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- W2077854595 endingPage "1896" @default.
- W2077854595 startingPage "1889" @default.
- W2077854595 abstract "The contents of the prothoracic defence glands of water beetles are highly physiologically active substances. In beetles of the subfamily Dytiscinae the principal components are steroids. They are specific poisons by which the beetles protect themselves against larger enemies like pike, trout, and frogs. Non-toxic substances against fishes are the main components from the prothoracic glands of water beetles of the subfamily Colymbetinae. Besides steroids, Ilybius fenestratus produces mainly 2-carbmethoxy-8-hydroxyquinoline which causes clonic spasms in mice. The contents of the prothoracic defence glands of Colymbetes fuscus contrast very strikingly with this alkaloid and insect steroids. The secretion is clear and soluble in water. The total secretion showed a blood pressure lowering action when it was injected into the veins of rats. The active substances could be separated out by column chromatography on Sephadex G-25. Two out of six fractions, A-F, namely fractions C and D with their molecular weight a little higher than 700, were active; fraction C was investigated thoroughly. After hydrolysis we found at least four amino acids, sugar, phosphate, and adenin which was identified by u.v. and mass-spectrometry. These results are consistent with the structure of a nucleoproteid to which we gave the name ‘Colymbetin’. C. fuscus is amphibious and is well equipped, therefore, with Colymbetin to defend itself against predatory small mammals." @default.
- W2077854595 created "2016-06-24" @default.
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- W2077854595 date "1971-10-01" @default.
- W2077854595 modified "2023-09-29" @default.
- W2077854595 title "Colymbetin, a new defensive substance of the water beetle, Colymbetes fuscus, that lowers blood pressure—LII" @default.
- W2077854595 cites W2023166630 @default.
- W2077854595 doi "https://doi.org/10.1016/0022-1910(71)90133-8" @default.
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