FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077807487> ?p ?o ?g. }

• W2077807487 abstract "During prolonged ischemic cardiac arrest successful myocardial protection depends upon uniform delivery of cardioplegic solutions to all regions of the heart. Accordingly, we studied the regional and transmural distribution of a neutral crystalloid (dextran-saline) solution during normothermic (37 degrees C) ischemia in 18 isolated blood-perfused dog hearts (isovolumic left ventricle). In the baseline state, coronary perfusion pressure was 100 mmHg. At the onset of ischemia and every 15 min throughout ischemia, we infused 100 ml of crystalloid solution (37 degrees C) at a perfusion pressure of 100 mmHg and the distribution of crystalloid solution was assessed (radioactive microsphere technique). The hearts were reperfused after 60 min (n = 9) or 90 mins (n = 9) of ischemia. In the baseline pre-arrest state the left ventricle (LV) received 67 +/- 1.0% of the total coronary blood flow; the LV subendocardial to subepicardial flow ratio was 1.33 +/- 0.18, the LV end diastolic pressure was 7.5 +/- 0.4 mmHg, and mean transmural myocardial adenosine triphosphate (ATP) was 16.4 +/- 1.1 microM/g DW. At the onset and throughout the first 45 mins of ischemia (n = 9), regional and transmural distribution of the crystalloid solution was similar to that of coronary blood flow during the baseline state; there was no change in LV end diastolic pressure, but there was a moderate fall in ATP content (7.26 +/- 1.6 micron/g DW). After 75 mins of ischemia (n = 9), despite the development of ischemic contracture (LV end diastolic pressure exceeded 20 mmHg in all 9 hearts) and marked ATP depletion (2.76 +/- 0.5 microM/g DW), there was an increase in crystalloid solution delivery to the LV as a whole and the subendocardium in particular (the LV received 82 +/- 2.0% and the subendocardial to subepicardial flow ratio was 1.75 +/- 0.1). Even in a subgroup with severe contracture during ischemic arrest (LV end diastolic pressure greater than 60 mmHg, n = 4) there was no reduction in crystalloid solution delivery. Thus, the presence of ischemic contracture does not preclude delivery of crystalloid solution to the LV subendocardium." @default.
• W2077807487 created "2016-06-24" @default.
• W2077807487 creator A5021809803 @default.
• W2077807487 creator A5047833899 @default.
• W2077807487 creator A5051847688 @default.
• W2077807487 creator A5061160552 @default.
• W2077807487 creator A5064996486 @default.
• W2077807487 creator A5081073925 @default.
• W2077807487 creator A5090004654 @default.
• W2077807487 date "1987-10-01" @default.
• W2077807487 modified "2023-09-27" @default.
• W2077807487 title "Distribution of a neutral cardioplegic vehicle during the development of ischemic myocardial contracture**" @default.
• W2077807487 cites W1976061817 @default.
• W2077807487 cites W1977517077 @default.
• W2077807487 cites W1979576695 @default.
• W2077807487 cites W1985764401 @default.
• W2077807487 cites W2007348055 @default.
• W2077807487 cites W2013509807 @default.
• W2077807487 cites W2021253052 @default.
• W2077807487 cites W2033943371 @default.
• W2077807487 cites W2041158130 @default.
• W2077807487 cites W2044881190 @default.
• W2077807487 cites W2045055126 @default.
• W2077807487 cites W2047359177 @default.
• W2077807487 cites W2050552736 @default.
• W2077807487 cites W2057057697 @default.
• W2077807487 cites W2065201394 @default.
• W2077807487 cites W2067204054 @default.
• W2077807487 cites W2073054261 @default.
• W2077807487 cites W2086293321 @default.
• W2077807487 cites W2110213928 @default.
• W2077807487 cites W2115654053 @default.
• W2077807487 cites W2122689055 @default.
• W2077807487 cites W2131170703 @default.
• W2077807487 cites W2140233303 @default.
• W2077807487 cites W2227507121 @default.
• W2077807487 cites W2261916154 @default.
• W2077807487 cites W2274582051 @default.
• W2077807487 cites W2394882619 @default.
• W2077807487 cites W2403383049 @default.
• W2077807487 cites W2404264562 @default.
• W2077807487 cites W2411003541 @default.
• W2077807487 cites W2414213698 @default.
• W2077807487 cites W2415026881 @default.
• W2077807487 cites W2415998322 @default.
• W2077807487 cites W2416825706 @default.
• W2077807487 cites W2417676910 @default.
• W2077807487 cites W2418480804 @default.
• W2077807487 cites W2419169897 @default.
• W2077807487 cites W2434412803 @default.
• W2077807487 cites W2439794640 @default.
• W2077807487 cites W2440079827 @default.
• W2077807487 cites W3135029803 @default.
• W2077807487 cites W43460244 @default.
• W2077807487 doi "https://doi.org/10.1016/s0022-2828(87)80570-9" @default.
• W2077807487 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2449532" @default.
• W2077807487 hasPublicationYear "1987" @default.
• W2077807487 type Work @default.
• W2077807487 sameAs 2077807487 @default.
• W2077807487 citedByCount "6" @default.
• W2077807487 crossrefType "journal-article" @default.
• W2077807487 hasAuthorship W2077807487A5021809803 @default.
• W2077807487 hasAuthorship W2077807487A5047833899 @default.
• W2077807487 hasAuthorship W2077807487A5051847688 @default.
• W2077807487 hasAuthorship W2077807487A5061160552 @default.
• W2077807487 hasAuthorship W2077807487A5064996486 @default.
• W2077807487 hasAuthorship W2077807487A5081073925 @default.
• W2077807487 hasAuthorship W2077807487A5090004654 @default.
• W2077807487 hasConcept C126322002 @default.
• W2077807487 hasConcept C146957229 @default.
• W2077807487 hasConcept C158846371 @default.
• W2077807487 hasConcept C164705383 @default.
• W2077807487 hasConcept C178853913 @default.
• W2077807487 hasConcept C26635844 @default.
• W2077807487 hasConcept C2777055891 @default.
• W2077807487 hasConcept C2777397205 @default.
• W2077807487 hasConcept C2777862461 @default.
• W2077807487 hasConcept C2778165595 @default.
• W2077807487 hasConcept C2778921608 @default.
• W2077807487 hasConcept C42219234 @default.
• W2077807487 hasConcept C48277249 @default.
• W2077807487 hasConcept C541997718 @default.
• W2077807487 hasConcept C57900726 @default.
• W2077807487 hasConcept C71924100 @default.
• W2077807487 hasConcept C84393581 @default.
• W2077807487 hasConceptScore W2077807487C126322002 @default.
• W2077807487 hasConceptScore W2077807487C146957229 @default.
• W2077807487 hasConceptScore W2077807487C158846371 @default.
• W2077807487 hasConceptScore W2077807487C164705383 @default.
• W2077807487 hasConceptScore W2077807487C178853913 @default.
• W2077807487 hasConceptScore W2077807487C26635844 @default.
• W2077807487 hasConceptScore W2077807487C2777055891 @default.
• W2077807487 hasConceptScore W2077807487C2777397205 @default.
• W2077807487 hasConceptScore W2077807487C2777862461 @default.
• W2077807487 hasConceptScore W2077807487C2778165595 @default.
• W2077807487 hasConceptScore W2077807487C2778921608 @default.
• W2077807487 hasConceptScore W2077807487C42219234 @default.
• W2077807487 hasConceptScore W2077807487C48277249 @default.
• W2077807487 hasConceptScore W2077807487C541997718 @default.
• W2077807487 hasConceptScore W2077807487C57900726 @default.

• next