Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077799930> ?p ?o ?g. }
- W2077799930 endingPage "1463" @default.
- W2077799930 startingPage "1451" @default.
- W2077799930 abstract "This paper presents an overview of the potential of chitosan-based systems for improving the retention and biodistribution of drugs applied topically onto the eye. Besides its low toxicity and good ocular tolerance, chitosan exhibits favourable biological behaviour, such as bioadhesion- and permeability-enhancing properties, and also interesting physico-chemical characteristics, which make it a unique material for the design of ocular drug delivery vehicles. The review summarizes the techniques for the production of chitosan gels, chitosan-coated colloidal systems and chitosan nanoparticles, and describes their mechanism of action upon contact with the ocular mucosa. The results reported until now have provided evidence of the potential of chitosan gels for enhancing and prolonging the retention of drugs on the eye surface. On the other hand, chitosan-based colloidal systems were found to work as transmucosal drug carriers, either facilitating the transport of drugs to the inner eye (chitosan-coated colloidal systems containing indometacin) or their accumulation into the corneal/conjunctival epithelia (chitosan nanoparticles containing ciclosporin). Finally, the tolerance, toxicity and biodegradation of the carriers under evaluation were reviewed." @default.
- W2077799930 created "2016-06-24" @default.
- W2077799930 creator A5020799070 @default.
- W2077799930 creator A5031298057 @default.
- W2077799930 date "2003-11-01" @default.
- W2077799930 modified "2023-10-10" @default.
- W2077799930 title "The potential of chitosan in ocular drug delivery" @default.
- W2077799930 cites W107354208 @default.
- W2077799930 cites W1238203966 @default.
- W2077799930 cites W1498725963 @default.
- W2077799930 cites W1541781779 @default.
- W2077799930 cites W1568216484 @default.
- W2077799930 cites W160189274 @default.
- W2077799930 cites W195513463 @default.
- W2077799930 cites W1965733855 @default.
- W2077799930 cites W1971209096 @default.
- W2077799930 cites W1972583535 @default.
- W2077799930 cites W1973901893 @default.
- W2077799930 cites W1976418823 @default.
- W2077799930 cites W1978199644 @default.
- W2077799930 cites W1980004507 @default.
- W2077799930 cites W1980296334 @default.
- W2077799930 cites W1986180285 @default.
- W2077799930 cites W1987017096 @default.
- W2077799930 cites W1994156686 @default.
- W2077799930 cites W1995207112 @default.
- W2077799930 cites W1997398888 @default.
- W2077799930 cites W1998975741 @default.
- W2077799930 cites W2003026662 @default.
- W2077799930 cites W2003038786 @default.
- W2077799930 cites W2004216555 @default.
- W2077799930 cites W2004539400 @default.
- W2077799930 cites W2005173893 @default.
- W2077799930 cites W2007067975 @default.
- W2077799930 cites W2013168158 @default.
- W2077799930 cites W2013998409 @default.
- W2077799930 cites W2015943769 @default.
- W2077799930 cites W2027481207 @default.
- W2077799930 cites W2038984754 @default.
- W2077799930 cites W2041485284 @default.
- W2077799930 cites W2043502318 @default.
- W2077799930 cites W2047601930 @default.
- W2077799930 cites W2051842899 @default.
- W2077799930 cites W2053944183 @default.
- W2077799930 cites W2056970592 @default.
- W2077799930 cites W2063276424 @default.
- W2077799930 cites W2066854206 @default.
- W2077799930 cites W2068159204 @default.
- W2077799930 cites W2070533510 @default.
- W2077799930 cites W2072515072 @default.
- W2077799930 cites W2077053064 @default.
- W2077799930 cites W2077917891 @default.
- W2077799930 cites W2084710923 @default.
- W2077799930 cites W2085318976 @default.
- W2077799930 cites W2086586009 @default.
- W2077799930 cites W2089494336 @default.
- W2077799930 cites W2106169256 @default.
- W2077799930 cites W2106839778 @default.
- W2077799930 cites W2110373623 @default.
- W2077799930 cites W2117176525 @default.
- W2077799930 cites W2125352668 @default.
- W2077799930 cites W2146129300 @default.
- W2077799930 cites W2153320168 @default.
- W2077799930 cites W2156112012 @default.
- W2077799930 cites W2156311649 @default.
- W2077799930 cites W2161656515 @default.
- W2077799930 cites W2165137027 @default.
- W2077799930 cites W86975699 @default.
- W2077799930 cites W95996289 @default.
- W2077799930 doi "https://doi.org/10.1211/0022357022476" @default.
- W2077799930 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14713355" @default.
- W2077799930 hasPublicationYear "2003" @default.
- W2077799930 type Work @default.
- W2077799930 sameAs 2077799930 @default.
- W2077799930 citedByCount "296" @default.
- W2077799930 countsByYear W20777999302012 @default.
- W2077799930 countsByYear W20777999302013 @default.
- W2077799930 countsByYear W20777999302014 @default.
- W2077799930 countsByYear W20777999302015 @default.
- W2077799930 countsByYear W20777999302016 @default.
- W2077799930 countsByYear W20777999302017 @default.
- W2077799930 countsByYear W20777999302018 @default.
- W2077799930 countsByYear W20777999302019 @default.
- W2077799930 countsByYear W20777999302020 @default.
- W2077799930 countsByYear W20777999302021 @default.
- W2077799930 countsByYear W20777999302022 @default.
- W2077799930 countsByYear W20777999302023 @default.
- W2077799930 crossrefType "journal-article" @default.
- W2077799930 hasAuthorship W2077799930A5020799070 @default.
- W2077799930 hasAuthorship W2077799930A5031298057 @default.
- W2077799930 hasBestOaLocation W20777999301 @default.
- W2077799930 hasConcept C13245373 @default.
- W2077799930 hasConcept C171250308 @default.
- W2077799930 hasConcept C185592680 @default.
- W2077799930 hasConcept C192562407 @default.
- W2077799930 hasConcept C2779732960 @default.
- W2077799930 hasConcept C2779820397 @default.
- W2077799930 hasConcept C2780020223 @default.