FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077859892> ?p ?o ?g. }

• W2077859892 endingPage "266" @default.
• W2077859892 startingPage "260" @default.
• W2077859892 abstract "Exposure to endotoxin is known to activate hypothalamic-pituitary-adrenal (HPA) responses in both adult and neonatal animals. We have previously reported that female rat pups exhibit greater HPA responses to endotoxin challenge than males. It is unclear, however, whether observed gender differences at this early age are mediated by gonadal factors. In the present investigation we assessed the effects of neonatal gonadectomy on HPA responses to endotoxin challenge in the developing rat. On the first day of life Long-Evans rat pups were gonadectomized or subjected to sham surgery. On the third day of life the pups were injected i.p. with 0.05 mg/kgSalmonella enteritidis endotoxin. Four hours following injection, trunk blood and tissues were collected for determination of plasma hormones and median eminence corticotropin-releasing hormone (CRH) content. Intact female rat pups were found to exhibit greater plasma adrenocorticotrophic hormone (ACTH) and corticostcronc responses to endotoxin challenge compared with male animals. Plasma corticosteronc levels, both total and free steroid, were markedly altered by removal of gonads such that responding to endotoxin was elevated in males, while it was reduced in females. In contrast, ACTH responding in male pups was not altered following gonadectomy, whereas female ACTH responses were significantly reduced compared with endotoxin-treated intact controls. CRH levels in the median eminence were reduced following endotoxin challenge to an equivalent extent in both male and female pups and this effect was partially attenuated by the removal of gonadal hormones. These data suggest that sex differences in HPA responses to immune challenge may be mediated at different levels of the HPA axis. Changes in HPA responses following gonadectomy may compensate for removal of gonadal steroid immunoregulatory influences in the neonate." @default.
• W2077859892 created "2016-06-24" @default.
• W2077859892 creator A5031874509 @default.
• W2077859892 creator A5034400760 @default.
• W2077859892 creator A5035344319 @default.
• W2077859892 date "1994-06-01" @default.
• W2077859892 modified "2023-09-26" @default.
• W2077859892 title "Sex differences in hypothalamic-pituitary-adrenal responding to endotoxin challenge in the neonate: reversal by gonadectomy" @default.
• W2077859892 cites W1525898056 @default.
• W2077859892 cites W1607092491 @default.
• W2077859892 cites W1964205365 @default.
• W2077859892 cites W1967544666 @default.
• W2077859892 cites W1968304935 @default.
• W2077859892 cites W1972993926 @default.
• W2077859892 cites W1977737843 @default.
• W2077859892 cites W1985144138 @default.
• W2077859892 cites W1992213144 @default.
• W2077859892 cites W2001570522 @default.
• W2077859892 cites W2004883821 @default.
• W2077859892 cites W2012169853 @default.
• W2077859892 cites W2014570372 @default.
• W2077859892 cites W2016585055 @default.
• W2077859892 cites W2018898149 @default.
• W2077859892 cites W2023676764 @default.
• W2077859892 cites W2027057043 @default.
• W2077859892 cites W2038891029 @default.
• W2077859892 cites W2040074509 @default.
• W2077859892 cites W2045180616 @default.
• W2077859892 cites W2046123379 @default.
• W2077859892 cites W2052322312 @default.
• W2077859892 cites W2053925035 @default.
• W2077859892 cites W2054143056 @default.
• W2077859892 cites W2067539975 @default.
• W2077859892 cites W2068392981 @default.
• W2077859892 cites W2081984658 @default.
• W2077859892 cites W2085770481 @default.
• W2077859892 cites W2093152327 @default.
• W2077859892 cites W2100436346 @default.
• W2077859892 cites W2107621267 @default.
• W2077859892 cites W2124826681 @default.
• W2077859892 cites W2125762554 @default.
• W2077859892 cites W2129565658 @default.
• W2077859892 cites W2132462628 @default.
• W2077859892 cites W2133015759 @default.
• W2077859892 cites W2145890122 @default.
• W2077859892 cites W2147433143 @default.
• W2077859892 cites W2282896171 @default.
• W2077859892 cites W2319666608 @default.
• W2077859892 cites W2405138398 @default.
• W2077859892 cites W3124718557 @default.
• W2077859892 cites W4234987230 @default.
• W2077859892 cites W4249690187 @default.
• W2077859892 cites W4252947737 @default.
• W2077859892 cites W4293247451 @default.
• W2077859892 doi "https://doi.org/10.1016/0165-3806(94)90130-9" @default.
• W2077859892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7955324" @default.
• W2077859892 hasPublicationYear "1994" @default.
• W2077859892 type Work @default.
• W2077859892 sameAs 2077859892 @default.
• W2077859892 citedByCount "51" @default.
• W2077859892 countsByYear W20778598922013 @default.
• W2077859892 countsByYear W20778598922014 @default.
• W2077859892 countsByYear W20778598922018 @default.
• W2077859892 countsByYear W20778598922021 @default.
• W2077859892 countsByYear W20778598922023 @default.
• W2077859892 crossrefType "journal-article" @default.
• W2077859892 hasAuthorship W2077859892A5031874509 @default.
• W2077859892 hasAuthorship W2077859892A5034400760 @default.
• W2077859892 hasAuthorship W2077859892A5035344319 @default.
• W2077859892 hasConcept C126322002 @default.
• W2077859892 hasConcept C134018914 @default.
• W2077859892 hasConcept C2777003273 @default.
• W2077859892 hasConcept C2779067335 @default.
• W2077859892 hasConcept C2779256933 @default.
• W2077859892 hasConcept C2779279991 @default.
• W2077859892 hasConcept C2780352252 @default.
• W2077859892 hasConcept C3020528001 @default.
• W2077859892 hasConcept C46699223 @default.
• W2077859892 hasConcept C71315377 @default.
• W2077859892 hasConcept C71924100 @default.
• W2077859892 hasConcept C86803240 @default.
• W2077859892 hasConceptScore W2077859892C126322002 @default.
• W2077859892 hasConceptScore W2077859892C134018914 @default.
• W2077859892 hasConceptScore W2077859892C2777003273 @default.
• W2077859892 hasConceptScore W2077859892C2779067335 @default.
• W2077859892 hasConceptScore W2077859892C2779256933 @default.
• W2077859892 hasConceptScore W2077859892C2779279991 @default.
• W2077859892 hasConceptScore W2077859892C2780352252 @default.
• W2077859892 hasConceptScore W2077859892C3020528001 @default.
• W2077859892 hasConceptScore W2077859892C46699223 @default.
• W2077859892 hasConceptScore W2077859892C71315377 @default.
• W2077859892 hasConceptScore W2077859892C71924100 @default.
• W2077859892 hasConceptScore W2077859892C86803240 @default.
• W2077859892 hasIssue "2" @default.
• W2077859892 hasLocation W20778598921 @default.
• W2077859892 hasLocation W20778598922 @default.
• W2077859892 hasOpenAccess W2077859892 @default.
• W2077859892 hasPrimaryLocation W20778598921 @default.

• next