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- W2077764517 abstract "Poly(A), poly(I), poly(U), and a thiolated derivative poly(4-thiouridylic acid) inhibit the virion-associated transcriptase of influenza A/Victoria/75 with IDS50 values of 300, 40, 4, and 1 μg/ml, respectively. A copolymer containing 9% cytidine and 91% 4-thiouridine residues (poly(C,S4U10)) inhibits the transcriptase to the same extent as poly(4-thiouridylic acid) and the copolymer also inhibits the transcriptase from a range of A strain influenzas, B/Lee/40 and fowl plague virus. Inhibition by poly(U) is dependent on the polymeric nature of the compound: inhibition decreases with oligomers of 20 residues and less. A sugar-phosphate backbone appears to be important for inhibition since vinyl analogs of poly(U) and poly(A) have little or no inhibitory activity." @default.
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- W2077764517 date "1980-05-01" @default.
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- W2077764517 title "Inhibition of influenza virion transcriptases by polynucleotides" @default.
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- W2077764517 doi "https://doi.org/10.1016/0042-6822(80)90144-0" @default.
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