FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077761730> ?p ?o ?g. }

• W2077761730 endingPage "e1000060" @default.
• W2077761730 startingPage "e1000060" @default.
• W2077761730 abstract "Transcription factors are central components of the intracellular regulatory networks that control gene expression. An increasingly recognized phenomenon among human transcription factors is the formation of structure upon target binding. Here, we study the folding and binding of the pKID domain of CREB to the KIX domain of the co-activator CBP. Our simulations of a topology-based Gō-type model predict a coupled folding and binding mechanism, and the existence of partially bound intermediates. From transition-path and Phi-value analyses, we find that the binding transition state resembles the unstructured state in solution, implying that CREB becomes structured only after committing to binding. A change of structure following binding is reminiscent of an induced-fit mechanism and contrasts with models in which binding occurs to pre-structured conformations that exist in the unbound state at equilibrium. Interestingly, increasing the amount of structure in the unbound pKID reduces the rate of binding, suggesting a fly-casting-like process. We find that the inclusion of attractive non-native interactions results in the formation of non-specific encounter complexes that enhance the on-rate of binding, but do not significantly change the binding mechanism. Our study helps explain how being unstructured can confer an advantage in protein target recognition. The simulations are in general agreement with the results of a recently reported nuclear magnetic resonance study, and aid in the interpretation of the experimental binding kinetics." @default.
• W2077761730 created "2016-06-24" @default.
• W2077761730 creator A5035789659 @default.
• W2077761730 creator A5038753309 @default.
• W2077761730 creator A5059620610 @default.
• W2077761730 creator A5059945365 @default.
• W2077761730 date "2008-04-11" @default.
• W2077761730 modified "2023-10-10" @default.
• W2077761730 title "Binding-Induced Folding of a Natively Unstructured Transcription Factor" @default.
• W2077761730 cites W1510940593 @default.
• W2077761730 cites W1536428180 @default.
• W2077761730 cites W1964556356 @default.
• W2077761730 cites W1965149799 @default.
• W2077761730 cites W1968910000 @default.
• W2077761730 cites W1970900907 @default.
• W2077761730 cites W1980856759 @default.
• W2077761730 cites W1983559108 @default.
• W2077761730 cites W1987415685 @default.
• W2077761730 cites W1989460472 @default.
• W2077761730 cites W1994567486 @default.
• W2077761730 cites W2000324336 @default.
• W2077761730 cites W2002050200 @default.
• W2077761730 cites W2002388054 @default.
• W2077761730 cites W2006192061 @default.
• W2077761730 cites W2006833515 @default.
• W2077761730 cites W2007016963 @default.
• W2077761730 cites W2009229814 @default.
• W2077761730 cites W2013593586 @default.
• W2077761730 cites W2015039690 @default.
• W2077761730 cites W2016170088 @default.
• W2077761730 cites W2019455970 @default.
• W2077761730 cites W2019956695 @default.
• W2077761730 cites W2021632119 @default.
• W2077761730 cites W2027578254 @default.
• W2077761730 cites W2033529039 @default.
• W2077761730 cites W2034299708 @default.
• W2077761730 cites W2034653128 @default.
• W2077761730 cites W2034718152 @default.
• W2077761730 cites W2036835637 @default.
• W2077761730 cites W2037579912 @default.
• W2077761730 cites W2038494121 @default.
• W2077761730 cites W2040078870 @default.
• W2077761730 cites W2042976701 @default.
• W2077761730 cites W2046576572 @default.
• W2077761730 cites W2052071683 @default.
• W2077761730 cites W2053960740 @default.
• W2077761730 cites W2055724834 @default.
• W2077761730 cites W2056579761 @default.
• W2077761730 cites W2056874988 @default.
• W2077761730 cites W2063810968 @default.
• W2077761730 cites W2066370108 @default.
• W2077761730 cites W2067204014 @default.
• W2077761730 cites W2067388503 @default.
• W2077761730 cites W2067704741 @default.
• W2077761730 cites W2076912135 @default.
• W2077761730 cites W2082299289 @default.
• W2077761730 cites W2082493554 @default.
• W2077761730 cites W2083164919 @default.
• W2077761730 cites W2088359631 @default.
• W2077761730 cites W2091983181 @default.
• W2077761730 cites W2097229243 @default.
• W2077761730 cites W2100365601 @default.
• W2077761730 cites W2102025585 @default.
• W2077761730 cites W2106140689 @default.
• W2077761730 cites W2112053365 @default.
• W2077761730 cites W2115273980 @default.
• W2077761730 cites W2119876135 @default.
• W2077761730 cites W2120772039 @default.
• W2077761730 cites W2145326890 @default.
• W2077761730 cites W2147466870 @default.
• W2077761730 cites W2149472608 @default.
• W2077761730 cites W2160014344 @default.
• W2077761730 cites W2160140178 @default.
• W2077761730 cites W2162166182 @default.
• W2077761730 cites W2164220403 @default.
• W2077761730 cites W2168970921 @default.
• W2077761730 cites W2169962011 @default.
• W2077761730 cites W2171546617 @default.
• W2077761730 cites W2953079104 @default.
• W2077761730 cites W49261508 @default.
• W2077761730 doi "https://doi.org/10.1371/journal.pcbi.1000060" @default.
• W2077761730 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2289845" @default.
• W2077761730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18404207" @default.
• W2077761730 hasPublicationYear "2008" @default.
• W2077761730 type Work @default.
• W2077761730 sameAs 2077761730 @default.
• W2077761730 citedByCount "194" @default.
• W2077761730 countsByYear W20777617302012 @default.
• W2077761730 countsByYear W20777617302013 @default.
• W2077761730 countsByYear W20777617302014 @default.
• W2077761730 countsByYear W20777617302015 @default.
• W2077761730 countsByYear W20777617302016 @default.
• W2077761730 countsByYear W20777617302017 @default.
• W2077761730 countsByYear W20777617302018 @default.
• W2077761730 countsByYear W20777617302019 @default.
• W2077761730 countsByYear W20777617302020 @default.
• W2077761730 countsByYear W20777617302021 @default.
• W2077761730 countsByYear W20777617302022 @default.

• next