Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077855921> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2077855921 endingPage "409" @default.
- W2077855921 startingPage "400" @default.
- W2077855921 abstract "This paper concerns the rate of birth defects that is induced by hyperthermic conditions during gestation. These defects occur with low rates under apparently normal physiologic conditions, but with substantially higher rates with appropriate timing of a hyperthermic event during gestation. The concept of “free energy of activation” is invoked to explain not only the background rate but also the effect of a short-term, acute (additive) thermal dosing at a highly heat-sensitive stage of embryogenesis. In this respect, this paper is both retrospective and prospective in approach. It briefly and retrospectively addresses the historical data in this area and then, following a novel mathematical procedure whereby the activation energy for a specific type of hyperthermia-induced birth defect is determined, prospectively applies this information to predict what the outcomes would be in a clinical situation such as obstetric diagnostic ultrasound where it is known that the clinical procedure can involve a temperature increment for a specific duration. A major outcome of this review is that there appear to be no thresholds for hyperthermic events, that any temperature elevation for any duration during pregnancy has some potential for inducing a deleterious effect. The paper includes an analysis that for the first time allows a calculation of risk for such defined thermal insults, with broader implications for any natural or other clinical situation in which the temperature of the embryo or fetus is raised above the normal physiologic level. The topic of hyperthermia-induced birth defects and related activation energies needs thorough, long-term testing of this prospective position." @default.
- W2077855921 created "2016-06-24" @default.
- W2077855921 creator A5023608931 @default.
- W2077855921 creator A5079442987 @default.
- W2077855921 creator A5087749599 @default.
- W2077855921 date "2005-07-01" @default.
- W2077855921 modified "2023-10-16" @default.
- W2077855921 title "A new perspective on hyperthermia-induced birth defects: The role of activation energy and its relation to obstetric ultrasound" @default.
- W2077855921 cites W1964872165 @default.
- W2077855921 cites W1994248513 @default.
- W2077855921 cites W2000144812 @default.
- W2077855921 cites W2004114805 @default.
- W2077855921 cites W2008236818 @default.
- W2077855921 cites W2011977776 @default.
- W2077855921 cites W2012644846 @default.
- W2077855921 cites W2012833822 @default.
- W2077855921 cites W2014128732 @default.
- W2077855921 cites W2022299013 @default.
- W2077855921 cites W2035246735 @default.
- W2077855921 cites W2043402257 @default.
- W2077855921 cites W2057226779 @default.
- W2077855921 cites W2067362539 @default.
- W2077855921 cites W2070822996 @default.
- W2077855921 cites W2085975308 @default.
- W2077855921 cites W2092467117 @default.
- W2077855921 cites W2094520198 @default.
- W2077855921 cites W2101109530 @default.
- W2077855921 cites W2110899227 @default.
- W2077855921 cites W2124124867 @default.
- W2077855921 cites W2138853270 @default.
- W2077855921 cites W2144726034 @default.
- W2077855921 cites W2161382930 @default.
- W2077855921 cites W2164071690 @default.
- W2077855921 cites W1650299914 @default.
- W2077855921 doi "https://doi.org/10.1016/j.jtherbio.2005.05.001" @default.
- W2077855921 hasPublicationYear "2005" @default.
- W2077855921 type Work @default.
- W2077855921 sameAs 2077855921 @default.
- W2077855921 citedByCount "15" @default.
- W2077855921 countsByYear W20778559212012 @default.
- W2077855921 countsByYear W20778559212013 @default.
- W2077855921 countsByYear W20778559212014 @default.
- W2077855921 countsByYear W20778559212016 @default.
- W2077855921 countsByYear W20778559212017 @default.
- W2077855921 countsByYear W20778559212023 @default.
- W2077855921 crossrefType "journal-article" @default.
- W2077855921 hasAuthorship W2077855921A5023608931 @default.
- W2077855921 hasAuthorship W2077855921A5079442987 @default.
- W2077855921 hasAuthorship W2077855921A5087749599 @default.
- W2077855921 hasConcept C126322002 @default.
- W2077855921 hasConcept C126838900 @default.
- W2077855921 hasConcept C143753070 @default.
- W2077855921 hasConcept C172680121 @default.
- W2077855921 hasConcept C2779234561 @default.
- W2077855921 hasConcept C2779949491 @default.
- W2077855921 hasConcept C46973012 @default.
- W2077855921 hasConcept C54355233 @default.
- W2077855921 hasConcept C71924100 @default.
- W2077855921 hasConcept C86803240 @default.
- W2077855921 hasConceptScore W2077855921C126322002 @default.
- W2077855921 hasConceptScore W2077855921C126838900 @default.
- W2077855921 hasConceptScore W2077855921C143753070 @default.
- W2077855921 hasConceptScore W2077855921C172680121 @default.
- W2077855921 hasConceptScore W2077855921C2779234561 @default.
- W2077855921 hasConceptScore W2077855921C2779949491 @default.
- W2077855921 hasConceptScore W2077855921C46973012 @default.
- W2077855921 hasConceptScore W2077855921C54355233 @default.
- W2077855921 hasConceptScore W2077855921C71924100 @default.
- W2077855921 hasConceptScore W2077855921C86803240 @default.
- W2077855921 hasIssue "5" @default.
- W2077855921 hasLocation W20778559211 @default.
- W2077855921 hasOpenAccess W2077855921 @default.
- W2077855921 hasPrimaryLocation W20778559211 @default.
- W2077855921 hasRelatedWork W1996912214 @default.
- W2077855921 hasRelatedWork W2004317605 @default.
- W2077855921 hasRelatedWork W2017292534 @default.
- W2077855921 hasRelatedWork W2034531855 @default.
- W2077855921 hasRelatedWork W2041269450 @default.
- W2077855921 hasRelatedWork W2046375634 @default.
- W2077855921 hasRelatedWork W2063828562 @default.
- W2077855921 hasRelatedWork W2070822996 @default.
- W2077855921 hasRelatedWork W2107304850 @default.
- W2077855921 hasRelatedWork W2397830406 @default.
- W2077855921 hasVolume "30" @default.
- W2077855921 isParatext "false" @default.
- W2077855921 isRetracted "false" @default.
- W2077855921 magId "2077855921" @default.
- W2077855921 workType "article" @default.