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• W2077811722 abstract "Since antiquity, medical herbs have been prescribed for both treatment and preventative purposes. Herbal formulas are used to reduce toxicity as well as increase efficacy in traditional Korean medicine. U-bang-haequi tang (UBT) is a herbal prescription containing Arctii fructus and Forsythia suspensa as its main components and has treated many human diseases in traditional Korean medicine. This research investigated the effects of UBT against an acute phase of inflammation. For this, we measured induction of nitric oxide (NO) and related proteins in macrophage cell line stimulated by lipopolysaccharide (LPS). Further, paw swelling was measured in carrageenan-treated rats. Carrageenan significantly induced activation of inflammatory cells and increases in paw volume, whereas oral administration of 0.3 or 1 g/kg/day of UBT inhibited the acute inflammatory response. In RAW264.7 cells, UBT inhibited mRNA and protein expression levels of iNOS. UBT treatment also blocked elevation of NO production, nuclear translocation of NF-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:mi>κ</mml:mi></mml:mrow></mml:math>B, phosphorylation of I<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mrow><mml:mi>κ</mml:mi></mml:mrow></mml:math>-B<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mrow><mml:mi>α</mml:mi></mml:mrow></mml:math>induced by LPS. Moreover, UBT treatment significantly blocked the phosphorylation of p38 and c-Jun NH2-terminal kinases by LPS. In conclusion, UBT prevented both acute inflammation in rats as well as LPS-induced NO and iNOS gene expression through inhibition of NF-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mrow><mml:mi>κ</mml:mi></mml:mrow></mml:math>B in RAW264.7 cells." @default.
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• W2077811722 date "2014-01-01" @default.
• W2077811722 modified "2023-09-25" @default.
• W2077811722 title "<i>U-Bang-Haequi Tang</i>: A Herbal Prescription that Prevents Acute Inflammation through Inhibition of NF-<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mi mathvariant=bold-italic>κ</mml:mi></mml:mrow></mml:math>B-Mediated Inducible Nitric Oxide Synthase" @default.
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• W2077811722 doi "https://doi.org/10.1155/2014/542825" @default.
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