FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077763739> ?p ?o ?g. }

• W2077763739 endingPage "2184" @default.
• W2077763739 startingPage "2181" @default.
• W2077763739 abstract "The naturally occurring pyranonaphthoquinone (PNQ) antibiotic lactoquinomycin and related aglycones were found to be selective inhibitors of the serine-threonine kinase AKT. A set of synthetic PNQs were prepared and a minimum active feature set and preliminary SAR were determined. PNQ lactones inhibit the proliferation of human tumor cell lines containing constitutively activated AKT and show expected effects on cellular biomarkers. Biochemical data are presented supporting a proposed bioreductive alkylation mechanism of action." @default.
• W2077763739 created "2016-06-24" @default.
• W2077763739 creator A5004255314 @default.
• W2077763739 creator A5004822786 @default.
• W2077763739 creator A5013986449 @default.
• W2077763739 creator A5016835654 @default.
• W2077763739 creator A5023249151 @default.
• W2077763739 creator A5035064577 @default.
• W2077763739 creator A5036972722 @default.
• W2077763739 creator A5038026564 @default.
• W2077763739 creator A5039044513 @default.
• W2077763739 creator A5039791942 @default.
• W2077763739 creator A5046254779 @default.
• W2077763739 creator A5050659847 @default.
• W2077763739 creator A5052338788 @default.
• W2077763739 creator A5054371177 @default.
• W2077763739 creator A5054445318 @default.
• W2077763739 creator A5055513706 @default.
• W2077763739 creator A5057047728 @default.
• W2077763739 creator A5064669298 @default.
• W2077763739 creator A5068376674 @default.
• W2077763739 creator A5068583754 @default.
• W2077763739 date "2009-03-23" @default.
• W2077763739 modified "2023-10-16" @default.
• W2077763739 title "Pyranonaphthoquinone Lactones: A New Class of AKT Selective Kinase Inhibitors Alkylate a Regulatory Loop Cysteine" @default.
• W2077763739 cites W1487234933 @default.
• W2077763739 cites W1532275854 @default.
• W2077763739 cites W1967755361 @default.
• W2077763739 cites W1988000017 @default.
• W2077763739 cites W1991851329 @default.
• W2077763739 cites W1992517814 @default.
• W2077763739 cites W1996440567 @default.
• W2077763739 cites W201808626 @default.
• W2077763739 cites W2019047215 @default.
• W2077763739 cites W2021788152 @default.
• W2077763739 cites W2025236019 @default.
• W2077763739 cites W2029693497 @default.
• W2077763739 cites W2036854908 @default.
• W2077763739 cites W2063013228 @default.
• W2077763739 cites W2066954649 @default.
• W2077763739 cites W2081926739 @default.
• W2077763739 cites W2085691387 @default.
• W2077763739 cites W2093468577 @default.
• W2077763739 cites W2094533928 @default.
• W2077763739 cites W2151926390 @default.
• W2077763739 cites W2165210733 @default.
• W2077763739 cites W2170812185 @default.
• W2077763739 cites W2301904197 @default.
• W2077763739 cites W2317700008 @default.
• W2077763739 cites W2345674544 @default.
• W2077763739 cites W2388163742 @default.
• W2077763739 cites W2433724758 @default.
• W2077763739 cites W2950791453 @default.
• W2077763739 cites W2951518724 @default.
• W2077763739 cites W2143564669 @default.
• W2077763739 doi "https://doi.org/10.1021/jm900075g" @default.
• W2077763739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19309081" @default.
• W2077763739 hasPublicationYear "2009" @default.
• W2077763739 type Work @default.
• W2077763739 sameAs 2077763739 @default.
• W2077763739 citedByCount "59" @default.
• W2077763739 countsByYear W20777637392012 @default.
• W2077763739 countsByYear W20777637392013 @default.
• W2077763739 countsByYear W20777637392014 @default.
• W2077763739 countsByYear W20777637392015 @default.
• W2077763739 countsByYear W20777637392016 @default.
• W2077763739 countsByYear W20777637392017 @default.
• W2077763739 countsByYear W20777637392018 @default.
• W2077763739 countsByYear W20777637392019 @default.
• W2077763739 countsByYear W20777637392020 @default.
• W2077763739 countsByYear W20777637392021 @default.
• W2077763739 countsByYear W20777637392022 @default.
• W2077763739 countsByYear W20777637392023 @default.
• W2077763739 crossrefType "journal-article" @default.
• W2077763739 hasAuthorship W2077763739A5004255314 @default.
• W2077763739 hasAuthorship W2077763739A5004822786 @default.
• W2077763739 hasAuthorship W2077763739A5013986449 @default.
• W2077763739 hasAuthorship W2077763739A5016835654 @default.
• W2077763739 hasAuthorship W2077763739A5023249151 @default.
• W2077763739 hasAuthorship W2077763739A5035064577 @default.
• W2077763739 hasAuthorship W2077763739A5036972722 @default.
• W2077763739 hasAuthorship W2077763739A5038026564 @default.
• W2077763739 hasAuthorship W2077763739A5039044513 @default.
• W2077763739 hasAuthorship W2077763739A5039791942 @default.
• W2077763739 hasAuthorship W2077763739A5046254779 @default.
• W2077763739 hasAuthorship W2077763739A5050659847 @default.
• W2077763739 hasAuthorship W2077763739A5052338788 @default.
• W2077763739 hasAuthorship W2077763739A5054371177 @default.
• W2077763739 hasAuthorship W2077763739A5054445318 @default.
• W2077763739 hasAuthorship W2077763739A5055513706 @default.
• W2077763739 hasAuthorship W2077763739A5057047728 @default.
• W2077763739 hasAuthorship W2077763739A5064669298 @default.
• W2077763739 hasAuthorship W2077763739A5068376674 @default.
• W2077763739 hasAuthorship W2077763739A5068583754 @default.
• W2077763739 hasConcept C11960822 @default.
• W2077763739 hasConcept C161790260 @default.
• W2077763739 hasConcept C164361826 @default.
• W2077763739 hasConcept C181199279 @default.

• next