FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077832884> ?p ?o ?g. }

• W2077832884 abstract "The oral administration of vitamin B12 offers a potentially simpler and cheaper alternative to parenteral administration, but its effectiveness has not been definitively demonstrated. The following protocol was designed to compare the effectiveness of orally and intramuscularly administered vitamin B12 in the treatment of patients ≥65 years of age with vitamin B12 deficiency. The proposed study involves a controlled, randomised, multicentre, parallel, non-inferiority clinical trial lasting one year, involving 23 primary healthcare centres in the Madrid region (Spain), and patients ≥65 years of age. The minimum number of patients required for the study was calculated as 320 (160 in each arm). Bearing in mind an estimated 8-10% prevalence of vitamin B12 deficiency among the population of this age group, an initial sample of 3556 patients will need to be recruited. Eligible patients will be randomly assigned to one of the two treatment arms. In the intramuscular treatment arm, vitamin B12 will be administered as follows: 1 mg on alternate days in weeks 1 and 2, 1 mg/week in weeks 3–8,and 1 mg/month in weeks 9–52. In the oral arm, the vitamin will be administered as: 1 mg/day in weeks 1–8 and 1 mg/week in weeks 9–52. The main outcome variable to be monitored in both treatment arms is the normalisation of the serum vitamin B12 concentration at weeks 8, 26 and 52; the secondary outcome variables include the serum concentration of vitamin B12 (in pg/ml), adherence to treatment, quality of life (EuroQoL-5D questionnaire), patient 3satisfaction and patient preferences. All statistical tests will be performed with intention to treat and per protocol. Logistic regression with random effects will be used to adjust for prognostic factors. Confounding factors or factors that might alter the effect recorded will be taken into account in analyses. The results of this study should help establish, taking quality of life into account, whether the oral administration of vitamin B12 is an effective alternative to its intramuscular administration. If this administration route is effective, it should provide a cheaper means of treating vitamin B12 deficiency while inducing fewer adverse effects. Having such an alternative would also allow patient preferences to be taken into consideration at the time of prescribing treatment. This trial has been registered with ClinicalTrials.gov, number NCT 01476007, and under EUDRACT number 2010-024129-20." @default.
• W2077832884 created "2016-06-24" @default.
• W2077832884 creator A5000164723 @default.
• W2077832884 creator A5004174868 @default.
• W2077832884 creator A5009616951 @default.
• W2077832884 creator A5010710796 @default.
• W2077832884 creator A5011250094 @default.
• W2077832884 creator A5011909241 @default.
• W2077832884 creator A5019321971 @default.
• W2077832884 creator A5021635289 @default.
• W2077832884 creator A5022735225 @default.
• W2077832884 creator A5026000449 @default.
• W2077832884 creator A5040791834 @default.
• W2077832884 creator A5042942229 @default.
• W2077832884 creator A5050220118 @default.
• W2077832884 creator A5050234742 @default.
• W2077832884 creator A5052977402 @default.
• W2077832884 creator A5054830776 @default.
• W2077832884 creator A5060085015 @default.
• W2077832884 creator A5062784067 @default.
• W2077832884 creator A5062835899 @default.
• W2077832884 creator A5064333753 @default.
• W2077832884 creator A5067478768 @default.
• W2077832884 creator A5067647935 @default.
• W2077832884 creator A5070126261 @default.
• W2077832884 creator A5071087621 @default.
• W2077832884 creator A5071123183 @default.
• W2077832884 creator A5071583127 @default.
• W2077832884 creator A5073357881 @default.
• W2077832884 creator A5082955786 @default.
• W2077832884 creator A5083277360 @default.
• W2077832884 creator A5084502609 @default.
• W2077832884 creator A5087514617 @default.
• W2077832884 creator A5091654963 @default.
• W2077832884 creator A5091720151 @default.
• W2077832884 date "2012-05-31" @default.
• W2077832884 modified "2023-10-01" @default.
• W2077832884 title "Oral versus intramuscular administration of vitamin B12 for the treatment of patients with vitamin B12 deficiency: a pragmatic, randomised, multicentre, non-inferiority clinical trial undertaken in the primary healthcare setting (Project OB12)" @default.
• W2077832884 cites W1771053245 @default.
• W2077832884 cites W1953523985 @default.
• W2077832884 cites W1965554155 @default.
• W2077832884 cites W1966087339 @default.
• W2077832884 cites W1981751104 @default.
• W2077832884 cites W2004280378 @default.
• W2077832884 cites W2007239126 @default.
• W2077832884 cites W2008976298 @default.
• W2077832884 cites W2009031512 @default.
• W2077832884 cites W2012373325 @default.
• W2077832884 cites W2019173426 @default.
• W2077832884 cites W2022131347 @default.
• W2077832884 cites W2022968619 @default.
• W2077832884 cites W2028746523 @default.
• W2077832884 cites W2065651584 @default.
• W2077832884 cites W2069091142 @default.
• W2077832884 cites W2078842266 @default.
• W2077832884 cites W2084639013 @default.
• W2077832884 cites W2092377733 @default.
• W2077832884 cites W2108264134 @default.
• W2077832884 cites W2111194405 @default.
• W2077832884 cites W2119369015 @default.
• W2077832884 cites W2125669371 @default.
• W2077832884 cites W2134584460 @default.
• W2077832884 cites W2161798329 @default.
• W2077832884 cites W2164518728 @default.
• W2077832884 cites W2165790578 @default.
• W2077832884 cites W2170781522 @default.
• W2077832884 cites W2186657631 @default.
• W2077832884 cites W4318598739 @default.
• W2077832884 doi "https://doi.org/10.1186/1471-2458-12-394" @default.
• W2077832884 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3403849" @default.
• W2077832884 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22650964" @default.
• W2077832884 hasPublicationYear "2012" @default.
• W2077832884 type Work @default.
• W2077832884 sameAs 2077832884 @default.
• W2077832884 citedByCount "24" @default.
• W2077832884 countsByYear W20778328842013 @default.
• W2077832884 countsByYear W20778328842014 @default.
• W2077832884 countsByYear W20778328842015 @default.
• W2077832884 countsByYear W20778328842016 @default.
• W2077832884 countsByYear W20778328842017 @default.
• W2077832884 countsByYear W20778328842018 @default.
• W2077832884 countsByYear W20778328842019 @default.
• W2077832884 countsByYear W20778328842020 @default.
• W2077832884 countsByYear W20778328842021 @default.
• W2077832884 countsByYear W20778328842022 @default.
• W2077832884 countsByYear W20778328842023 @default.
• W2077832884 crossrefType "journal-article" @default.
• W2077832884 hasAuthorship W2077832884A5000164723 @default.
• W2077832884 hasAuthorship W2077832884A5004174868 @default.
• W2077832884 hasAuthorship W2077832884A5009616951 @default.
• W2077832884 hasAuthorship W2077832884A5010710796 @default.
• W2077832884 hasAuthorship W2077832884A5011250094 @default.
• W2077832884 hasAuthorship W2077832884A5011909241 @default.
• W2077832884 hasAuthorship W2077832884A5019321971 @default.
• W2077832884 hasAuthorship W2077832884A5021635289 @default.
• W2077832884 hasAuthorship W2077832884A5022735225 @default.
• W2077832884 hasAuthorship W2077832884A5026000449 @default.
• W2077832884 hasAuthorship W2077832884A5040791834 @default.
• W2077832884 hasAuthorship W2077832884A5042942229 @default.
• W2077832884 hasAuthorship W2077832884A5050220118 @default.

• next