FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077855603> ?p ?o ?g. }

• W2077855603 endingPage "876" @default.
• W2077855603 startingPage "871" @default.
• W2077855603 abstract "Cytotoxic T lymphocyte (CTL)-mediated destruction of allogeneic vascular endothelium is important in the pathogenesis of both acute and chronic allograft rejection. Despite the importance of this phenomenon, the effector mechanisms responsible for endothelial cell killing are not well defined, and conflicting conclusions have been reached based on variation in experimental methodology.We used a recently described method for isolating mouse vascular endothelium to evaluate endothelial cell lysis by CTLs. Endothelial cell destruction was assessed in vitro both by 51Cr release and DNA fragmentation using wild-type and lpr (Fas deficient) endothelium of C3H/HeJ (H2(k)) mice by MHC alloantigen-specific T cells of wild-type, gld (Fas ligand deficient), and perforin-deficient mice on a C57BL/6 (H2(b)) background.Although maximal lysis of 56.6+/-0.8% was seen when using wild-type targets and effectors, only a moderate decrease in apoptosis to 37.6+/-4.0% was detected when the Fas/Fas ligand death receptor pathway was eliminated. This decrease in cytotoxicity occurred despite the preserved functional capacity of this pathway. Alternatively, a significant decrease in cytotoxicity to 17.4+/-4.7% was seen when the perforin/granzyme exocytosis pathway was eliminated.These data indicate that CTLs destroy vascular endothelium primarily by the perforin/granzyme exocytosis pathway with only a minor contribution to apoptosis by the Fas/Fas ligand death receptor pathway. These data are critical for the proper interpretation of studies evaluating acute and chronic allograft rejection and for the design of rational strategies to ameliorate vascular injury concomitant to the rejection process." @default.
• W2077855603 created "2016-06-24" @default.
• W2077855603 creator A5010594053 @default.
• W2077855603 creator A5037613894 @default.
• W2077855603 creator A5044397265 @default.
• W2077855603 creator A5049867340 @default.
• W2077855603 creator A5051902236 @default.
• W2077855603 creator A5054858357 @default.
• W2077855603 creator A5055841327 @default.
• W2077855603 creator A5069528979 @default.
• W2077855603 creator A5069996881 @default.
• W2077855603 creator A5073923248 @default.
• W2077855603 date "2002-09-01" @default.
• W2077855603 modified "2023-10-17" @default.
• W2077855603 title "Mechanism of T cell???mediated endothelial apoptosis1." @default.
• W2077855603 cites W1523840697 @default.
• W2077855603 cites W1556867369 @default.
• W2077855603 cites W1642763135 @default.
• W2077855603 cites W1964432880 @default.
• W2077855603 cites W1974389600 @default.
• W2077855603 cites W1975336660 @default.
• W2077855603 cites W1977322584 @default.
• W2077855603 cites W1981182552 @default.
• W2077855603 cites W1983077763 @default.
• W2077855603 cites W1985253103 @default.
• W2077855603 cites W2019789822 @default.
• W2077855603 cites W2037865420 @default.
• W2077855603 cites W2044921575 @default.
• W2077855603 cites W2045843248 @default.
• W2077855603 cites W2047366579 @default.
• W2077855603 cites W2049902401 @default.
• W2077855603 cites W2060622425 @default.
• W2077855603 cites W2067245803 @default.
• W2077855603 cites W2067739721 @default.
• W2077855603 cites W2068069867 @default.
• W2077855603 cites W2072079193 @default.
• W2077855603 cites W2074562878 @default.
• W2077855603 cites W2078374858 @default.
• W2077855603 cites W2082079879 @default.
• W2077855603 cites W2097810231 @default.
• W2077855603 cites W2100359443 @default.
• W2077855603 cites W2103479357 @default.
• W2077855603 cites W2109334068 @default.
• W2077855603 cites W2121563199 @default.
• W2077855603 cites W2139085980 @default.
• W2077855603 cites W2139640512 @default.
• W2077855603 cites W2171634793 @default.
• W2077855603 cites W4243390492 @default.
• W2077855603 doi "https://doi.org/10.1097/00007890-200209270-00022" @default.
• W2077855603 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12364869" @default.
• W2077855603 hasPublicationYear "2002" @default.
• W2077855603 type Work @default.
• W2077855603 sameAs 2077855603 @default.
• W2077855603 citedByCount "47" @default.
• W2077855603 countsByYear W20778556032012 @default.
• W2077855603 countsByYear W20778556032013 @default.
• W2077855603 countsByYear W20778556032014 @default.
• W2077855603 countsByYear W20778556032015 @default.
• W2077855603 countsByYear W20778556032016 @default.
• W2077855603 countsByYear W20778556032017 @default.
• W2077855603 countsByYear W20778556032018 @default.
• W2077855603 countsByYear W20778556032019 @default.
• W2077855603 countsByYear W20778556032021 @default.
• W2077855603 countsByYear W20778556032022 @default.
• W2077855603 crossrefType "journal-article" @default.
• W2077855603 hasAuthorship W2077855603A5010594053 @default.
• W2077855603 hasAuthorship W2077855603A5037613894 @default.
• W2077855603 hasAuthorship W2077855603A5044397265 @default.
• W2077855603 hasAuthorship W2077855603A5049867340 @default.
• W2077855603 hasAuthorship W2077855603A5051902236 @default.
• W2077855603 hasAuthorship W2077855603A5054858357 @default.
• W2077855603 hasAuthorship W2077855603A5055841327 @default.
• W2077855603 hasAuthorship W2077855603A5069528979 @default.
• W2077855603 hasAuthorship W2077855603A5069996881 @default.
• W2077855603 hasAuthorship W2077855603A5073923248 @default.
• W2077855603 hasConcept C123012128 @default.
• W2077855603 hasConcept C134018914 @default.
• W2077855603 hasConcept C154317977 @default.
• W2077855603 hasConcept C167672396 @default.
• W2077855603 hasConcept C183193105 @default.
• W2077855603 hasConcept C190283241 @default.
• W2077855603 hasConcept C202751555 @default.
• W2077855603 hasConcept C203014093 @default.
• W2077855603 hasConcept C2776062744 @default.
• W2077855603 hasConcept C2776090121 @default.
• W2077855603 hasConcept C2776992346 @default.
• W2077855603 hasConcept C2780380082 @default.
• W2077855603 hasConcept C31573885 @default.
• W2077855603 hasConcept C502942594 @default.
• W2077855603 hasConcept C55493867 @default.
• W2077855603 hasConcept C66008609 @default.
• W2077855603 hasConcept C86803240 @default.
• W2077855603 hasConcept C8891405 @default.
• W2077855603 hasConcept C95444343 @default.
• W2077855603 hasConceptScore W2077855603C123012128 @default.
• W2077855603 hasConceptScore W2077855603C134018914 @default.
• W2077855603 hasConceptScore W2077855603C154317977 @default.
• W2077855603 hasConceptScore W2077855603C167672396 @default.

• next