Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077807745> ?p ?o ?g. }
- W2077807745 endingPage "784" @default.
- W2077807745 startingPage "775" @default.
- W2077807745 abstract "Use of synthetic peptides as vaccine components is hampered by their susceptibility to enzymatic degradation and rapid clearance from biological fluids. Introduction of non-natural structural modifications can render peptides more resistant to enzymatic degradation, encouraging attempts to profile such non-natural ligands as components of synthetic sub-unit vaccines. We have compared the antigenic and immunogenic properties of a series of non-natural peptide analogues derived from a promiscuous T cell epitope of the major Plasmodium falciparum malaria vaccine candidate merozoite surface protein 1 (MSP-1). A series of HLA class II restricted MSP-1(38-58)-specific TCC established from three volunteers were characterized for their minimal epitope and fine specificity. T cell stimulatory activities of a series of pseudo-peptide analogues with single reduced peptide bond Psi-[CH2-NH] modifications were compared with those of single d-amino acid replacement analogues. Compared to reduced peptide bond analogues the single d-amino acid replacement analogues turned out to be less suitable for stimulation of TCC. In particular, the reduced peptide analogue carrying a Psi-[CH2-NH] backbone modification between positions V52 and L53 of MSP-1(38-58) demonstrated properties that would make it a more suitable vaccine component than the unmodified parent peptide. First, the pseudo-peptide stimulated a number of TCC restricted by a range of HLA class II alleles. Second, trypsin treatment in combination with T cell stimulation assays provided evidence for increased resistance to proteolytic digestion. Third, the parasite-binding anti-MSP-1 mAb 7.27 recognized best this particular pseudo-peptide in competition ELISA experiments and its immunogenicity in out-bred Aotus monkeys was superior to that of the parent peptide eliciting antibodies cross-reactive with native MSP-1." @default.
- W2077807745 created "2016-06-24" @default.
- W2077807745 creator A5026314935 @default.
- W2077807745 creator A5037230655 @default.
- W2077807745 creator A5067280335 @default.
- W2077807745 creator A5067379459 @default.
- W2077807745 creator A5080742149 @default.
- W2077807745 date "2004-07-01" @default.
- W2077807745 modified "2023-10-14" @default.
- W2077807745 title "Characterization of a reduced peptide bond analogue of a promiscuous CD4 T cell epitope derived from the Plasmodium falciparum malaria vaccine candidate merozoite surface protein 1" @default.
- W2077807745 cites W138284649 @default.
- W2077807745 cites W1417879642 @default.
- W2077807745 cites W1595220827 @default.
- W2077807745 cites W1807410736 @default.
- W2077807745 cites W1879969470 @default.
- W2077807745 cites W1962127316 @default.
- W2077807745 cites W1963587733 @default.
- W2077807745 cites W1978999256 @default.
- W2077807745 cites W1988621079 @default.
- W2077807745 cites W1993632294 @default.
- W2077807745 cites W2006217355 @default.
- W2077807745 cites W2006410415 @default.
- W2077807745 cites W2009881302 @default.
- W2077807745 cites W2010228869 @default.
- W2077807745 cites W2014904488 @default.
- W2077807745 cites W2018027982 @default.
- W2077807745 cites W2018969381 @default.
- W2077807745 cites W2027561555 @default.
- W2077807745 cites W2029718898 @default.
- W2077807745 cites W2041763155 @default.
- W2077807745 cites W2046265343 @default.
- W2077807745 cites W2062806060 @default.
- W2077807745 cites W2065262834 @default.
- W2077807745 cites W2068746444 @default.
- W2077807745 cites W2068759264 @default.
- W2077807745 cites W2071358919 @default.
- W2077807745 cites W2074034504 @default.
- W2077807745 cites W2082265331 @default.
- W2077807745 cites W2082762936 @default.
- W2077807745 cites W2097352048 @default.
- W2077807745 cites W2110901597 @default.
- W2077807745 cites W2113595465 @default.
- W2077807745 cites W2119229070 @default.
- W2077807745 cites W2120997299 @default.
- W2077807745 cites W2127745456 @default.
- W2077807745 cites W2137321433 @default.
- W2077807745 cites W2150756957 @default.
- W2077807745 cites W2162657387 @default.
- W2077807745 cites W2165224041 @default.
- W2077807745 cites W2405591407 @default.
- W2077807745 cites W2473477431 @default.
- W2077807745 cites W2550622704 @default.
- W2077807745 doi "https://doi.org/10.1016/j.molimm.2004.04.019" @default.
- W2077807745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15234557" @default.
- W2077807745 hasPublicationYear "2004" @default.
- W2077807745 type Work @default.
- W2077807745 sameAs 2077807745 @default.
- W2077807745 citedByCount "12" @default.
- W2077807745 countsByYear W20778077452017 @default.
- W2077807745 countsByYear W20778077452019 @default.
- W2077807745 countsByYear W20778077452021 @default.
- W2077807745 countsByYear W20778077452023 @default.
- W2077807745 crossrefType "journal-article" @default.
- W2077807745 hasAuthorship W2077807745A5026314935 @default.
- W2077807745 hasAuthorship W2077807745A5037230655 @default.
- W2077807745 hasAuthorship W2077807745A5067280335 @default.
- W2077807745 hasAuthorship W2077807745A5067379459 @default.
- W2077807745 hasAuthorship W2077807745A5080742149 @default.
- W2077807745 hasConcept C104317684 @default.
- W2077807745 hasConcept C147483822 @default.
- W2077807745 hasConcept C153911025 @default.
- W2077807745 hasConcept C159047783 @default.
- W2077807745 hasConcept C167625842 @default.
- W2077807745 hasConcept C185592680 @default.
- W2077807745 hasConcept C195616568 @default.
- W2077807745 hasConcept C203014093 @default.
- W2077807745 hasConcept C2776789287 @default.
- W2077807745 hasConcept C2778048844 @default.
- W2077807745 hasConcept C2778371730 @default.
- W2077807745 hasConcept C2779281246 @default.
- W2077807745 hasConcept C2781034427 @default.
- W2077807745 hasConcept C31684184 @default.
- W2077807745 hasConcept C515207424 @default.
- W2077807745 hasConcept C55493867 @default.
- W2077807745 hasConcept C86803240 @default.
- W2077807745 hasConceptScore W2077807745C104317684 @default.
- W2077807745 hasConceptScore W2077807745C147483822 @default.
- W2077807745 hasConceptScore W2077807745C153911025 @default.
- W2077807745 hasConceptScore W2077807745C159047783 @default.
- W2077807745 hasConceptScore W2077807745C167625842 @default.
- W2077807745 hasConceptScore W2077807745C185592680 @default.
- W2077807745 hasConceptScore W2077807745C195616568 @default.
- W2077807745 hasConceptScore W2077807745C203014093 @default.
- W2077807745 hasConceptScore W2077807745C2776789287 @default.
- W2077807745 hasConceptScore W2077807745C2778048844 @default.
- W2077807745 hasConceptScore W2077807745C2778371730 @default.
- W2077807745 hasConceptScore W2077807745C2779281246 @default.
- W2077807745 hasConceptScore W2077807745C2781034427 @default.