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• W2077774675 abstract "Summary Interleukin‐12 (IL‐12) has been shown to enhance cellular immunity in vitro and in vivo . The beneficial roles of IL‐12 as a DNA vaccine adjuvant have been commonly observed. Here the impact of IL‐12 complementary DNA (cDNA) as an adjuvant for a human papillomavirus (HPV) type 16 E7 DNA vaccine is investigated in a mouse tumour model. Coinjection of E7 DNA vaccine with IL‐12 cDNA completely suppressed antigen‐specific cytotoxic T‐lymphocyte (CTL) responses, leading to a complete loss of antitumour protection from a tumour cell challenge. In addition, antigen‐specific antibody and T helper cell proliferative responses were also suppressed by IL‐12 cDNA coinjection. This inhibition was observed over different IL‐12 cDNA doses. Furthermore, separate leg injections of IL‐12 and E7 cDNAs suppressed antigen‐specific CTL and tumour protective responses, but not antibody and T helper cell proliferative responses, suggesting different pathways for suppression of these two separate responses. Further knockout animal studies demonstrated that interferon‐γ and nitric oxide are not directly associated with suppression of antigen‐specific antibody responses by IL‐12 cDNA coinjection. However, nitric oxide was found to be involved in suppression of antigen‐specific CTL and tumour protective responses by IL‐12 cDNA coinjection. These data suggest that coinjection of IL‐12 cDNA results in suppression of E7‐specific CTL responses through nitric oxide, leading to a loss of antitumour resistance in this DNA vaccine model. This study further shows that the adjuvant effect of IL‐12 is dependent on the antigen types tested." @default.
• W2077774675 created "2016-06-24" @default.
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• W2077774675 date "2009-08-04" @default.
• W2077774675 modified "2023-10-16" @default.
• W2077774675 title "Suppression of antitumour protective cytotoxic T lymphocyte responses to a human papillomavirus 16 E7 DNA vaccine by coinjection of interleukin-12 complementary DNA: involvement of nitric oxide in immune suppression" @default.
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• W2077774675 doi "https://doi.org/10.1111/j.1365-2567.2009.03068.x" @default.
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