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• W2077776628 abstract "Although suspected to exist as a pancreatic hyperglycemic factor as early as 1923, isolated and crystallized by 1953, and measurable by radioimmunoassay since 1959, only in the last decade has glucagon become firmly established as a critical hormone in the minute-to-minute regulation of the blood glucose concentration. This aspect of glucagon physiology has been discussed in detail elsewhere in this volume. The purpose of the present chapter is to review a second area of fuel homeostasis in which the A-cell hormone has again emerged as a central regulatory factor, namely, the control of hepatic fatty acid metabolism and ketone body production. From an historical standpoint, the function of glucagon in this area gained recognition even more recently than its role in the regulation of glucose metabolism, most of the significant advances having been made only in the last 15 years or so. Not surprisingly, a number of interesting parallelisms between the two systems have begun to evolve. Thus, it now appears that the same bihormonal mechanism (reciprocal changes in the levels of insulin and glucagon), instrumental in permitting the liver to respond smoothly to periods of food deprivation with accelerated release of glucose, also induces production of ketone bodies to support the energy needs of the brain and peripheral tissues. By the same token, severe imbalance between the two hormones, such as occurs in uncontrolled diabetes, is now recognized as a primary factor in the etiology of the two major metabolic derangements associated with this disorder, namely, hyperglycemia and ketoacidosis." @default.
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• W2077776628 date "1976-11-01" @default.
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• W2077776628 title "Glucagon and ketogenesis" @default.
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• W2077776628 doi "https://doi.org/10.1016/s0026-0495(76)80148-5" @default.
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