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- W2077812341 abstract "Cervical cancer is a complex and multifactorial disease. Although there are substantial data supporting the causative role of persistent human papillomavirus (HPV) infection in the development of cervical cancer, the complete course of the disease has never been completely understood. Several risk cofactors have been suggested with controversial results. Portugal has the highest incidence of squamous cell carcinoma (SCC) within western Europe and there are no known studies regarding the role of cofactors in SCC. The aim of our study was to evaluate the role of smoking, sexual behaviour, reproductive and contraceptive history, in the time-to-onset (TTO) of severe cervical lesions (HGSIL/SCC) in the Portuguese population. We verified that age of first sexual intercourse under 18 years (odds ratio (OR) 2.8), pregnancy (OR 2.9), first pregnancy under 21 years (2.6), number of pregnancies (OR 2.3–5.4) and parity (OR 1.9–5.7) are risk factors in the development of cervical neoplasia. Smoke exposure index (SEI) was significantly different (P=0.002) between cases and controls. Our results regarding time-to-onset demonstrate that smoking (P<0.001, log rank test), number of sexual partners (P<0.001, log rank test) and use of oral contraceptives (P<0.001, log rank test) are important determinants in the earlier onset of severe cervical lesions. Using this approach, our findings may help to clarify the role of smoking and other cofactors in the persistence and progression of cervical lesions." @default.
- W2077812341 created "2016-06-24" @default.
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- W2077812341 date "2005-10-01" @default.
- W2077812341 modified "2023-10-18" @default.
- W2077812341 title "The influence of smoking and other cofactors on the time to onset to cervical cancer in a southern European population" @default.
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- W2077812341 cites W1643155728 @default.
- W2077812341 cites W1846490331 @default.
- W2077812341 cites W1881144545 @default.
- W2077812341 cites W1952568400 @default.
- W2077812341 cites W1952594819 @default.
- W2077812341 cites W1966886063 @default.
- W2077812341 cites W1972857320 @default.
- W2077812341 cites W1972996919 @default.
- W2077812341 cites W1978576085 @default.
- W2077812341 cites W1981592676 @default.
- W2077812341 cites W1987350137 @default.
- W2077812341 cites W1989913063 @default.
- W2077812341 cites W1992659165 @default.
- W2077812341 cites W1994873916 @default.
- W2077812341 cites W1996872538 @default.
- W2077812341 cites W1997600127 @default.
- W2077812341 cites W2001400232 @default.
- W2077812341 cites W2003683078 @default.
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- W2077812341 cites W2005811844 @default.
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- W2077812341 cites W2022986385 @default.
- W2077812341 cites W2024793014 @default.
- W2077812341 cites W2024981819 @default.
- W2077812341 cites W2033699718 @default.
- W2077812341 cites W2039569210 @default.
- W2077812341 cites W2040402526 @default.
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- W2077812341 cites W2100321400 @default.
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- W2077812341 cites W2287979283 @default.
- W2077812341 cites W2313576254 @default.
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- W2077812341 doi "https://doi.org/10.1097/01.cej.0000174780.44260.32" @default.
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