Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077761502> ?p ?o ?g. }
- W2077761502 endingPage "17728" @default.
- W2077761502 startingPage "17720" @default.
- W2077761502 abstract "Calcium- and voltage-gated (BK) K+ channels encoded by Slo1 play an essential role in nervous systems. Although it shares many common features with voltage-dependent KV channels, the BK channel exhibits differences in gating and inactivation. Using a mutant in which FWI replaces three residues (FIW) in the NH2 terminus of wild-type β2-subunits, in conjunction with alanine-scanning mutagenesis of the Slo1 S6 segment, we identify that the NH2 terminus of β2-subunits interacts with the residues near the cytosolic superficial mouth of BK channels during inactivation. The cytosolic blockers did not share the sites with NH2 terminus of β2-subunits. A novel blocking-inactivating scheme was proposed to account for the observed non-competition inactivation. Our results also suggest that the residue Ile-323 plays a dual role in interacting with the NH2 terminus of β2-subunits and modulating the gating of BK channels." @default.
- W2077761502 created "2016-06-24" @default.
- W2077761502 creator A5024998766 @default.
- W2077761502 creator A5026868216 @default.
- W2077761502 creator A5030388070 @default.
- W2077761502 creator A5036314525 @default.
- W2077761502 creator A5049982649 @default.
- W2077761502 creator A5065859286 @default.
- W2077761502 creator A5066857412 @default.
- W2077761502 creator A5070000402 @default.
- W2077761502 creator A5077303230 @default.
- W2077761502 creator A5080236801 @default.
- W2077761502 date "2007-06-01" @default.
- W2077761502 modified "2023-10-16" @default.
- W2077761502 title "Interaction Sites between the Slo1 Pore and the NH2 Terminus of the β2 Subunit, Probed with a Three-residue Sensor" @default.
- W2077761502 cites W1517714742 @default.
- W2077761502 cites W1530607424 @default.
- W2077761502 cites W1560867685 @default.
- W2077761502 cites W1587611015 @default.
- W2077761502 cites W1886320289 @default.
- W2077761502 cites W1964501667 @default.
- W2077761502 cites W1966667742 @default.
- W2077761502 cites W1974997331 @default.
- W2077761502 cites W1977127647 @default.
- W2077761502 cites W1988862158 @default.
- W2077761502 cites W1992319989 @default.
- W2077761502 cites W2002189059 @default.
- W2077761502 cites W2005178989 @default.
- W2077761502 cites W2014158880 @default.
- W2077761502 cites W2035962429 @default.
- W2077761502 cites W2042183734 @default.
- W2077761502 cites W2051628563 @default.
- W2077761502 cites W2059957319 @default.
- W2077761502 cites W2063845237 @default.
- W2077761502 cites W2068679420 @default.
- W2077761502 cites W2073892495 @default.
- W2077761502 cites W2081912151 @default.
- W2077761502 cites W2090033907 @default.
- W2077761502 cites W2101204196 @default.
- W2077761502 cites W2103142377 @default.
- W2077761502 cites W2108060443 @default.
- W2077761502 cites W2122203983 @default.
- W2077761502 cites W2126681935 @default.
- W2077761502 cites W2143070723 @default.
- W2077761502 cites W2148299682 @default.
- W2077761502 cites W2164829352 @default.
- W2077761502 cites W2164981447 @default.
- W2077761502 cites W2166283865 @default.
- W2077761502 doi "https://doi.org/10.1074/jbc.m607063200" @default.
- W2077761502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17430898" @default.
- W2077761502 hasPublicationYear "2007" @default.
- W2077761502 type Work @default.
- W2077761502 sameAs 2077761502 @default.
- W2077761502 citedByCount "11" @default.
- W2077761502 countsByYear W20777615022012 @default.
- W2077761502 countsByYear W20777615022013 @default.
- W2077761502 countsByYear W20777615022015 @default.
- W2077761502 countsByYear W20777615022016 @default.
- W2077761502 countsByYear W20777615022020 @default.
- W2077761502 countsByYear W20777615022022 @default.
- W2077761502 crossrefType "journal-article" @default.
- W2077761502 hasAuthorship W2077761502A5024998766 @default.
- W2077761502 hasAuthorship W2077761502A5026868216 @default.
- W2077761502 hasAuthorship W2077761502A5030388070 @default.
- W2077761502 hasAuthorship W2077761502A5036314525 @default.
- W2077761502 hasAuthorship W2077761502A5049982649 @default.
- W2077761502 hasAuthorship W2077761502A5065859286 @default.
- W2077761502 hasAuthorship W2077761502A5066857412 @default.
- W2077761502 hasAuthorship W2077761502A5070000402 @default.
- W2077761502 hasAuthorship W2077761502A5077303230 @default.
- W2077761502 hasAuthorship W2077761502A5080236801 @default.
- W2077761502 hasBestOaLocation W20777615021 @default.
- W2077761502 hasConcept C104292427 @default.
- W2077761502 hasConcept C104317684 @default.
- W2077761502 hasConcept C12554922 @default.
- W2077761502 hasConcept C14053116 @default.
- W2077761502 hasConcept C167625842 @default.
- W2077761502 hasConcept C185592680 @default.
- W2077761502 hasConcept C2781338088 @default.
- W2077761502 hasConcept C515207424 @default.
- W2077761502 hasConcept C55493867 @default.
- W2077761502 hasConcept C57711820 @default.
- W2077761502 hasConcept C8010536 @default.
- W2077761502 hasConcept C86803240 @default.
- W2077761502 hasConceptScore W2077761502C104292427 @default.
- W2077761502 hasConceptScore W2077761502C104317684 @default.
- W2077761502 hasConceptScore W2077761502C12554922 @default.
- W2077761502 hasConceptScore W2077761502C14053116 @default.
- W2077761502 hasConceptScore W2077761502C167625842 @default.
- W2077761502 hasConceptScore W2077761502C185592680 @default.
- W2077761502 hasConceptScore W2077761502C2781338088 @default.
- W2077761502 hasConceptScore W2077761502C515207424 @default.
- W2077761502 hasConceptScore W2077761502C55493867 @default.
- W2077761502 hasConceptScore W2077761502C57711820 @default.
- W2077761502 hasConceptScore W2077761502C8010536 @default.
- W2077761502 hasConceptScore W2077761502C86803240 @default.
- W2077761502 hasIssue "24" @default.
- W2077761502 hasLocation W20777615021 @default.