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- W2077821351 abstract "Neuroprotective properties of bromocriptine, a D2 receptor agonist, were investigated using the in vitro neurotoxicity of levodopa for dopaminergic neurons from rat embryonic ventral mesencephalon. Levodopa, when added to the culture medium, showed toxicity which was specific for dopaminergic neurons. Bromocriptine was found to protect dopaminergic neurons from levodopa toxicity. Another D2 agonist, 2-(N-phenethyl-N-propyl-amino-5-hydroxytetralin, showed similar protective effects. The neuroprotective effect of bromocriptine was inhibited by supplementation of the culture medium with sulpiride, a D2 antagonist, or by D2 receptor knockdown with an antisense oligonucleotide. Dopaminergic neurons treated with levodopa showed an increase in free radicals. These data suggest that neuroprotective properties of bromocriptine seen in this cellular model of neurotoxicity are dependent on dopamine D2 autoreceptor binding and that levodopa toxicity may be related to increased free radical generation in dopaminergic neurons." @default.
- W2077821351 created "2016-06-24" @default.
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- W2077821351 date "1999-09-01" @default.
- W2077821351 modified "2023-10-15" @default.
- W2077821351 title "Bromocriptine Protects Dopaminergic Neurons from Levodopa-Induced Toxicity by Stimulating D2Receptors" @default.
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- W2077821351 doi "https://doi.org/10.1006/exnr.1999.7122" @default.
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