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- W2077843887 abstract "A girl aged 8 yrs had suffered from periodic attacks of vomiting, psychotic depression and hypertension lasting for 5 to 6 days at monthly intervals since 16 months before admission. At the initiation of the attack, serum corticotropin (ACTH) and vaso-pressin (ADH) levels were prominently increased (610 pg/ml and 41 uU/ml respectively) despite normal plasma osmolality, which consequently produced hypertension (160/110 mmHg), hypercortisolemia and hyponatremia. Serum prolactin was also increased (91 ng/ml). During the attack, urinary excretion of epinephrine (E) and nor-epinephrine (NE) was elevated while that of dopamine (D) was reduced, resulting in marked rise in E+NE/D ratio (0.8 − 4.5), which decreased to normal level when symptoms disappeared (0.08 − 0.17). Provocation of the attack by hypertonic saline infusion or by metyrapone administration was not successful. Infusion of somatostatin at early stage of the attack suppressed the symptoms and chronic administration of methyl-DOPA with reserpine effectively inhibited the recurrence of the episodes. Her symptoms appear to be induced by periodic discharge of ACTH and ADH. Although the exact cause of this syndrome is unknown, disturbance in catechol-aminergic mechanism in hypothalamus is postulated." @default.
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- W2077843887 date "1981-12-01" @default.
- W2077843887 modified "2023-09-26" @default.
- W2077843887 title "A syndrome of periodic ACTH and ADH discharge" @default.
- W2077843887 doi "https://doi.org/10.1203/00006450-198112000-00165" @default.
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