Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077773730> ?p ?o ?g. }
- W2077773730 endingPage "174" @default.
- W2077773730 startingPage "169" @default.
- W2077773730 abstract "Different pathways have been reported to be involved in platelet-collagen interaction. We have reported that the platelet endothelial form of nitric oxide synthase (eNOS) and the platelet receptor for type I collagen, p65, are closely associated. But the controlling mechanism underlying the generation of nitric oxide (NO) by the eNOS has not been fully explored. In this investigation, Western blot analyses of time course samples with anti-phosphorylated tyrosine, and anti-serine/threonine showed a marked increase in serine/threonine phosphorylation of eNOS during type I collagen-induced platelet aggregation. Meanwhile, the eNOS activity measured by the conversion of [3H]-arginine to [3H]-citrulline is significantly decreased. Correlation of type I collagen-induced platelet aggregation and the activity of eNOS in the presence of the serine/threonine phosphatase inhibitor, okadiac acid and the tyrosine phosphatase inhibitor, vanadate were performed with PRP. Results show the decrease in eNOS activity by adding okadiac acid correlated with the inhibitory effect on platelet aggregation in a dose-dependent manner. On the other hand, vanadate significantly inhibits platelet aggregation and also inhibits eNOS activity when the concentration of vanadate is greater than 2 mM. These results suggest that phosphorylation of serine/threonine and tyrosine residues control the activity of eNOS through different mechanisms to affect collagen-induced platelet aggregation." @default.
- W2077773730 created "2016-06-24" @default.
- W2077773730 creator A5037176537 @default.
- W2077773730 creator A5085928314 @default.
- W2077773730 creator A5091517816 @default.
- W2077773730 date "2002-10-01" @default.
- W2077773730 modified "2023-10-11" @default.
- W2077773730 title "Role of platelet endothelial form of nitric oxide synthase in collagen–platelet interaction: regulation by phosphorylation" @default.
- W2077773730 cites W1481953740 @default.
- W2077773730 cites W1491490245 @default.
- W2077773730 cites W1607892649 @default.
- W2077773730 cites W1934180097 @default.
- W2077773730 cites W1970078269 @default.
- W2077773730 cites W1986437440 @default.
- W2077773730 cites W1991364029 @default.
- W2077773730 cites W1993859463 @default.
- W2077773730 cites W1999597903 @default.
- W2077773730 cites W2005007281 @default.
- W2077773730 cites W2006079873 @default.
- W2077773730 cites W2012214760 @default.
- W2077773730 cites W2018122321 @default.
- W2077773730 cites W2020269025 @default.
- W2077773730 cites W2021156311 @default.
- W2077773730 cites W2024978467 @default.
- W2077773730 cites W2028746948 @default.
- W2077773730 cites W2037452092 @default.
- W2077773730 cites W2037876524 @default.
- W2077773730 cites W2038307719 @default.
- W2077773730 cites W2038510313 @default.
- W2077773730 cites W2040721011 @default.
- W2077773730 cites W2045079760 @default.
- W2077773730 cites W2059379142 @default.
- W2077773730 cites W2066518001 @default.
- W2077773730 cites W2067057392 @default.
- W2077773730 cites W2068820862 @default.
- W2077773730 cites W2084168776 @default.
- W2077773730 cites W2092794968 @default.
- W2077773730 cites W2100837269 @default.
- W2077773730 cites W2125786682 @default.
- W2077773730 cites W2128619290 @default.
- W2077773730 cites W2132440861 @default.
- W2077773730 cites W2135297555 @default.
- W2077773730 cites W2137718997 @default.
- W2077773730 cites W2224266189 @default.
- W2077773730 doi "https://doi.org/10.1016/s0167-4889(02)00311-7" @default.
- W2077773730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12379480" @default.
- W2077773730 hasPublicationYear "2002" @default.
- W2077773730 type Work @default.
- W2077773730 sameAs 2077773730 @default.
- W2077773730 citedByCount "17" @default.
- W2077773730 countsByYear W20777737302014 @default.
- W2077773730 countsByYear W20777737302015 @default.
- W2077773730 crossrefType "journal-article" @default.
- W2077773730 hasAuthorship W2077773730A5037176537 @default.
- W2077773730 hasAuthorship W2077773730A5085928314 @default.
- W2077773730 hasAuthorship W2077773730A5091517816 @default.
- W2077773730 hasConcept C11960822 @default.
- W2077773730 hasConcept C126322002 @default.
- W2077773730 hasConcept C134018914 @default.
- W2077773730 hasConcept C178790620 @default.
- W2077773730 hasConcept C185592680 @default.
- W2077773730 hasConcept C2775880066 @default.
- W2077773730 hasConcept C2776165026 @default.
- W2077773730 hasConcept C2776414213 @default.
- W2077773730 hasConcept C2777553839 @default.
- W2077773730 hasConcept C2777622882 @default.
- W2077773730 hasConcept C2778326061 @default.
- W2077773730 hasConcept C2781116636 @default.
- W2077773730 hasConcept C2908688039 @default.
- W2077773730 hasConcept C519581460 @default.
- W2077773730 hasConcept C55493867 @default.
- W2077773730 hasConcept C71924100 @default.
- W2077773730 hasConcept C86803240 @default.
- W2077773730 hasConcept C89560881 @default.
- W2077773730 hasConceptScore W2077773730C11960822 @default.
- W2077773730 hasConceptScore W2077773730C126322002 @default.
- W2077773730 hasConceptScore W2077773730C134018914 @default.
- W2077773730 hasConceptScore W2077773730C178790620 @default.
- W2077773730 hasConceptScore W2077773730C185592680 @default.
- W2077773730 hasConceptScore W2077773730C2775880066 @default.
- W2077773730 hasConceptScore W2077773730C2776165026 @default.
- W2077773730 hasConceptScore W2077773730C2776414213 @default.
- W2077773730 hasConceptScore W2077773730C2777553839 @default.
- W2077773730 hasConceptScore W2077773730C2777622882 @default.
- W2077773730 hasConceptScore W2077773730C2778326061 @default.
- W2077773730 hasConceptScore W2077773730C2781116636 @default.
- W2077773730 hasConceptScore W2077773730C2908688039 @default.
- W2077773730 hasConceptScore W2077773730C519581460 @default.
- W2077773730 hasConceptScore W2077773730C55493867 @default.
- W2077773730 hasConceptScore W2077773730C71924100 @default.
- W2077773730 hasConceptScore W2077773730C86803240 @default.
- W2077773730 hasConceptScore W2077773730C89560881 @default.
- W2077773730 hasIssue "2" @default.
- W2077773730 hasLocation W20777737301 @default.
- W2077773730 hasLocation W20777737302 @default.
- W2077773730 hasOpenAccess W2077773730 @default.
- W2077773730 hasPrimaryLocation W20777737301 @default.
- W2077773730 hasRelatedWork W102080802 @default.