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• W2077774449 abstract "A synthon of D-proline substituted at the 4-position by thymine and at N by a flexible aminoethyl linker, has been used to prepare a novel chiral peptide nucleic acid (cPNA) with (2R,4R) stereochemistry using solid phase methodology. The homothymine decamer cPNA binds to complementary polyadenylic acid to form a 2:1 hybrid with high affinity and specificity according to UV and CD studies, whereas no binding to the corresponding polydeoxyadenylic acid was observed." @default.
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• W2077774449 date "2000-11-01" @default.
• W2077774449 modified "2023-10-16" @default.
• W2077774449 title "Synthesis and properties of chiral peptide nucleic acids with a N-Aminoethyl-d-proline backbone" @default.
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• W2077774449 doi "https://doi.org/10.1016/s0960-894x(00)00507-2" @default.
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