Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077776865> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2077776865 abstract "Introduction Today there is a large number of antidepressant drugs. However, the effect of treatment is often suboptimal. Unlike other antidepressants agomelatine has a novel neurochemical mechanism. It is an MT1 and MT2 melatonergic receptor agonist and a selective antagonist of the 5-HT2C receptors. In this open-label 8-week study we aimed to investigate the efficacy of agomelatine on depressive symptoms in patients with major depression. Secondary endpoints were the effect of agomelatine on anhedonia. Methods Thirty major depressive patients received a flexible dose (25–50 mg; per os, daily) of agomelatine. Depressive (Hamilton Depression Scale) and anxious (Hamilton Anxiety Scale) symptoms, anhedonia (Snaith Hamilton Rating Scale), and sleep quality (Leeds Sleep Evaluation Questionnaire) were assessed. Results Twenty-four patients (80%) completed 8 weeks of treatment. Significant improvements were seen at all visits on the HAM-D (p< .05), HAM-A(p< .01), SHAPS (p< .05), LSEQ (p< .05). Nine subjects (30%) were responders and 5 (17%) remitters at week 1; 18 (60%) were remitters by the end of the trial. There was no serious adverse event. No aminotrasferase elevations were noted. Discussion In line with previous studies, in which agomelatine was associated with early clinical improvement this study also provides evidence of an early response and the findings of improvements in depression scores. Beside this is the first study where agomelatine was effective in the treatment of anhedonia. Additional trials are needed to delineate the place of agomelatine in the contemporary pharmacotherapy for depressive disorders." @default.
- W2077776865 created "2016-06-24" @default.
- W2077776865 creator A5029208007 @default.
- W2077776865 creator A5062268890 @default.
- W2077776865 creator A5070312407 @default.
- W2077776865 creator A5079243546 @default.
- W2077776865 creator A5085949775 @default.
- W2077776865 creator A5088980579 @default.
- W2077776865 date "2011-03-01" @default.
- W2077776865 modified "2023-09-23" @default.
- W2077776865 title "Major depressive disorder, anhedonia, and agomelatine: An open-label study" @default.
- W2077776865 doi "https://doi.org/10.1016/s0924-9338(11)72356-2" @default.
- W2077776865 hasPublicationYear "2011" @default.
- W2077776865 type Work @default.
- W2077776865 sameAs 2077776865 @default.
- W2077776865 citedByCount "3" @default.
- W2077776865 countsByYear W20777768652019 @default.
- W2077776865 countsByYear W20777768652023 @default.
- W2077776865 crossrefType "journal-article" @default.
- W2077776865 hasAuthorship W2077776865A5029208007 @default.
- W2077776865 hasAuthorship W2077776865A5062268890 @default.
- W2077776865 hasAuthorship W2077776865A5070312407 @default.
- W2077776865 hasAuthorship W2077776865A5079243546 @default.
- W2077776865 hasAuthorship W2077776865A5085949775 @default.
- W2077776865 hasAuthorship W2077776865A5088980579 @default.
- W2077776865 hasConcept C118552586 @default.
- W2077776865 hasConcept C126322002 @default.
- W2077776865 hasConcept C139719470 @default.
- W2077776865 hasConcept C15744967 @default.
- W2077776865 hasConcept C162324750 @default.
- W2077776865 hasConcept C2776867660 @default.
- W2077776865 hasConcept C2778941446 @default.
- W2077776865 hasConcept C2779177272 @default.
- W2077776865 hasConcept C2780051608 @default.
- W2077776865 hasConcept C2780733359 @default.
- W2077776865 hasConcept C2780798758 @default.
- W2077776865 hasConcept C513476851 @default.
- W2077776865 hasConcept C558461103 @default.
- W2077776865 hasConcept C71924100 @default.
- W2077776865 hasConceptScore W2077776865C118552586 @default.
- W2077776865 hasConceptScore W2077776865C126322002 @default.
- W2077776865 hasConceptScore W2077776865C139719470 @default.
- W2077776865 hasConceptScore W2077776865C15744967 @default.
- W2077776865 hasConceptScore W2077776865C162324750 @default.
- W2077776865 hasConceptScore W2077776865C2776867660 @default.
- W2077776865 hasConceptScore W2077776865C2778941446 @default.
- W2077776865 hasConceptScore W2077776865C2779177272 @default.
- W2077776865 hasConceptScore W2077776865C2780051608 @default.
- W2077776865 hasConceptScore W2077776865C2780733359 @default.
- W2077776865 hasConceptScore W2077776865C2780798758 @default.
- W2077776865 hasConceptScore W2077776865C513476851 @default.
- W2077776865 hasConceptScore W2077776865C558461103 @default.
- W2077776865 hasConceptScore W2077776865C71924100 @default.
- W2077776865 hasLocation W20777768651 @default.
- W2077776865 hasOpenAccess W2077776865 @default.
- W2077776865 hasPrimaryLocation W20777768651 @default.
- W2077776865 hasRelatedWork W116480265 @default.
- W2077776865 hasRelatedWork W1558149471 @default.
- W2077776865 hasRelatedWork W1981852180 @default.
- W2077776865 hasRelatedWork W1984657720 @default.
- W2077776865 hasRelatedWork W1991367613 @default.
- W2077776865 hasRelatedWork W2023091818 @default.
- W2077776865 hasRelatedWork W2052733954 @default.
- W2077776865 hasRelatedWork W2056356983 @default.
- W2077776865 hasRelatedWork W2065459613 @default.
- W2077776865 hasRelatedWork W2117602042 @default.
- W2077776865 hasRelatedWork W2141979672 @default.
- W2077776865 hasRelatedWork W2308742096 @default.
- W2077776865 hasRelatedWork W2373276872 @default.
- W2077776865 hasRelatedWork W2384540084 @default.
- W2077776865 hasRelatedWork W2468100861 @default.
- W2077776865 hasRelatedWork W2545381381 @default.
- W2077776865 hasRelatedWork W2552515050 @default.
- W2077776865 hasRelatedWork W2951309985 @default.
- W2077776865 hasRelatedWork W3129382822 @default.
- W2077776865 hasRelatedWork W2911129655 @default.
- W2077776865 isParatext "false" @default.
- W2077776865 isRetracted "false" @default.
- W2077776865 magId "2077776865" @default.
- W2077776865 workType "article" @default.