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• W2077810682 startingPage "20120826" @default.
• W2077810682 abstract "The pattern of gene expression in a developing tissue determines the spatial organization of cell type generation. We previously defined regulatory interactions between a set of transcription factors that specify the pattern of gene expression in progenitors of different neuronal subtypes of the vertebrate neural tube. These transcription factors form a circuit that acts as a multistate switch, patterning the tissue in response to a gradient of Sonic Hedgehog. Here, by simplifying aspects of the regulatory interactions, we found that the topology of the circuit allows either switch-like or oscillatory behaviour depending on parameter values. The qualitative dynamics appear to be controlled by a simpler sub-circuit, which we term the AC–DC motif. We argue that its topology provides a natural way to implement a multistate gene expression switch and we show that the circuit is readily extendable to produce more distinct stripes of gene expression. Our analysis also suggests that AC–DC motifs could be deployed in tissues patterned by oscillatory mechanisms, thus blurring the distinction between pattern-formation mechanisms relying on temporal oscillations or graded signals. Furthermore, during evolution, mechanisms of gradient interpretation might have arisen from oscillatory circuits, or vice versa." @default.
• W2077810682 created "2016-06-24" @default.
• W2077810682 creator A5013121079 @default.
• W2077810682 creator A5019391436 @default.
• W2077810682 creator A5042672436 @default.
• W2077810682 date "2013-02-06" @default.
• W2077810682 modified "2023-10-14" @default.
• W2077810682 title "A gene regulatory motif that generates oscillatory or multiway switch outputs" @default.
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• W2077810682 doi "https://doi.org/10.1098/rsif.2012.0826" @default.
• W2077810682 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3565701" @default.
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