FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077820682> ?p ?o ?g. }

• W2077820682 endingPage "261" @default.
• W2077820682 startingPage "251" @default.
• W2077820682 abstract "The study was aimed to investigate the protective effects of rosuvastatin on spinal cord ischemia in rats and to determine the effects of this agent on the expressions of nitric oxide synthase (NOS). Spinal cord ischemia was induced in male Sprague-Dawley rats by occluding the descending thoracic aorta. Experimental groups (n=30 per group) were as follows: sham operation, control (receiving only normal saline), rosuvastatin (5 mg/kg/day for 10 days before occlusion), and rosuvastatin-mevalonate (5 mg/kg/day rosuvastatin and 5 mg/kg/day mevalonate for 10 days before occlusion). Neurological function was assessed at 6, 12, 24, 48, and 72 h after reperfusion. After 72 h reperfusion, spinal cords were harvested for 2,3,5,-triphenyltetrazolium chloride (TTC) staining, TUNEL staining, and nitric oxide (NO) assay. Immunohistochemistry, reverse transcription polymerase chain reaction and western blot were performed to determine the expressions of inducible, endothelial, and neuronal NOS (iNOS, eNOS, and nNOS) in rats with spinal cord ischemia. Spinal cord ischemia thus induced was marked by neurological dysfunction, spinal infarction, and neural cell apoptosis in animals. The results show that rosuvastatin significantly reduced the motor disturbance and the volume of infarctions and attenuated apoptotic neural cells death in the treated rats. Treatment with rosuvastatin remarkably decreased the NO level in spinal cord tissue. In addition, rosuvastatin inhibited iNOS mRNA and protein expression and increased eNOS mRNA and protein expression. However, rosuvastatin had no influence on nNOS mRNA and protein expression. Administrations of mevalonate completely reversed the changes caused by rosuvastatin. These results indicate that rosuvastatin can protect rat spinal cord against ischemia injury by modulation of NOS expressions." @default.
• W2077820682 created "2016-06-24" @default.
• W2077820682 creator A5022245711 @default.
• W2077820682 creator A5025665194 @default.
• W2077820682 creator A5042323521 @default.
• W2077820682 creator A5087272086 @default.
• W2077820682 creator A5087869110 @default.
• W2077820682 date "2010-07-01" @default.
• W2077820682 modified "2023-09-23" @default.
• W2077820682 title "Rosuvastatin preconditioning provides neuroprotection against spinal cord ischemia in rats through modulating nitric oxide synthase expressions" @default.
• W2077820682 cites W1545266136 @default.
• W2077820682 cites W1564372937 @default.
• W2077820682 cites W1667686291 @default.
• W2077820682 cites W1965418020 @default.
• W2077820682 cites W1975941571 @default.
• W2077820682 cites W1990669417 @default.
• W2077820682 cites W1994333676 @default.
• W2077820682 cites W1994976436 @default.
• W2077820682 cites W2001615105 @default.
• W2077820682 cites W2003012156 @default.
• W2077820682 cites W2017885661 @default.
• W2077820682 cites W2024556319 @default.
• W2077820682 cites W2028942026 @default.
• W2077820682 cites W2029020003 @default.
• W2077820682 cites W2033275453 @default.
• W2077820682 cites W2033511358 @default.
• W2077820682 cites W2037183104 @default.
• W2077820682 cites W2040618052 @default.
• W2077820682 cites W2040797118 @default.
• W2077820682 cites W2043294394 @default.
• W2077820682 cites W2047362612 @default.
• W2077820682 cites W2051876980 @default.
• W2077820682 cites W2063738580 @default.
• W2077820682 cites W2070749438 @default.
• W2077820682 cites W2071124826 @default.
• W2077820682 cites W2071248867 @default.
• W2077820682 cites W2074187719 @default.
• W2077820682 cites W2075777731 @default.
• W2077820682 cites W2076731990 @default.
• W2077820682 cites W2087664582 @default.
• W2077820682 cites W2089896252 @default.
• W2077820682 cites W2096015727 @default.
• W2077820682 cites W2098683031 @default.
• W2077820682 cites W2107952841 @default.
• W2077820682 cites W2108116605 @default.
• W2077820682 cites W2110106971 @default.
• W2077820682 cites W2126937110 @default.
• W2077820682 cites W2132895844 @default.
• W2077820682 cites W2135826176 @default.
• W2077820682 cites W2140936548 @default.
• W2077820682 cites W2146615847 @default.
• W2077820682 cites W2148071155 @default.
• W2077820682 cites W2162779892 @default.
• W2077820682 cites W2170645579 @default.
• W2077820682 cites W2290538778 @default.
• W2077820682 cites W41406262 @default.
• W2077820682 doi "https://doi.org/10.1016/j.brainres.2010.05.068" @default.
• W2077820682 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20513366" @default.
• W2077820682 hasPublicationYear "2010" @default.
• W2077820682 type Work @default.
• W2077820682 sameAs 2077820682 @default.
• W2077820682 citedByCount "32" @default.
• W2077820682 countsByYear W20778206822012 @default.
• W2077820682 countsByYear W20778206822013 @default.
• W2077820682 countsByYear W20778206822014 @default.
• W2077820682 countsByYear W20778206822015 @default.
• W2077820682 countsByYear W20778206822016 @default.
• W2077820682 countsByYear W20778206822017 @default.
• W2077820682 countsByYear W20778206822018 @default.
• W2077820682 countsByYear W20778206822020 @default.
• W2077820682 countsByYear W20778206822021 @default.
• W2077820682 countsByYear W20778206822022 @default.
• W2077820682 crossrefType "journal-article" @default.
• W2077820682 hasAuthorship W2077820682A5022245711 @default.
• W2077820682 hasAuthorship W2077820682A5025665194 @default.
• W2077820682 hasAuthorship W2077820682A5042323521 @default.
• W2077820682 hasAuthorship W2077820682A5087272086 @default.
• W2077820682 hasAuthorship W2077820682A5087869110 @default.
• W2077820682 hasConcept C118552586 @default.
• W2077820682 hasConcept C126322002 @default.
• W2077820682 hasConcept C134018914 @default.
• W2077820682 hasConcept C196795494 @default.
• W2077820682 hasConcept C204232928 @default.
• W2077820682 hasConcept C25498285 @default.
• W2077820682 hasConcept C2777622882 @default.
• W2077820682 hasConcept C2778326061 @default.
• W2077820682 hasConcept C2780114680 @default.
• W2077820682 hasConcept C2780499067 @default.
• W2077820682 hasConcept C2780775167 @default.
• W2077820682 hasConcept C42219234 @default.
• W2077820682 hasConcept C519581460 @default.
• W2077820682 hasConcept C541997718 @default.
• W2077820682 hasConcept C71924100 @default.
• W2077820682 hasConcept C98274493 @default.
• W2077820682 hasConceptScore W2077820682C118552586 @default.
• W2077820682 hasConceptScore W2077820682C126322002 @default.
• W2077820682 hasConceptScore W2077820682C134018914 @default.
• W2077820682 hasConceptScore W2077820682C196795494 @default.

• next