FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077767418> ?p ?o ?g. }

• W2077767418 endingPage "15" @default.
• W2077767418 startingPage "9" @default.
• W2077767418 abstract "To elucidate the antibacterial activity of Gosyuyu, the crude extract from the fruit of Evodia rutaecarpa, a Chinese herbal medicine, has been fractionated chromatographically, and each fraction was assayed for antibacterial activity against Helicobacter pylori (H. pylori) in vitro. As the result, a single spot having marked antibacterial activity against H. pylori was obtained and the chemical structure was analyzed. The isolated compound was revealed to be a novel alkyl quinolone alkaloid based on the solubility, IR spectra, NMR analysis and mass spectrometric data after purification by TLC of silica. We compared the antimicrobial activity of this compound with that of other antimicrobial agents and examined susceptibility of various intestinal pathogens. As the result, the new quinolone compounds obtained from Gosyuyu extracts were found to be a mixture of two quinolone alkaloids, 1-methyl-2-[(Z)-8-tridecenyl]-4-(1H)-quinolone and 1-methyl-2-[(Z)-7-tridecenyl]-4-(1H)-quinolone (MW: 339), reported previously. The minimum inhibitory concentration (MIC) of these compounds against reference strains and clinically isolated H. pylori strains were less than 0.05 μg/ml, which was similar to the MIC of amoxicillin and clarithromycin that are used worldwide for the eradication of H. pylori, clinically. Furthermore, it was noted that the antimicrobial activity of these compounds was highly selective against H. pylori and almost non-active against other intestinal pathogens. The above results showed that these alkyl methyl quinolone (AM quinolones) alkaloids were useful for the eradication of H. pylori without affecting other intestinal flora." @default.
• W2077767418 created "2016-06-24" @default.
• W2077767418 creator A5000201862 @default.
• W2077767418 creator A5011857907 @default.
• W2077767418 creator A5025631052 @default.
• W2077767418 creator A5040118549 @default.
• W2077767418 creator A5052515864 @default.
• W2077767418 creator A5081191749 @default.
• W2077767418 creator A5081347827 @default.
• W2077767418 creator A5090266837 @default.
• W2077767418 date "2000-01-01" @default.
• W2077767418 modified "2023-09-25" @default.
• W2077767418 title "Highly Selective Antibacterial Activity of Novel Alkyl Quinolone Alkaloids from a Chinese Herbal Medicine, Gosyuyu (Wu-Chu-Yu), against<i>Helicobacter pylori In Vitro</i>" @default.
• W2077767418 cites W1256476106 @default.
• W2077767418 cites W1956829252 @default.
• W2077767418 cites W1997314459 @default.
• W2077767418 cites W2029865847 @default.
• W2077767418 cites W2037737090 @default.
• W2077767418 cites W2084655458 @default.
• W2077767418 cites W2320937221 @default.
• W2077767418 cites W2415452617 @default.
• W2077767418 cites W2949345764 @default.
• W2077767418 doi "https://doi.org/10.1111/j.1348-0421.2000.tb01240.x" @default.
• W2077767418 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10711594" @default.
• W2077767418 hasPublicationYear "2000" @default.
• W2077767418 type Work @default.
• W2077767418 sameAs 2077767418 @default.
• W2077767418 citedByCount "84" @default.
• W2077767418 countsByYear W20777674182012 @default.
• W2077767418 countsByYear W20777674182013 @default.
• W2077767418 countsByYear W20777674182014 @default.
• W2077767418 countsByYear W20777674182015 @default.
• W2077767418 countsByYear W20777674182016 @default.
• W2077767418 countsByYear W20777674182017 @default.
• W2077767418 countsByYear W20777674182018 @default.
• W2077767418 countsByYear W20777674182019 @default.
• W2077767418 countsByYear W20777674182020 @default.
• W2077767418 countsByYear W20777674182021 @default.
• W2077767418 countsByYear W20777674182022 @default.
• W2077767418 countsByYear W20777674182023 @default.
• W2077767418 crossrefType "journal-article" @default.
• W2077767418 hasAuthorship W2077767418A5000201862 @default.
• W2077767418 hasAuthorship W2077767418A5011857907 @default.
• W2077767418 hasAuthorship W2077767418A5025631052 @default.
• W2077767418 hasAuthorship W2077767418A5040118549 @default.
• W2077767418 hasAuthorship W2077767418A5052515864 @default.
• W2077767418 hasAuthorship W2077767418A5081191749 @default.
• W2077767418 hasAuthorship W2077767418A5081347827 @default.
• W2077767418 hasAuthorship W2077767418A5090266837 @default.
• W2077767418 hasBestOaLocation W20777674181 @default.
• W2077767418 hasConcept C176947019 @default.
• W2077767418 hasConcept C185592680 @default.
• W2077767418 hasConcept C202751555 @default.
• W2077767418 hasConcept C2776409635 @default.
• W2077767418 hasConcept C2776962512 @default.
• W2077767418 hasConcept C2777667214 @default.
• W2077767418 hasConcept C2779922871 @default.
• W2077767418 hasConcept C2780104969 @default.
• W2077767418 hasConcept C4937899 @default.
• W2077767418 hasConcept C501593827 @default.
• W2077767418 hasConcept C523546767 @default.
• W2077767418 hasConcept C54355233 @default.
• W2077767418 hasConcept C55493867 @default.
• W2077767418 hasConcept C556039675 @default.
• W2077767418 hasConcept C71240020 @default.
• W2077767418 hasConcept C71924100 @default.
• W2077767418 hasConcept C86803240 @default.
• W2077767418 hasConcept C89423630 @default.
• W2077767418 hasConceptScore W2077767418C176947019 @default.
• W2077767418 hasConceptScore W2077767418C185592680 @default.
• W2077767418 hasConceptScore W2077767418C202751555 @default.
• W2077767418 hasConceptScore W2077767418C2776409635 @default.
• W2077767418 hasConceptScore W2077767418C2776962512 @default.
• W2077767418 hasConceptScore W2077767418C2777667214 @default.
• W2077767418 hasConceptScore W2077767418C2779922871 @default.
• W2077767418 hasConceptScore W2077767418C2780104969 @default.
• W2077767418 hasConceptScore W2077767418C4937899 @default.
• W2077767418 hasConceptScore W2077767418C501593827 @default.
• W2077767418 hasConceptScore W2077767418C523546767 @default.
• W2077767418 hasConceptScore W2077767418C54355233 @default.
• W2077767418 hasConceptScore W2077767418C55493867 @default.
• W2077767418 hasConceptScore W2077767418C556039675 @default.
• W2077767418 hasConceptScore W2077767418C71240020 @default.
• W2077767418 hasConceptScore W2077767418C71924100 @default.
• W2077767418 hasConceptScore W2077767418C86803240 @default.
• W2077767418 hasConceptScore W2077767418C89423630 @default.
• W2077767418 hasIssue "1" @default.
• W2077767418 hasLocation W20777674181 @default.
• W2077767418 hasLocation W20777674182 @default.
• W2077767418 hasOpenAccess W2077767418 @default.
• W2077767418 hasPrimaryLocation W20777674181 @default.
• W2077767418 hasRelatedWork W10007496 @default.
• W2077767418 hasRelatedWork W2038672409 @default.
• W2077767418 hasRelatedWork W2047791218 @default.
• W2077767418 hasRelatedWork W2100746924 @default.
• W2077767418 hasRelatedWork W2127130681 @default.
• W2077767418 hasRelatedWork W2156291973 @default.
• W2077767418 hasRelatedWork W2767202678 @default.

• next