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• W2077855209 abstract "A comparative study which compared PPD skin testing inserted according to the French Society of Pneumology's recommendations and interferon gamma release assay (IGRA) (QuantiFERON® TB Gold In-tube, QF–TB–IT, Cellestis, Carnegie, Australia) was performed during a tuberculosis contact investigation in our hospital. Nineteen French health-care workers (HCWs) volunteered to participate. All of the HCW enrolled were BCG vaccinated and had a normal chest X-ray at entry. Among the HCW, 68.4% were TST positive. By comparison, only 31.6% had a positive QF-TB-IT result. We took advantage of the negative tube and the corresponding plasma for antibody detection by ELISA. None were ELISA positive. Fourteen HCWs were followed up. None of the HCWs accepted a course of antiTB chemoprophylaxis. Despite the difficulty in establishing a trend in kinetics, we saw the complexity of interpretation of a dynamic T-cell response after contact with an index case. This initial and first French picture provides us with the observation that only 44% of TST-positive HCW were IGRA positive, and the IGRA test allowed the detection of LTBI in two TST negative HCWs. Une étude comparative entre le test à la tuberculine (TST) pratiqué selon les recommandations de la Société française de pneumologie et le test Quantiféron® TB Gold in tube (QF-TB-IT, Cellestis, Carnegie, Australie) a été réalisée lors d’une enquête autour d’un cas de tuberculose bacillifère dans notre hôpital. Dix-neuf personnels soignants ont accepté de participer à cette étude. 100 % étaient vaccinés par le BCG et présentaient une radiographie thoracique normale. Le personnel présentait un TST positif à 68,4 %. Seuls 31,6 % avait un QF-TB-IT positif. Nous avons utilisé le plasma recueilli dans le tube négatif pour réaliser également la recherche d’anticorps spécifique par Elisa. Aucun des personnels soignants n’était positif. Parmi les 19 personnels inclus, seuls 14 ont été suivis. Aucun n’avait accepté de recevoir une chimioprophylaxie. Sans définir une réelle cinétique, nous avons observé toute la difficulté d’interpréter la réponse dynamique lymphocytes T-IFNγ après contact avec un cas index. Cette première étude réalisée au sein d’un hôpital français nous montre que 44 % des personnels soignants TST positif était QF-TB-IT positif ; et que le QF-TB-IT a permis la détection de tuberculose infection latente chez deux personnels soignants TST négatif." @default.
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• W2077855209 date "2009-05-01" @default.
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• W2077855209 title "IFNγ and antibody responses among French nurses during a tuberculosis contact tracing investigation" @default.
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• W2077855209 doi "https://doi.org/10.1016/j.patbio.2008.02.010" @default.
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