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- W2077771475 abstract "Specific mutations associated with resistance to streptomycin (SM) inMycobacterium tuberculosissuggest themselves for its rapid prediction. However, as with any diagnostic test, their predictive values are dependent on their prevalences. In this report, SM resistance associated mutations in therrsandrpsLgenes of 25 SM resistant isolates from Germany and 25 SM resistant isolates from Sierra Leone were characterized and compared. Mutations in therrsgene were infrequent in isolates from both localities (20% and 12%, respectively) and thus of limited predictive values. In contrast,rpsLmutations were found in 48% of the German isolates but only in 24% of the isolates from Sierra Leone. It is concluded that the predictive values of mutations in this gene may vary significantly with the origin of the samples under investigation." @default.
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- W2077771475 date "1997-04-01" @default.
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- W2077771475 title "Geographic variation of the predictive values of genomic mutations associated with streptomycin resistance inMycobacterium tuberculosis" @default.
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- W2077771475 doi "https://doi.org/10.1006/mcpr.1996.0086" @default.
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