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- W2077772935 abstract "This study addresses the hypothesis that exposure to peripheral arterial (ART) or coronary (COR) hemodynamics and wall biomechanics affect platelet deposition on vein segments. Intact human saphenous vein (HSV) and porcine internal jugular vein (PIJV) segments were studied under venous (VEN), ART, and COR environments using <i>in vitro</i> perfusion systems. Wall shear stress (τ) and circumferential wall stress (σ<sub>θ</sub>) were calculated for PIJV segments. Platelet deposition was measured using a radioactive assay. PIJV ART segments exhibited a 14% increase in inner diameter over time (<i>P</i> < 0.05). τ, acting on PIJV ART specimens, was less at 6 h compared with time 0 (<i>P</i> < 0.05). σ<sub>θ</sub> was lower in the VEN specimens compared with ART and COR groups (<i>P</i> < 0.01). Platelet deposition decreased by 40% on PIJV ART segments (<i>P</i> < 0.05) but increased 3.2-fold on PIJV COR segments (<i>P</i> < 0.05) <i>versus</i> VEN control segments. Platelet deposition was increased 1.75-fold in COR HSV cases <i>versus</i> VEN segments. These data indicate that short-term exposure to COR conditions lead to enhanced platelet deposition, whereas ART conditions decrease platelet deposition." @default.
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- W2077772935 date "2004-09-01" @default.
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- W2077772935 title "The influence of hemodynamics and wall biomechanics on the thrombogenicity of vein segments perfused in vitro1" @default.
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- W2077772935 doi "https://doi.org/10.1016/j.jss.2004.04.017" @default.
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