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- W2077836680 abstract "This study aimed to monitor the accumulation of endogenous protoporphyrin-IX (PpIX) in rat Leydig cells (R(2)C) under the effect of 5-aminolevulinic acid (ALA) and various concentrations of tramadol, an analgesic drug.Pain during photodynamic treatment with ALA is one of the adverse effects of this new treatment to eradicate tumor cells. ALA is utilized in photodynamic diagnosis and therapy (PDT) as a compound capable of augmenting the intracellular pool of PpIX, which exhibits properties of a photosensitizer.Cellular content of PpIX was determined following incubation of the cells for 1 and 2 h in culture medium that contained ALA and different concentrations of tramadol. The amount of PpIX was determined using fluorescent technique under a confocal microscope (laser wavelength 458 nm and filter LP 585 nm), and evaluated using CytFlu 1.2 software.After 1 h of incubation, no significant alterations were noted in the cellular PpIX concentration. However, 2 h of incubation resulted in a significant increase (p < 0.05) in PpIX fluorescence inside the cells, when the medium contained ALA and tramadol in concentrations ranging from 1-2 mg/1 mL.The results suggested that in R(2)C cells, exogenous ALA and tramadol induced protoporphyrin accumulation. This information is useful for two reasons. First, it may help to diminish pain after ALA-PDT treatment; and second, it allows the use of lower concentrations of ALA during therapy." @default.
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- W2077836680 date "2007-12-01" @default.
- W2077836680 modified "2023-09-23" @default.
- W2077836680 title "Accumulation of Protoporphyrin-IX in Rat Leydig Cells Following Induction by 5-Aminolevulinic Acid and Tramadol" @default.
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- W2077836680 doi "https://doi.org/10.1089/pho.2007.2113" @default.
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