Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077762017> ?p ?o ?g. }
- W2077762017 endingPage "9563" @default.
- W2077762017 startingPage "9554" @default.
- W2077762017 abstract "We studied the influence of the aromatic sidewalls on the ability of acyclic CB[n]-type molecular containers (1a-1e) to act as solubilizing agents for 19 insoluble drugs including the developmental anticancer agent PBS-1086. All five containers exhibit good water solubility and weak self-association (Ks ≤ 624 M(-1)). We constructed phase solubility diagrams to extract Krel and Ka values for the container·drug complexes. The acyclic CB[n]-type containers generally display significantly higher Ka values than HP-β-CD toward drugs. Containers 1a-1e bind the steroidal ring system and aromatic moieties of insoluble drugs. Compound 1b displays highest affinity toward most of the drugs studied. Containers 1a and 1b are broadly applicable and can be used to formulate a wider variety of insoluble drugs than was previously possible with cyclodextrin technology. For drugs that are solubilized by both HP-β-CD and 1a-1e, lower concentrations of 1a-1e are required to achieve identical [drug]." @default.
- W2077762017 created "2016-06-24" @default.
- W2077762017 creator A5049280385 @default.
- W2077762017 creator A5068678304 @default.
- W2077762017 date "2014-11-17" @default.
- W2077762017 modified "2023-10-01" @default.
- W2077762017 title "Acyclic Cucurbit[<i>n</i>]uril-type Molecular Containers: Influence of Aromatic Walls on their Function as Solubilizing Excipients for Insoluble Drugs" @default.
- W2077762017 cites W1966536447 @default.
- W2077762017 cites W1978713499 @default.
- W2077762017 cites W1979657535 @default.
- W2077762017 cites W1987252409 @default.
- W2077762017 cites W1988733774 @default.
- W2077762017 cites W1992434579 @default.
- W2077762017 cites W1994384674 @default.
- W2077762017 cites W1997502039 @default.
- W2077762017 cites W2006011959 @default.
- W2077762017 cites W2009071379 @default.
- W2077762017 cites W2016384435 @default.
- W2077762017 cites W2017108099 @default.
- W2077762017 cites W2020337784 @default.
- W2077762017 cites W2020451019 @default.
- W2077762017 cites W2022148362 @default.
- W2077762017 cites W2026085713 @default.
- W2077762017 cites W2026562094 @default.
- W2077762017 cites W2033560751 @default.
- W2077762017 cites W2039104539 @default.
- W2077762017 cites W2040437294 @default.
- W2077762017 cites W2044578454 @default.
- W2077762017 cites W2044594845 @default.
- W2077762017 cites W2049537163 @default.
- W2077762017 cites W2052384642 @default.
- W2077762017 cites W2053390519 @default.
- W2077762017 cites W2054125712 @default.
- W2077762017 cites W2059368453 @default.
- W2077762017 cites W2061119072 @default.
- W2077762017 cites W2067841092 @default.
- W2077762017 cites W2068017438 @default.
- W2077762017 cites W2069506489 @default.
- W2077762017 cites W2069635793 @default.
- W2077762017 cites W2074984060 @default.
- W2077762017 cites W2087571702 @default.
- W2077762017 cites W2091068412 @default.
- W2077762017 cites W2095422424 @default.
- W2077762017 cites W2099677859 @default.
- W2077762017 cites W2101479143 @default.
- W2077762017 cites W2106346416 @default.
- W2077762017 cites W2117508948 @default.
- W2077762017 cites W2120680970 @default.
- W2077762017 cites W2124905988 @default.
- W2077762017 cites W2137033022 @default.
- W2077762017 cites W2138834974 @default.
- W2077762017 cites W2139902274 @default.
- W2077762017 cites W2140711202 @default.
- W2077762017 cites W2145271930 @default.
- W2077762017 cites W2147440332 @default.
- W2077762017 cites W215025240 @default.
- W2077762017 cites W2152380893 @default.
- W2077762017 cites W2160134664 @default.
- W2077762017 cites W2161030462 @default.
- W2077762017 cites W2161159620 @default.
- W2077762017 cites W2162250373 @default.
- W2077762017 cites W2163153095 @default.
- W2077762017 cites W2164050728 @default.
- W2077762017 cites W2164227888 @default.
- W2077762017 cites W2165500943 @default.
- W2077762017 cites W2166414534 @default.
- W2077762017 cites W2169594520 @default.
- W2077762017 cites W2319967591 @default.
- W2077762017 cites W2321866038 @default.
- W2077762017 cites W2477216873 @default.
- W2077762017 cites W2809722643 @default.
- W2077762017 cites W2952528349 @default.
- W2077762017 cites W4243838097 @default.
- W2077762017 doi "https://doi.org/10.1021/jm501276u" @default.
- W2077762017 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4255735" @default.
- W2077762017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25369565" @default.
- W2077762017 hasPublicationYear "2014" @default.
- W2077762017 type Work @default.
- W2077762017 sameAs 2077762017 @default.
- W2077762017 citedByCount "90" @default.
- W2077762017 countsByYear W20777620172015 @default.
- W2077762017 countsByYear W20777620172016 @default.
- W2077762017 countsByYear W20777620172017 @default.
- W2077762017 countsByYear W20777620172018 @default.
- W2077762017 countsByYear W20777620172019 @default.
- W2077762017 countsByYear W20777620172020 @default.
- W2077762017 countsByYear W20777620172021 @default.
- W2077762017 countsByYear W20777620172022 @default.
- W2077762017 countsByYear W20777620172023 @default.
- W2077762017 crossrefType "journal-article" @default.
- W2077762017 hasAuthorship W2077762017A5049280385 @default.
- W2077762017 hasAuthorship W2077762017A5068678304 @default.
- W2077762017 hasBestOaLocation W20777620171 @default.
- W2077762017 hasConcept C155574463 @default.
- W2077762017 hasConcept C178790620 @default.
- W2077762017 hasConcept C185592680 @default.
- W2077762017 hasConcept C21951064 @default.
- W2077762017 hasConcept C2780035454 @default.