290 @default.
- W2077753808 cites W2047451898 @default.
- W2077753808 cites W2050875367 @default.
- W2077753808 cites W2051645313 @default.
- W2077753808 cites W2055022390 @default.
- W2077753808 cites W2055386446 @default.
- W2077753808 cites W2055515484 @default.
- W2077753808 cites W2060844945 @default.
- W2077753808 cites W2061128767 @default.
- W2077753808 cites W2062687464 @default.
- W2077753808 cites W2064548705 @default.
- W2077753808 cites W2067568851 @default.
- W2077753808 cites W2068917688 @default.
- W2077753808 cites W2069708173 @default.
- W2077753808 cites W2076825739 @default.
- W2077753808 cites W2077621203 @default.
- W2077753808 cites W2079226836 @default.
- W2077753808 cites W2082273266 @default.
- W2077753808 cites W2082377180 @default.
- W2077753808 cites W2082475283 @default.
- W2077753808 cites W2083850374 @default.
- W2077753808 cites W2087093874 @default.
- W2077753808 cites W2087474459 @default.
- W2077753808 cites W2088752137 @default.
- W2077753808 cites W2090060450 @default.
- W2077753808 cites W2090115123 @default.
- W2077753808 cites W2093096189 @default.
- W2077753808 cites W2093564940 @default.
- W2077753808 cites W2102367111 @default.
- W2077753808 cites W2112074549 @default.
- W2077753808 cites W2128460207 @default.
- W2077753808 cites W2130897043 @default.
- W2077753808 cites W2133175022 @default.
- W2077753808 cites W2134111859 @default.
- W2077753808 cites W2136595445 @default.
- W2077753808 cites W2139099862 @default.
- W2077753808 cites W2147598713 @default.