FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077773347> ?p ?o ?g. }

• W2077773347 endingPage "445" @default.
• W2077773347 startingPage "444" @default.
• W2077773347 abstract "Cyclosporine (CsA) is widely used in organ transplantation. To monitor actual drug exposure, full area under the curve (AUC) is the golden standard, but it is not feasible for routine monitoring, and several abbreviated formulas have been calculated in adults (1). We confirmed the good correlation between abbreviated and full AUC in children (2). The use of serum concentration 2 hr after CsA administration (C2) was proposed in adults undergoing heart (3), renal (4), and liver (5) transplantation. CsA metabolism demonstrates peculiarities in children: Intestinal absorption is lower, and the CsA clearance is higher (6). For these reasons, in young children, it is often necessary to administer CsA three times per day. We checked the feasibility of the C2 approach in children of different ages and with different CsA administration modalities (every 8 or 12 hr). Patients who were receiving drugs known to affect CsA metabolism were excluded from this study. A total of 43 children aged 43 to 190 months were studied. Group A consisted of nine children, aged 5 to 10 years (mean 94 months; standard deviation [SD] 17), receiving CsA twice per day, in whom 46 abbreviated AUCs were obtained. Group B consisted of 27 children, aged 11 to 15 years (mean 167 months; SD 18.5), receiving CsA twice per day, in whom 184 abbreviated AUCs were obtained. Group C consisted of seven children, aged 3 to 7 years (mean 60.1 months; SD 15.5), receiving CsA every 8 hr, in whom 68 abbreviated AUCs were obtained. The AUC in patients receiving CsA twice per day was calculated on the basis of two blood samples using the following formula: AUC=195,8+(2,4*C2)+(7,7*C6) (1). For patients in group C, the AUC was calculated on the basis of three blood samples taken just before, 1 hr, and 2 hr after the administration of the drug (2). The correlation between abbreviated AUC and C2 values and age in months was evaluated through a linear regression model in each of the groups studied and in groups A and B combined. Linear regression was also used to test the correlation between abbreviated AUC and C0, C1, and C2 in group C. The correlation between AUC and C2 in groups A, B, and C is shown in Figure 1. All linear regression models fit well, as documented by the high R2 values. Because models in groups A and B were similar, we tested a linear regression model combining all the observations of the two groups together. The correlation between AUC and C2 and age R2 was 0.84. This result shows that age does not correlate with AUC, and that C2 is sufficient to predict AUC in all age groups. Figure 1: Correlation between area under the curve (AUC) and serum concentration 2 hr after cyclosporine (CsA) administration (C2) in all groups of patients: children aged 3 to 7 years receiving CsA every 8 hr (upper); children aged 5 to 10 years receiving CsA every 12 hr (middle); patients aged 10 to 15 years receiving CsA every 12 hr (lower).The resulting equation for predicting AUC is as follows: AUC=3.75×C2+1385.25. To support these results, the correlation between AUC and C0, C1, and C2 was tested in group C. In this group of children, the best fit of the model was obtained when AUC was tested with C2. Thus, these data support the reliability of this approach in young children. L. Dello Strologo C. Pontesilli G. Rizzoni A. E. Tozzi" @default.
• W2077773347 created "2016-06-24" @default.
• W2077773347 creator A5000858931 @default.
• W2077773347 creator A5015299343 @default.
• W2077773347 creator A5015989679 @default.
• W2077773347 creator A5017755959 @default.
• W2077773347 date "2003-07-27" @default.
• W2077773347 modified "2023-10-11" @default.
• W2077773347 title "C2 monitoring: a reliable tool in pediatric renal transplant recipients" @default.
• W2077773347 cites W1561424141 @default.
• W2077773347 cites W1992886649 @default.
• W2077773347 cites W2083701329 @default.
• W2077773347 doi "https://doi.org/10.1097/01.tp.0000074312.93200.7a" @default.
• W2077773347 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12883218" @default.
• W2077773347 hasPublicationYear "2003" @default.
• W2077773347 type Work @default.
• W2077773347 sameAs 2077773347 @default.
• W2077773347 citedByCount "11" @default.
• W2077773347 countsByYear W20777733472015 @default.
• W2077773347 countsByYear W20777733472016 @default.
• W2077773347 crossrefType "journal-article" @default.
• W2077773347 hasAuthorship W2077773347A5000858931 @default.
• W2077773347 hasAuthorship W2077773347A5015299343 @default.
• W2077773347 hasAuthorship W2077773347A5015989679 @default.
• W2077773347 hasAuthorship W2077773347A5017755959 @default.
• W2077773347 hasBestOaLocation W20777733471 @default.
• W2077773347 hasConcept C112705442 @default.
• W2077773347 hasConcept C126322002 @default.
• W2077773347 hasConcept C126894567 @default.
• W2077773347 hasConcept C141071460 @default.
• W2077773347 hasConcept C187212893 @default.
• W2077773347 hasConcept C2911091166 @default.
• W2077773347 hasConcept C71924100 @default.
• W2077773347 hasConcept C76318530 @default.
• W2077773347 hasConceptScore W2077773347C112705442 @default.
• W2077773347 hasConceptScore W2077773347C126322002 @default.
• W2077773347 hasConceptScore W2077773347C126894567 @default.
• W2077773347 hasConceptScore W2077773347C141071460 @default.
• W2077773347 hasConceptScore W2077773347C187212893 @default.
• W2077773347 hasConceptScore W2077773347C2911091166 @default.
• W2077773347 hasConceptScore W2077773347C71924100 @default.
• W2077773347 hasConceptScore W2077773347C76318530 @default.
• W2077773347 hasIssue "2" @default.
• W2077773347 hasLocation W20777733471 @default.
• W2077773347 hasLocation W20777733472 @default.
• W2077773347 hasLocation W20777733473 @default.
• W2077773347 hasOpenAccess W2077773347 @default.
• W2077773347 hasPrimaryLocation W20777733471 @default.
• W2077773347 hasRelatedWork W2012213756 @default.
• W2077773347 hasRelatedWork W2097337757 @default.
• W2077773347 hasRelatedWork W2112528869 @default.
• W2077773347 hasRelatedWork W2114878163 @default.
• W2077773347 hasRelatedWork W2162888433 @default.
• W2077773347 hasRelatedWork W2352350815 @default.
• W2077773347 hasRelatedWork W2887865523 @default.
• W2077773347 hasRelatedWork W2908757458 @default.
• W2077773347 hasRelatedWork W2991030316 @default.
• W2077773347 hasRelatedWork W2189230703 @default.
• W2077773347 hasVolume "76" @default.
• W2077773347 isParatext "false" @default.
• W2077773347 isRetracted "false" @default.
• W2077773347 magId "2077773347" @default.
• W2077773347 workType "article" @default.