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• W2077772309 startingPage "189" @default.
• W2077772309 abstract "Psychosocial stress associated with the removal of six naive juvenile rhesus monkeys from their natal social group to peer housing resulted in increased basal cortisol secretion and significant decrements in the absolute numbers of the T lymphocyte subsets in the peripheral blood. Six subjects matched for age and social rank remained in the group of 80 animals serving as controls. Baseline immune and cortisol measurements were obtained before the six test subjects were removed from the group and housed together in an outdoor circular enclosure. Blood samples were taken 24 h following removal of the test subjects from the group and at intervals thereafter through 11 weeks. Compared to controls, test subjects showed a significant decrease in the absolute numbers of CD4+ (−56.9%) and CD8+ T cells (−57.6%) and a significant increase in basal cortisol levels (+43.9%) 24 h following removal to peer housing. Group difference in the absolute numbers of most immune cells persisted through 11 weeks, whereas cortisol differences lasted only through 2 weeks. These data, when compared to an earlier study employing an identical protocol, with the exception that subjects were housed in indoor individual cages following separation, fail to demonstrate a modulating effect of randomly chosen peer-mates on the stress effects produced by social separation." @default.
• W2077772309 created "2016-06-24" @default.
• W2077772309 creator A5062089037 @default.
• W2077772309 date "1992-06-01" @default.
• W2077772309 modified "2023-09-25" @default.
• W2077772309 title "Removal from natal social group to peer housing affects cortisol levels and absolute numbers of T cell subsets in juvenile rhesus monkeys" @default.
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• W2077772309 doi "https://doi.org/10.1016/0889-1591(92)90018-j" @default.
• W2077772309 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1504371" @default.
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