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• W2077771663 abstract "The main objective of this study was to design a suitable drug delivery system for 10-hydroxycamptothecin (HCPT). In this study, HCPT-loaded solid lipid nanoparticle (HCPT-loaded SLN) was successfully prepared. The HCPT-loaded SLN was characterized by size, entrapment efficiency and drug release manner. The cytotoxicity of HCPT-loaded SLN was assessed in vitro using HepG2/HCPT cells and in vivo utilizing human tumor xenograft nude mouse model. HCPT-loaded SLN indicated the ability to target HepG2/HCPT cells and accumulated higher drug content in HepG2/HCPT cells. HCPT-loaded SLN enhanced the cytotoxicity of HCPT in a concentration-dependent manner. Based on these results, HCPT-loaded SLN suggested being a promising vehicle for liver-targeted drug delivery. Moreover, it can be of clinical interest to overcome multidrug resistance (MDR) effectively." @default.
• W2077771663 created "2016-06-24" @default.
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• W2077771663 date "2015-03-13" @default.
• W2077771663 modified "2023-10-16" @default.
• W2077771663 title "Intracellular target delivery of 10-hydroxycamptothecin with solid lipid nanoparticles against multidrug resistance" @default.
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• W2077771663 doi "https://doi.org/10.3109/1061186x.2015.1020427" @default.
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