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• W2077797625 endingPage "93" @default.
• W2077797625 startingPage "83" @default.
• W2077797625 abstract "Several mixed ligand vanadium and copper complexes were synthesized containing 8-hydroxyquinoline (8HQ) and a ligand such as picolinato (pic(-)), dipicolinato (dipic(2-)) or a Schiff base. The complexes were characterized by spectroscopic techniques and by single-crystal X-ray diffraction in the case of [V(V)O(L-pheolnaph-im)(5-Cl-8HQ)] and [V(V)O(OMe)(8HQ)2], which evidenced the distorted octahedral geometry of the complexes. The electronic absorption data showed the presence of strong ligand to metal charge transfer bands, significant solvent effects, and methoxido species in methanol, which was further confirmed by (51)V-NMR spectroscopy. The structures of [Cu(II)(dipic)(8HQ)]Na and [V(IV)O(pic)(8HQ)] were confirmed by EPR spectroscopy, showing only one species in solution. The biological activity of the compounds was assessed through the minimal inhibitory concentration (MIC) of the compounds against Mycobacterium tuberculosis (Mtb) and the cytotoxic activity against the cisplatin sensitive/resistant ovarian cells A2780/A2780cisR and the non-tumorigenic HEK cells (IC50 values). Almost all tested vanadium complexes were very active against Mtb and the MICs were comparable to, or better than, the MICs of drugs, such as streptomycin. The activity of the complexes against the A2780 cell line was dependent on incubation time presenting IC50 values in the 3-14 μM (at 48 h) range. In these conditions, the complexes were significantly (*P<0.05-**P<0.001) more active than cisplatin (22 μM), in the A2780 cells and even surpassing its activity in the cisplatin-resistant cells A2780cisR (2.4-8 μM vs. 75.4; **P<0.001). In the non-tumorigenic HEK cells poor selectivity toward cancer cells for most of the complexes was observed, as well as for cisplatin." @default.
• W2077797625 created "2016-06-24" @default.
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• W2077797625 date "2014-12-01" @default.
• W2077797625 modified "2023-10-16" @default.
• W2077797625 title "Hydroxyquinoline derived vanadium(IV and V) and copper(II) complexes as potential anti-tuberculosis and anti-tumor agents" @default.
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• W2077797625 cites W1973519721 @default.
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• W2077797625 cites W1980384439 @default.
• W2077797625 cites W1981323635 @default.
• W2077797625 cites W1983649305 @default.
• W2077797625 cites W1986002075 @default.
• W2077797625 cites W1991453949 @default.
• W2077797625 cites W2002092381 @default.
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• W2077797625 cites W2027562820 @default.
• W2077797625 cites W2028880520 @default.
• W2077797625 cites W2030119105 @default.
• W2077797625 cites W2039431696 @default.
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• W2077797625 cites W2044642838 @default.
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• W2077797625 cites W2049438963 @default.
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• W2077797625 cites W2057935211 @default.
• W2077797625 cites W2061115990 @default.
• W2077797625 cites W2062700295 @default.
• W2077797625 cites W2063039714 @default.
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• W2077797625 cites W2072754176 @default.
• W2077797625 cites W2079322422 @default.
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• W2077797625 cites W2086882548 @default.
• W2077797625 cites W2087333756 @default.
• W2077797625 cites W2094150952 @default.
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• W2077797625 cites W2112190513 @default.
• W2077797625 cites W2115544494 @default.
• W2077797625 cites W2116128143 @default.
• W2077797625 cites W2122125971 @default.
• W2077797625 cites W2126576359 @default.
• W2077797625 cites W2133138130 @default.
• W2077797625 cites W2133324295 @default.
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• W2077797625 cites W2134443949 @default.
• W2077797625 cites W2135258142 @default.
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• W2077797625 cites W2138882047 @default.
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• W2077797625 cites W2313995040 @default.
• W2077797625 cites W34816746 @default.
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• W2077797625 doi "https://doi.org/10.1016/j.jinorgbio.2014.07.019" @default.
• W2077797625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25226436" @default.
• W2077797625 hasPublicationYear "2014" @default.
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