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- W2077760008 abstract "In patients with uncontrolled diabetes mellitus, a markedly reduced fraction of thyroxine (T4) turnover is metabolized via the monodeiodinative pathways as compared to that of the normal subjects. The hypothesis that this lower deiodinating activity in the diabetic subjects is due to a lower tissue concentration of reduced glutathione was tested in rats treated with streptozotocin. The total and nonprotein sulfhydryls were measured in the liver, kidney, brain, heart and skeletal muscle. There was no difference between the tissue sulfhydryl concentrations of the normal animals and the animals made hyperglycemic for three and seven days. The net rate of 3,5,3′-triiodothyronine (T3) production from added T4 was measured in liver homogenates prepared from normal and diabetic animals. Despite the addition of dithioerythritol to all liver prepatrations, the T3 production rate was lower (P 0.02) in the diabet animal groups as compared to the control group. These findings suggest that the tissue concentration of nonprotein sulfhydryls is not a major factor in the reduced T3 production from T4 in diabetes mellitus." @default.
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- W2077760008 date "1981-04-01" @default.
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- W2077760008 title "The effects of diabetes mellitus on the 3,5,3′-triiodothyronine production" @default.
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- W2077760008 doi "https://doi.org/10.1016/0024-3205(81)90338-6" @default.
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