FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077826743> ?p ?o ?g. }

• W2077826743 endingPage "896" @default.
• W2077826743 startingPage "892" @default.
• W2077826743 abstract "Background: Oral glycerol reduces severe neurologic sequelae in childhood bacterial meningitis, but the mechanism awaits elucidation. We conducted a prospective, randomized, double-blind study in which the effects of glycerol and intravenous dexamethasone were compared with placebo recipients in an intensive care setting in India. Methods: Thirty-six children at age 2 months to 12 years with meningitis were treated with ceftriaxone and were randomized to receive also either dexamethasone intravenously, or glycerol orally, or both agents, or neither. The illness was monitored with preset criteria. The primary outcome measures were the changes in plasma osmolality and in urine output. Results: Nine children received glycerol, 8 dexamethasone, 11 both agents, and 8 only placebo. The leading agents identified were Streptococcus pneumoniae, Haemophilus influenzae type b, and Staphylococcus aureus. Only the glycerol recipients increased plasma osmolality by up to 3% from the mean baseline of 294 mOsm/kg in the glycerol and 295 mOsm/kg in the glycerol-dexamethasone group. This change occurred within 6 hours, the critical period of treatment, and lasted <24 hours. Blood pressure was not affected, nor did urine output increase. The dexamethasone-only and placebo-only recipients showed immediate decrease in serum osmolality. Conclusions: Because excretion of the cerebrospinal fluid is inversely associated with plasma osmolality, we suggest that the glycerol-induced osmolality increase reduce the volume of cerebrospinal fluid, enhanced water movement back to the plasma by osmosis, increased cerebral blood flow, and thus, improved brain oxygenation." @default.
• W2077826743 created "2016-06-24" @default.
• W2077826743 creator A5023823125 @default.
• W2077826743 creator A5039291802 @default.
• W2077826743 creator A5068332954 @default.
• W2077826743 date "2008-10-01" @default.
• W2077826743 modified "2023-09-26" @default.
• W2077826743 title "Increase in Serum Osmolality Is Possible Mechanism for the Beneficial Effects of Glycerol in Childhood Bacterial Meningitis" @default.
• W2077826743 cites W1535823036 @default.
• W2077826743 cites W1966323763 @default.
• W2077826743 cites W1980010510 @default.
• W2077826743 cites W1992209211 @default.
• W2077826743 cites W1995363060 @default.
• W2077826743 cites W2005877446 @default.
• W2077826743 cites W2018556007 @default.
• W2077826743 cites W2022603159 @default.
• W2077826743 cites W2026596500 @default.
• W2077826743 cites W2028040325 @default.
• W2077826743 cites W2030440280 @default.
• W2077826743 cites W2030606595 @default.
• W2077826743 cites W2039825293 @default.
• W2077826743 cites W2040761545 @default.
• W2077826743 cites W2045172729 @default.
• W2077826743 cites W2045981461 @default.
• W2077826743 cites W2046765467 @default.
• W2077826743 cites W2051396400 @default.
• W2077826743 cites W2052148344 @default.
• W2077826743 cites W2065630969 @default.
• W2077826743 cites W2075632957 @default.
• W2077826743 cites W2076180384 @default.
• W2077826743 cites W2085568381 @default.
• W2077826743 cites W2087238266 @default.
• W2077826743 cites W2089929623 @default.
• W2077826743 cites W2093566442 @default.
• W2077826743 cites W2098024737 @default.
• W2077826743 cites W2116800859 @default.
• W2077826743 cites W2120965276 @default.
• W2077826743 cites W2134493024 @default.
• W2077826743 cites W2139793660 @default.
• W2077826743 cites W2142207521 @default.
• W2077826743 cites W2146759956 @default.
• W2077826743 cites W2153108266 @default.
• W2077826743 cites W2612661750 @default.
• W2077826743 cites W4247085835 @default.
• W2077826743 doi "https://doi.org/10.1097/inf.0b013e318175d177" @default.
• W2077826743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18776819" @default.
• W2077826743 hasPublicationYear "2008" @default.
• W2077826743 type Work @default.
• W2077826743 sameAs 2077826743 @default.
• W2077826743 citedByCount "35" @default.
• W2077826743 countsByYear W20778267432012 @default.
• W2077826743 countsByYear W20778267432013 @default.
• W2077826743 countsByYear W20778267432014 @default.
• W2077826743 countsByYear W20778267432015 @default.
• W2077826743 countsByYear W20778267432016 @default.
• W2077826743 countsByYear W20778267432018 @default.
• W2077826743 countsByYear W20778267432019 @default.
• W2077826743 countsByYear W20778267432020 @default.
• W2077826743 countsByYear W20778267432022 @default.
• W2077826743 countsByYear W20778267432023 @default.
• W2077826743 crossrefType "journal-article" @default.
• W2077826743 hasAuthorship W2077826743A5023823125 @default.
• W2077826743 hasAuthorship W2077826743A5039291802 @default.
• W2077826743 hasAuthorship W2077826743A5068332954 @default.
• W2077826743 hasConcept C126322002 @default.
• W2077826743 hasConcept C141071460 @default.
• W2077826743 hasConcept C142724271 @default.
• W2077826743 hasConcept C14705128 @default.
• W2077826743 hasConcept C204787440 @default.
• W2077826743 hasConcept C27081682 @default.
• W2077826743 hasConcept C2776370428 @default.
• W2077826743 hasConcept C2778534349 @default.
• W2077826743 hasConcept C2779651940 @default.
• W2077826743 hasConcept C2780026642 @default.
• W2077826743 hasConcept C2780401358 @default.
• W2077826743 hasConcept C2780762869 @default.
• W2077826743 hasConcept C2781026528 @default.
• W2077826743 hasConcept C42219234 @default.
• W2077826743 hasConcept C71924100 @default.
• W2077826743 hasConceptScore W2077826743C126322002 @default.
• W2077826743 hasConceptScore W2077826743C141071460 @default.
• W2077826743 hasConceptScore W2077826743C142724271 @default.
• W2077826743 hasConceptScore W2077826743C14705128 @default.
• W2077826743 hasConceptScore W2077826743C204787440 @default.
• W2077826743 hasConceptScore W2077826743C27081682 @default.
• W2077826743 hasConceptScore W2077826743C2776370428 @default.
• W2077826743 hasConceptScore W2077826743C2778534349 @default.
• W2077826743 hasConceptScore W2077826743C2779651940 @default.
• W2077826743 hasConceptScore W2077826743C2780026642 @default.
• W2077826743 hasConceptScore W2077826743C2780401358 @default.
• W2077826743 hasConceptScore W2077826743C2780762869 @default.
• W2077826743 hasConceptScore W2077826743C2781026528 @default.
• W2077826743 hasConceptScore W2077826743C42219234 @default.
• W2077826743 hasConceptScore W2077826743C71924100 @default.
• W2077826743 hasIssue "10" @default.
• W2077826743 hasLocation W20778267431 @default.
• W2077826743 hasLocation W20778267432 @default.
• W2077826743 hasOpenAccess W2077826743 @default.

• next