Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077773639> ?p ?o ?g. }
- W2077773639 abstract "Disruptions in the regulatory pathways controlling sex determination and differentiation can cause disorders of sex development, often compromising reproductive function. Although extensive efforts have been channeled into elucidating the regulatory mechanisms controlling the many aspects of sexual differentiation, the majority of disorders of sex development phenotypes are still unexplained at the molecular level. In this study, we have analyzed the potential involvement of Wnt5a in sexual development and show in mice that Wnt5a is male-specifically upregulated within testicular interstitial cells at the onset of gonad differentiation. Homozygous deletion of Wnt5a affected sexual development in male mice, causing testicular hypoplasia and bilateral cryptorchidism despite the Leydig cells producing factors such as Hsd3b1 and Insl3. Additionally, Wnt5a-null embryos of both sexes showed a significant reduction in gonadal germ cell numbers, which was caused by aberrant primordial germ cell migration along the hindgut endoderm prior to gonadal colonization. Our results indicate multiple roles for Wnt5a during mammalian reproductive development and help to clarify further the etiology of Robinow syndrome (OMIM 268310), a disease previously linked to the WNT5A pathway." @default.
- W2077773639 created "2016-06-24" @default.
- W2077773639 creator A5015541798 @default.
- W2077773639 creator A5039506361 @default.
- W2077773639 creator A5043293616 @default.
- W2077773639 creator A5045581674 @default.
- W2077773639 creator A5048173185 @default.
- W2077773639 creator A5049069814 @default.
- W2077773639 creator A5078134451 @default.
- W2077773639 creator A5083509933 @default.
- W2077773639 date "2012-01-01" @default.
- W2077773639 modified "2023-10-14" @default.
- W2077773639 title "Loss of Wnt5a Disrupts Primordial Germ Cell Migration and Male Sexual Development in Mice1" @default.
- W2077773639 cites W1485743594 @default.
- W2077773639 cites W1498970130 @default.
- W2077773639 cites W1516032812 @default.
- W2077773639 cites W1559988016 @default.
- W2077773639 cites W1566942630 @default.
- W2077773639 cites W1829371983 @default.
- W2077773639 cites W1931597824 @default.
- W2077773639 cites W1969206533 @default.
- W2077773639 cites W1969245901 @default.
- W2077773639 cites W1972966928 @default.
- W2077773639 cites W1978380475 @default.
- W2077773639 cites W1985901090 @default.
- W2077773639 cites W1988344228 @default.
- W2077773639 cites W1989027475 @default.
- W2077773639 cites W1989918771 @default.
- W2077773639 cites W1998109805 @default.
- W2077773639 cites W2000167648 @default.
- W2077773639 cites W2000334616 @default.
- W2077773639 cites W2000588521 @default.
- W2077773639 cites W2001861742 @default.
- W2077773639 cites W2002999466 @default.
- W2077773639 cites W2003608517 @default.
- W2077773639 cites W2007003847 @default.
- W2077773639 cites W2013369476 @default.
- W2077773639 cites W2030656510 @default.
- W2077773639 cites W2041850471 @default.
- W2077773639 cites W2043396979 @default.
- W2077773639 cites W2046197443 @default.
- W2077773639 cites W2049175197 @default.
- W2077773639 cites W2049540084 @default.
- W2077773639 cites W2052415794 @default.
- W2077773639 cites W2056960925 @default.
- W2077773639 cites W2058068088 @default.
- W2077773639 cites W2064988924 @default.
- W2077773639 cites W2072937904 @default.
- W2077773639 cites W2074113757 @default.
- W2077773639 cites W2078640982 @default.
- W2077773639 cites W2088190529 @default.
- W2077773639 cites W2088926937 @default.
- W2077773639 cites W2098067206 @default.
- W2077773639 cites W2098412813 @default.
- W2077773639 cites W2100004497 @default.
- W2077773639 cites W2102681710 @default.
- W2077773639 cites W2102828359 @default.
- W2077773639 cites W2105695731 @default.
- W2077773639 cites W2109971484 @default.
- W2077773639 cites W2113263838 @default.
- W2077773639 cites W2118028624 @default.
- W2077773639 cites W2118182695 @default.
- W2077773639 cites W2118705276 @default.
- W2077773639 cites W2123037811 @default.
- W2077773639 cites W2124943870 @default.
- W2077773639 cites W2130522127 @default.
- W2077773639 cites W2139211316 @default.
- W2077773639 cites W2140895840 @default.
- W2077773639 cites W2149945210 @default.
- W2077773639 cites W2151871918 @default.
- W2077773639 cites W2157259126 @default.
- W2077773639 cites W2157560047 @default.
- W2077773639 cites W2159630741 @default.
- W2077773639 cites W2160582164 @default.
- W2077773639 cites W2161492806 @default.
- W2077773639 cites W2162504561 @default.
- W2077773639 cites W2165079421 @default.
- W2077773639 cites W3020868922 @default.
- W2077773639 cites W4232225448 @default.
- W2077773639 doi "https://doi.org/10.1095/biolreprod.111.095232" @default.
- W2077773639 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21900680" @default.
- W2077773639 hasPublicationYear "2012" @default.
- W2077773639 type Work @default.
- W2077773639 sameAs 2077773639 @default.
- W2077773639 citedByCount "69" @default.
- W2077773639 countsByYear W20777736392012 @default.
- W2077773639 countsByYear W20777736392013 @default.
- W2077773639 countsByYear W20777736392014 @default.
- W2077773639 countsByYear W20777736392015 @default.
- W2077773639 countsByYear W20777736392016 @default.
- W2077773639 countsByYear W20777736392017 @default.
- W2077773639 countsByYear W20777736392018 @default.
- W2077773639 countsByYear W20777736392019 @default.
- W2077773639 countsByYear W20777736392021 @default.
- W2077773639 countsByYear W20777736392022 @default.
- W2077773639 countsByYear W20777736392023 @default.
- W2077773639 crossrefType "journal-article" @default.
- W2077773639 hasAuthorship W2077773639A5015541798 @default.
- W2077773639 hasAuthorship W2077773639A5039506361 @default.
- W2077773639 hasAuthorship W2077773639A5043293616 @default.