FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077855841> ?p ?o ?g. }

• W2077855841 endingPage "884" @default.
• W2077855841 startingPage "874" @default.
• W2077855841 abstract "Four sensitive, selective and precise stability-indicating methods for the determination of Clopidogrel Bisulfate (CLP) in presence of its alkaline degradate and in pharmaceutical formulations were developed and validated. Method A is a second derivative (D(2)) spectrophotometric one, which allows the determination of CLP in presence of its alkaline degradate at 219.6, 270.6, 274.2 and 278.4 nm (corresponding to zero-crossing of the degradate) over a concentration range of 4-37 microg mL(-1) with mean percentage recoveries 99.81+/-0.893, 99.72+/-0.668, 99.88+/-0.526 and 100.46+/-0.646, respectively. CLP can be determined in the presence of up to 65% of its degradate. D(2) method was used to study the kinetic of CLP alkaline degradation that was found to follow a first-order reaction. The t(1/2) was 6.42 h while K (reaction rate constant) was 0.1080 mol/h. Method B is the first derivative of the ratio spectra (DD(1)) spectrophotometric method, by measuring the peak amplitude at 217.6 and 229.4 nm using acetonitrile and CLP can be determined in the presence of up to 70% of its degradate. The linearity range was 5-38 microg mL(-1) with mean percentage recoveries 99.88+/-0.909 and 99.70+/-0.952, respectively. Method C based on the determination of CLP by the bivariate calibration depending on simple mathematic algorithm which provides simplicity and rapidity. The method depends on quantitative evaluation of the absorbance at 210 and 225 nm over a concentration range 5-38 microg mL(-1) with mean percentage recovery 99.27+/-1.115. CLP can be determined in the presence of up to 70% of its degradate. Method D is a TLC-densitometric one, where CLP was separated from its degradate on silica gel plates using hexane:methanol:ethyl acetate (8.7:1:0.3, v/v/v) as a developing system. This method depends on quantitative densitometric evaluation of thin layer chromatogram of CLP at 248 nm over a concentration range of 0.6-3 microg/band with mean percentage recovery 99.97+/-1.161. CLP can be determined in the presence of up to 90% of its alkaline degradate. The selectivity of the proposed methods was checked using laboratory prepared mixtures. The proposed methods have been successfully applied to the analysis of CLP in pharmaceutical dosage forms without interference from other dosage form additives and the results were statistically compared with the official method." @default.
• W2077855841 created "2016-06-24" @default.
• W2077855841 creator A5007021496 @default.
• W2077855841 creator A5032574431 @default.
• W2077855841 creator A5060351897 @default.
• W2077855841 creator A5073807774 @default.
• W2077855841 date "2009-05-15" @default.
• W2077855841 modified "2023-09-25" @default.
• W2077855841 title "Spectrophotometric and spectrodensitometric determination of Clopidogrel Bisulfate with kinetic study of its alkaline degradation" @default.
• W2077855841 cites W1415139109 @default.
• W2077855841 cites W1562659276 @default.
• W2077855841 cites W1964549091 @default.
• W2077855841 cites W1973913628 @default.
• W2077855841 cites W1999193583 @default.
• W2077855841 cites W2006243616 @default.
• W2077855841 cites W2014455125 @default.
• W2077855841 cites W2036910908 @default.
• W2077855841 cites W2039496408 @default.
• W2077855841 cites W2053034538 @default.
• W2077855841 cites W2064092412 @default.
• W2077855841 cites W2072679428 @default.
• W2077855841 cites W2080188883 @default.
• W2077855841 cites W2087920030 @default.
• W2077855841 cites W2091269995 @default.
• W2077855841 cites W2140739606 @default.
• W2077855841 cites W2142841281 @default.
• W2077855841 doi "https://doi.org/10.1016/j.talanta.2008.12.064" @default.
• W2077855841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19269444" @default.
• W2077855841 hasPublicationYear "2009" @default.
• W2077855841 type Work @default.
