Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077772283> ?p ?o ?g. }
- W2077772283 endingPage "372" @default.
- W2077772283 startingPage "364" @default.
- W2077772283 abstract "Schizophrenia is highly complex multifactorial psychiatric disorder with poorly defined etiopathophysiology, which also has manifestations in the immune system.The aim of this review is to meta-analyze the available evidence regarding the role of immune activation indicated by the T helper cells in order to evaluate etiopathophysiological links between the immune system and schizophrenia.A literature search was performed in multiple electronic databases for relevant research papers published between 1990 and May 2014. Meta-analyses were conducted under both random- (REM) and fixed-effect models (FEM) by calculating weighted mean differences with 95% confidence intervals. Heterogeneity was assessed with the I(2) index.Twenty-one studies were selected after observing inclusion and exclusion criteria. In vitro interferon-gamma (INF-γ) and interleukin (IL)-2 production was significantly lower in the schizophrenic patients compared with non-schizophrenic control individuals under both FEM and REM. Serum levels of IL-2 and serum/in vitro IL-4 were not significantly different in both groups under both FEM and REM. Overall Th1:Th2 ratio (INF-γ:IL-4 and IL-2:IL-4) in the serum samples was significantly deflected towards Th2 under both models in the serum samples (- 0.33 [- 0.59 to - 0.06]; P < 0.03, FEM and - 2.44 [- 4.27 to - 0.60]; P < 0.009, REM) but in vitro production Th1:Th2 ratio (INF-γ:IL-4 and IL-2:IL-4) was deflected towards Th1 under both the models (1.11 [0.45-1.78]; P < 0.002, FEM and 6.68 [0.72-12.64]; P < 0.03, REM).Whereas the Th1:Th2 ratio in the serum samples deflected towards T2, in vitro Th1:Th2 ratio favored Th1 when the individual study data were meta-analyzed." @default.
- W2077772283 created "2016-06-24" @default.
- W2077772283 creator A5004148430 @default.
- W2077772283 creator A5014351914 @default.
- W2077772283 creator A5024014930 @default.
- W2077772283 creator A5084795769 @default.
- W2077772283 creator A5088384481 @default.
- W2077772283 date "2014-12-22" @default.
- W2077772283 modified "2023-10-16" @default.
- W2077772283 title "Role of T helper lymphokines in the immune-inflammatory pathophysiology of schizophrenia: Systematic review and meta-analysis" @default.
- W2077772283 cites W1534923950 @default.
- W2077772283 cites W1579795633 @default.
- W2077772283 cites W1946235557 @default.
- W2077772283 cites W1964579257 @default.
- W2077772283 cites W1966921418 @default.
- W2077772283 cites W1968292816 @default.
- W2077772283 cites W1970076965 @default.
- W2077772283 cites W1970450248 @default.
- W2077772283 cites W1972734373 @default.
- W2077772283 cites W1973613045 @default.
- W2077772283 cites W1986324325 @default.
- W2077772283 cites W1989580254 @default.
- W2077772283 cites W1990141657 @default.
- W2077772283 cites W2004863282 @default.
- W2077772283 cites W2007229760 @default.
- W2077772283 cites W2008873103 @default.
- W2077772283 cites W2009173247 @default.
- W2077772283 cites W2014109189 @default.
- W2077772283 cites W2015682764 @default.
- W2077772283 cites W2025056228 @default.
- W2077772283 cites W2025904789 @default.
- W2077772283 cites W2026728307 @default.
- W2077772283 cites W2027270753 @default.
- W2077772283 cites W2028726349 @default.
- W2077772283 cites W2030396834 @default.
- W2077772283 cites W2033880528 @default.
- W2077772283 cites W2035145483 @default.
- W2077772283 cites W2037762661 @default.
- W2077772283 cites W2040789766 @default.
- W2077772283 cites W2042755650 @default.
- W2077772283 cites W2045067545 @default.
- W2077772283 cites W2046442753 @default.
- W2077772283 cites W2048261054 @default.
- W2077772283 cites W2050621916 @default.
- W2077772283 cites W2056370816 @default.
- W2077772283 cites W2061585838 @default.
- W2077772283 cites W2068206691 @default.
- W2077772283 cites W2072898255 @default.
- W2077772283 cites W2076578736 @default.
- W2077772283 cites W2077087144 @default.
- W2077772283 cites W2081845379 @default.
- W2077772283 cites W2083357623 @default.
- W2077772283 cites W2086419987 @default.
- W2077772283 cites W2086549259 @default.
- W2077772283 cites W2089224748 @default.
- W2077772283 cites W2091389527 @default.
- W2077772283 cites W2092358878 @default.
- W2077772283 cites W2093506930 @default.
- W2077772283 cites W2094339928 @default.
- W2077772283 cites W2096327192 @default.
- W2077772283 cites W2109287571 @default.
- W2077772283 cites W2114767595 @default.
- W2077772283 cites W2115860248 @default.
- W2077772283 cites W2116134868 @default.
- W2077772283 cites W2124859215 @default.
- W2077772283 cites W2140164106 @default.
- W2077772283 cites W2143019449 @default.
- W2077772283 cites W2154965665 @default.
- W2077772283 cites W2155315940 @default.
- W2077772283 cites W2166909936 @default.
- W2077772283 cites W2169079754 @default.
- W2077772283 cites W2171013464 @default.
- W2077772283 cites W2172040877 @default.
- W2077772283 cites W2308559090 @default.
- W2077772283 cites W2409025718 @default.
- W2077772283 cites W2419651762 @default.
- W2077772283 doi "https://doi.org/10.3109/08039488.2014.986761" @default.
- W2077772283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25529895" @default.
- W2077772283 hasPublicationYear "2014" @default.
- W2077772283 type Work @default.
- W2077772283 sameAs 2077772283 @default.
- W2077772283 citedByCount "22" @default.
- W2077772283 countsByYear W20777722832015 @default.
- W2077772283 countsByYear W20777722832016 @default.
- W2077772283 countsByYear W20777722832017 @default.
- W2077772283 countsByYear W20777722832018 @default.
- W2077772283 countsByYear W20777722832019 @default.
- W2077772283 countsByYear W20777722832020 @default.
- W2077772283 countsByYear W20777722832021 @default.
- W2077772283 countsByYear W20777722832022 @default.
- W2077772283 countsByYear W20777722832023 @default.
- W2077772283 crossrefType "journal-article" @default.
- W2077772283 hasAuthorship W2077772283A5004148430 @default.
- W2077772283 hasAuthorship W2077772283A5014351914 @default.
- W2077772283 hasAuthorship W2077772283A5024014930 @default.
- W2077772283 hasAuthorship W2077772283A5084795769 @default.
- W2077772283 hasAuthorship W2077772283A5088384481 @default.
- W2077772283 hasConcept C10162356 @default.