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- W2077778637 abstract "The contest between the host factor APOBEC3G (A3G) and the HIV-1 protein Vif presents an attractive target of intervention. The extent to which the A3G-Vif interaction must be suppressed to tilt the balance in favor of A3G remains unknown. We employed stochastic simulations and mathematical modeling of the within-host dynamics and evolution of HIV-1 to estimate the fraction of progeny virions that must incorporate A3G to render productive infection unsustainable. Using three different approaches, we found consistently that a transition from sustained infection to suppression of productive infection occurred when the latter fraction exceeded ~0.8. The transition was triggered by A3G-induced hypermutations that led to premature stop codons compromising viral production and was consistent with driving the basic reproductive number, R0, below unity. The fraction identified may serve as a quantitative guideline for strategies targeting the A3G-Vif axis." @default.
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- W2077778637 date "2014-01-01" @default.
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- W2077778637 title "Estimating the fraction of progeny virions that must incorporate APOBEC3G for suppression of productive HIV-1 infection" @default.
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- W2077778637 doi "https://doi.org/10.1016/j.virol.2013.11.026" @default.
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