Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077800215> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2077800215 endingPage "1299" @default.
- W2077800215 startingPage "1283" @default.
- W2077800215 abstract "Camptothecin (CPT) is an anti-cancer drug with low solubility in aqueous solutions, which limits its efficacy during chemotherapy. To bypass this problem, CPT was conjugated to poly(ethylene glycol) (PEG) to make CPT more hydrophilic: CM-PEG-CPT (carboxylmethylpoly(ethlyene glycol)-camptothecin), CM-PEG-GLY-CPT (carboxylmethyl-poly(ethlyene glycol)-glycine-camptothecin) and CM-PEG-SAR-CPT (carboxylmethyl-poly(ethlyene glycol)-sarcosine camptothecin) were synthesized. These conjugates differed in the amino-acid linker, which altered the hydrolysis rate of CPT from CPT-PEG. We tested the hypothesis that CPT conjugates were more effective than unconjugated CPT in effectiveness upon direct delivery to solid tumors using two systems: in vitro tumor spheroids suspended in collagen gels and in vivo solid tumors in rats. CPT was effective in spheroids, but not in flank tumors. However, when CPT was conjugated, there was improvement in the treatment of spheroids and, to a lesser extent, tumors in rats. There was no difference in therapeutic effects among the various conjugates. We conclude that conjugation of CPT to PEG enhances CPT solubility and improves effectiveness of delivery to tumors." @default.
- W2077800215 created "2016-06-24" @default.
- W2077800215 creator A5019632853 @default.
- W2077800215 creator A5052296033 @default.
- W2077800215 creator A5074752640 @default.
- W2077800215 creator A5089454973 @default.
- W2077800215 date "2007-01-01" @default.
- W2077800215 modified "2023-10-02" @default.
- W2077800215 title "Efficacy of camptothecin and polymer-conjugated camptothecin in tumor spheroids and solid tumors" @default.
- W2077800215 cites W1977620790 @default.
- W2077800215 cites W2005482676 @default.
- W2077800215 cites W2006337478 @default.
- W2077800215 cites W2052795767 @default.
- W2077800215 cites W2054184538 @default.
- W2077800215 cites W205461530 @default.
- W2077800215 cites W2073676974 @default.
- W2077800215 doi "https://doi.org/10.1163/156856207782177918" @default.
- W2077800215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17939886" @default.
- W2077800215 hasPublicationYear "2007" @default.
- W2077800215 type Work @default.
- W2077800215 sameAs 2077800215 @default.
- W2077800215 citedByCount "11" @default.
- W2077800215 countsByYear W20778002152012 @default.
- W2077800215 countsByYear W20778002152013 @default.
- W2077800215 countsByYear W20778002152016 @default.
- W2077800215 countsByYear W20778002152017 @default.
- W2077800215 countsByYear W20778002152021 @default.
- W2077800215 countsByYear W20778002152023 @default.
- W2077800215 crossrefType "journal-article" @default.
- W2077800215 hasAuthorship W2077800215A5019632853 @default.
- W2077800215 hasAuthorship W2077800215A5052296033 @default.
- W2077800215 hasAuthorship W2077800215A5074752640 @default.
- W2077800215 hasAuthorship W2077800215A5089454973 @default.
- W2077800215 hasConcept C10138342 @default.
- W2077800215 hasConcept C111919701 @default.
- W2077800215 hasConcept C112613896 @default.
- W2077800215 hasConcept C12554922 @default.
- W2077800215 hasConcept C134306372 @default.
- W2077800215 hasConcept C150903083 @default.
- W2077800215 hasConcept C162324750 @default.
- W2077800215 hasConcept C178790620 @default.
- W2077800215 hasConcept C185592680 @default.
- W2077800215 hasConcept C197336794 @default.
- W2077800215 hasConcept C207001950 @default.
- W2077800215 hasConcept C2777516009 @default.
- W2077800215 hasConcept C2779682216 @default.
- W2077800215 hasConcept C2779820397 @default.
- W2077800215 hasConcept C2780557392 @default.
- W2077800215 hasConcept C33923547 @default.
- W2077800215 hasConcept C41008148 @default.
- W2077800215 hasConcept C521977710 @default.
- W2077800215 hasConcept C54400483 @default.
- W2077800215 hasConcept C55493867 @default.
- W2077800215 hasConcept C86803240 @default.
- W2077800215 hasConcept C98274493 @default.
- W2077800215 hasConceptScore W2077800215C10138342 @default.
- W2077800215 hasConceptScore W2077800215C111919701 @default.
- W2077800215 hasConceptScore W2077800215C112613896 @default.
- W2077800215 hasConceptScore W2077800215C12554922 @default.
- W2077800215 hasConceptScore W2077800215C134306372 @default.
- W2077800215 hasConceptScore W2077800215C150903083 @default.
- W2077800215 hasConceptScore W2077800215C162324750 @default.
- W2077800215 hasConceptScore W2077800215C178790620 @default.
- W2077800215 hasConceptScore W2077800215C185592680 @default.
- W2077800215 hasConceptScore W2077800215C197336794 @default.
- W2077800215 hasConceptScore W2077800215C207001950 @default.
- W2077800215 hasConceptScore W2077800215C2777516009 @default.
- W2077800215 hasConceptScore W2077800215C2779682216 @default.
- W2077800215 hasConceptScore W2077800215C2779820397 @default.
- W2077800215 hasConceptScore W2077800215C2780557392 @default.
- W2077800215 hasConceptScore W2077800215C33923547 @default.
- W2077800215 hasConceptScore W2077800215C41008148 @default.
- W2077800215 hasConceptScore W2077800215C521977710 @default.
- W2077800215 hasConceptScore W2077800215C54400483 @default.
- W2077800215 hasConceptScore W2077800215C55493867 @default.
- W2077800215 hasConceptScore W2077800215C86803240 @default.
- W2077800215 hasConceptScore W2077800215C98274493 @default.
- W2077800215 hasIssue "10" @default.
- W2077800215 hasLocation W20778002151 @default.
- W2077800215 hasLocation W20778002152 @default.
- W2077800215 hasOpenAccess W2077800215 @default.
- W2077800215 hasPrimaryLocation W20778002151 @default.
- W2077800215 hasRelatedWork W1982267003 @default.
- W2077800215 hasRelatedWork W1990414540 @default.
- W2077800215 hasRelatedWork W1996860722 @default.
- W2077800215 hasRelatedWork W2000375983 @default.
- W2077800215 hasRelatedWork W2022426542 @default.
- W2077800215 hasRelatedWork W2069791068 @default.
- W2077800215 hasRelatedWork W2092580324 @default.
- W2077800215 hasRelatedWork W2555163562 @default.
- W2077800215 hasRelatedWork W2795407923 @default.
- W2077800215 hasRelatedWork W4361282636 @default.
- W2077800215 hasVolume "18" @default.
- W2077800215 isParatext "false" @default.
- W2077800215 isRetracted "false" @default.
- W2077800215 magId "2077800215" @default.
- W2077800215 workType "article" @default.