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- W2077779913 abstract "The 11β-steroid hydroxylation and oxidative phosphorylation were examined in mitochondria isolated from adrenal glands surgically removed from 4 patients with Cushing's disease. With the substrates used (isocitrate, malate, and β-OH-butyrate), steroid hydroxylation was blocked by KCN but could be restored by ATP, indicating an energy requirement. Only a partial inhibition due to KCN was observed with isocitrate and malate and, in agreement with this, latent forms of both malic enzyme and the NADP-linked isocitrate dehydrogenase were present in the mitochondria. The latter enzyme had the higher specific activity. The conversion of 11-deoxycortisol to cortisol was about 2 times faster than the hydroxylation of deoxycorticosterone to corticosterone. Oxidative phosphorylation supported by several substrates was examined with the oxygen electrode. High ADP/O and respiratory control ratios and ADPstimulated respiratory rates were observed. (Endocrinology 88: 318, 1971)" @default.
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- W2077779913 date "1971-02-01" @default.
- W2077779913 modified "2023-09-27" @default.
- W2077779913 title "Steroid Hydroxylation and Oxidative Phosphorylation in Human Adrenal Cortex Mitochondria" @default.
- W2077779913 doi "https://doi.org/10.1210/endo-88-2-318" @default.
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