• W2077855841 sameAs 2077855841 @default.
• W2077855841 citedByCount "21" @default.
• W2077855841 countsByYear W20778558412012 @default.
• W2077855841 countsByYear W20778558412013 @default.
• W2077855841 countsByYear W20778558412014 @default.
• W2077855841 countsByYear W20778558412015 @default.
• W2077855841 countsByYear W20778558412017 @default.
• W2077855841 countsByYear W20778558412018 @default.
• W2077855841 countsByYear W20778558412020 @default.
• W2077855841 countsByYear W20778558412022 @default.
• W2077855841 countsByYear W20778558412023 @default.
• W2077855841 crossrefType "journal-article" @default.
• W2077855841 hasAuthorship W2077855841A5007021496 @default.
• W2077855841 hasAuthorship W2077855841A5032574431 @default.
• W2077855841 hasAuthorship W2077855841A5060351897 @default.
• W2077855841 hasAuthorship W2077855841A5073807774 @default.
• W2077855841 hasConcept C106159729 @default.
• W2077855841 hasConcept C111771559 @default.
• W2077855841 hasConcept C113196181 @default.
• W2077855841 hasConcept C119128265 @default.
• W2077855841 hasConcept C13965031 @default.
• W2077855841 hasConcept C162324750 @default.
• W2077855841 hasConcept C185592680 @default.
• W2077855841 hasConcept C23531484 @default.
• W2077855841 hasConcept C2777463227 @default.
• W2077855841 hasConcept C2779679103 @default.
• W2077855841 hasConcept C2780343419 @default.
• W2077855841 hasConcept C41008148 @default.
• W2077855841 hasConcept C43617362 @default.
• W2077855841 hasConcept C76155785 @default.
• W2077855841 hasConcept C98015330 @default.
• W2077855841 hasConceptScore W2077855841C106159729 @default.
• W2077855841 hasConceptScore W2077855841C111771559 @default.
• W2077855841 hasConceptScore W2077855841C113196181 @default.
• W2077855841 hasConceptScore W2077855841C119128265 @default.
• W2077855841 hasConceptScore W2077855841C13965031 @default.
• W2077855841 hasConceptScore W2077855841C162324750 @default.
• W2077855841 hasConceptScore W2077855841C185592680 @default.
• W2077855841 hasConceptScore W2077855841C23531484 @default.
• W2077855841 hasConceptScore W2077855841C2777463227 @default.
• W2077855841 hasConceptScore W2077855841C2779679103 @default.
• W2077855841 hasConceptScore W2077855841C2780343419 @default.
• W2077855841 hasConceptScore W2077855841C41008148 @default.
• W2077855841 hasConceptScore W2077855841C43617362 @default.
• W2077855841 hasConceptScore W2077855841C76155785 @default.
• W2077855841 hasConceptScore W2077855841C98015330 @default.
• W2077855841 hasIssue "3" @default.
• W2077855841 hasLocation W20778558411 @default.
• W2077855841 hasLocation W20778558412 @default.
• W2077855841 hasOpenAccess W2077855841 @default.
• W2077855841 hasPrimaryLocation W20778558411 @default.
• W2077855841 hasRelatedWork W139793748 @default.
• W2077855841 hasRelatedWork W1585006142 @default.
• W2077855841 hasRelatedWork W1982080709 @default.
• W2077855841 hasRelatedWork W2062853590 @default.
• W2077855841 hasRelatedWork W2357937215 @default.
• W2077855841 hasRelatedWork W2385035341 @default.
• W2077855841 hasRelatedWork W2887045667 @default.
• W2077855841 hasRelatedWork W3104304894 @default.
• W2077855841 hasRelatedWork W3160617554 @default.
• W2077855841 hasRelatedWork W4200599765 @default.
• W2077855841 hasVolume "78" @default.
• W2077855841 isParatext "false" @default.
• W2077855841 isRetracted "false" @default.
• W2077855841 magId "2077855841" @default.
• W2077855841 workType "article" @default.