Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077858580> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2077858580 endingPage "280" @default.
- W2077858580 startingPage "269" @default.
- W2077858580 abstract "For the evaluation of eye irritation, one in vitro alternative test may not completely replace the Draize test. Therefore, a tiered approach combining several in vitro assays, including cytotoxicity assays, is proposed in order to estimate the eye irritation potential of a wide range of chemical classes. The Short Time Exposure (STE) test, a relatively newer alternative eye irritation test, involves exposing Statens seruminstitut rabbit cornea (SIRC) cells for 5 min to two concentrations (5% and 0.05%) of test material. In the present study, we examined the predictive capacity of a tiered approach analyzing the results from the STE test and then the results of the bovine corneal opacity and permeability (BCOP) assay for assessing globally harmonized system (GHS) eye irritation rankings of various chemicals. The accuracy of predicting the GHS rankings was slightly improved when the tiered approach combination of STE test and BCOP assay was used compared to when the STE test irritation rank classification was used alone. Moreover, the under prediction rate was substantially improved when this tiered approach was used. From these results, the tiered approach of combining the data analysis of the STE test and BCOP assay might be a promising alternative eye irritation test strategy." @default.
- W2077858580 created "2016-06-24" @default.
- W2077858580 creator A5005936159 @default.
- W2077858580 creator A5046717254 @default.
- W2077858580 creator A5049359241 @default.
- W2077858580 creator A5059947593 @default.
- W2077858580 creator A5064282428 @default.
- W2077858580 creator A5071598908 @default.
- W2077858580 creator A5087919108 @default.
- W2077858580 date "2012-01-01" @default.
- W2077858580 modified "2023-09-23" @default.
- W2077858580 title "A tiered approach combining the short time exposure (STE) test and the bovine corneal opacity and permeability (BCOP) assay for predicting eye irritation potential of chemicals" @default.
- W2077858580 cites W1978761477 @default.
- W2077858580 cites W2008685550 @default.
- W2077858580 cites W2018166772 @default.
- W2077858580 cites W2036170607 @default.
- W2077858580 cites W2049968169 @default.
- W2077858580 cites W2093808180 @default.
- W2077858580 cites W2094432400 @default.
- W2077858580 cites W2103150129 @default.
- W2077858580 cites W2159141432 @default.
- W2077858580 cites W2936070105 @default.
- W2077858580 cites W1723317934 @default.
- W2077858580 doi "https://doi.org/10.2131/jts.37.269" @default.
- W2077858580 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22467017" @default.
- W2077858580 hasPublicationYear "2012" @default.
- W2077858580 type Work @default.
- W2077858580 sameAs 2077858580 @default.
- W2077858580 citedByCount "20" @default.
- W2077858580 countsByYear W20778585802012 @default.
- W2077858580 countsByYear W20778585802013 @default.
- W2077858580 countsByYear W20778585802015 @default.
- W2077858580 countsByYear W20778585802017 @default.
- W2077858580 countsByYear W20778585802018 @default.
- W2077858580 countsByYear W20778585802019 @default.
- W2077858580 countsByYear W20778585802020 @default.
- W2077858580 countsByYear W20778585802021 @default.
- W2077858580 countsByYear W20778585802022 @default.
- W2077858580 countsByYear W20778585802023 @default.
- W2077858580 crossrefType "journal-article" @default.
- W2077858580 hasAuthorship W2077858580A5005936159 @default.
- W2077858580 hasAuthorship W2077858580A5046717254 @default.
- W2077858580 hasAuthorship W2077858580A5049359241 @default.
- W2077858580 hasAuthorship W2077858580A5059947593 @default.
- W2077858580 hasAuthorship W2077858580A5064282428 @default.
- W2077858580 hasAuthorship W2077858580A5071598908 @default.
- W2077858580 hasAuthorship W2077858580A5087919108 @default.
- W2077858580 hasBestOaLocation W20778585801 @default.
- W2077858580 hasConcept C118487528 @default.
- W2077858580 hasConcept C185592680 @default.
- W2077858580 hasConcept C202751555 @default.
- W2077858580 hasConcept C203014093 @default.
- W2077858580 hasConcept C2776882836 @default.
- W2077858580 hasConcept C2777063393 @default.
- W2077858580 hasConcept C2908834131 @default.
- W2077858580 hasConcept C2994251472 @default.
- W2077858580 hasConcept C33618052 @default.
- W2077858580 hasConcept C55493867 @default.
- W2077858580 hasConcept C71924100 @default.
- W2077858580 hasConceptScore W2077858580C118487528 @default.
- W2077858580 hasConceptScore W2077858580C185592680 @default.
- W2077858580 hasConceptScore W2077858580C202751555 @default.
- W2077858580 hasConceptScore W2077858580C203014093 @default.
- W2077858580 hasConceptScore W2077858580C2776882836 @default.
- W2077858580 hasConceptScore W2077858580C2777063393 @default.
- W2077858580 hasConceptScore W2077858580C2908834131 @default.
- W2077858580 hasConceptScore W2077858580C2994251472 @default.
- W2077858580 hasConceptScore W2077858580C33618052 @default.
- W2077858580 hasConceptScore W2077858580C55493867 @default.
- W2077858580 hasConceptScore W2077858580C71924100 @default.
- W2077858580 hasIssue "2" @default.
- W2077858580 hasLocation W20778585801 @default.
- W2077858580 hasLocation W20778585802 @default.
- W2077858580 hasOpenAccess W2077858580 @default.
- W2077858580 hasPrimaryLocation W20778585801 @default.
- W2077858580 hasRelatedWork W1011052573 @default.
- W2077858580 hasRelatedWork W2026136095 @default.
- W2077858580 hasRelatedWork W2035603658 @default.
- W2077858580 hasRelatedWork W2095247301 @default.
- W2077858580 hasRelatedWork W2186573152 @default.
- W2077858580 hasRelatedWork W2221625658 @default.
- W2077858580 hasRelatedWork W2751164993 @default.
- W2077858580 hasRelatedWork W2953961943 @default.
- W2077858580 hasRelatedWork W4233682919 @default.
- W2077858580 hasRelatedWork W4293564090 @default.
- W2077858580 hasVolume "37" @default.
- W2077858580 isParatext "false" @default.
- W2077858580 isRetracted "false" @default.
- W2077858580 magId "2077858580" @default.
- W2077858580 workType "article" @default.