FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077860947> ?p ?o ?g. }

• W2077860947 endingPage "26747" @default.
• W2077860947 startingPage "26737" @default.
• W2077860947 abstract "Aberrant phosphorylation of neuronal cytoskeletal proteins is a key pathological event in neurodegenerative disorders such as Alzheimer disease (AD) and amyotrophic lateral sclerosis, but the underlying mechanisms are still unclear. Previous studies have shown that Pin1, a peptidylprolyl cis/trans-isomerase, may be actively involved in the regulation of Tau hyperphosphorylation in AD. Here, we show that Pin1 modulates oxidative stress-induced NF-H phosphorylation. In an in vitro kinase assay, the addition of Pin1 substantially increased phosphorylation of NF-H KSP repeats by proline-directed kinases, Erk1/2, Cdk5/p35, and JNK3 in a concentration-dependent manner. In vivo, dominant-negative (DN) Pin1 and Pin1 small interfering RNA inhibited epidermal growth factor-induced NF-H phosphorylation. Because oxidative stress plays an important role in the pathogenesis of neurodegenerative diseases, we studied the role of Pin1 in stressed cortical neurons and HEK293 cells. Both hydrogen peroxide (H(2)O(2)) and heat stresses induce phosphorylation of NF-H in transfected HEK293 cells and primary cortical cultures. Knockdown of Pin1 by transfected Pin1 short interference RNA and DN-Pin1 rescues the effect of stress-induced NF-H phosphorylation. The H(2)O(2) and heat shock induced perikaryal phospho-NF-H accumulations, and neuronal apoptosis was rescued by inhibition of Pin1 in cortical neurons. JNK3, a brain-specific JNK isoform, is activated under oxidative and heat stresses, and inhibition of Pin1 by Pin1 short interference RNA and DN-Pin1 inhibits this pathway. These results implicate Pin1 as a possible modulator of stress-induced NF-H phosphorylation as seen in neurodegenerative disorders like AD and amyotrophic lateral sclerosis. Thus, Pin1 may be a potential therapeutic target for these diseases." @default.
• W2077860947 created "2016-06-24" @default.
• W2077860947 creator A5022599189 @default.
• W2077860947 creator A5051882752 @default.
• W2077860947 creator A5074658926 @default.
• W2077860947 creator A5078572190 @default.
• W2077860947 creator A5080143047 @default.
• W2077860947 creator A5090823444 @default.
• W2077860947 date "2008-09-01" @default.
• W2077860947 modified "2023-10-06" @default.
• W2077860947 title "Pin1-dependent Prolyl Isomerization Modulates the Stress-induced Phosphorylation of High Molecular Weight Neurofilament Protein" @default.
• W2077860947 cites W1464385937 @default.
• W2077860947 cites W1525169050 @default.
• W2077860947 cites W1530284699 @default.
• W2077860947 cites W1541944730 @default.
• W2077860947 cites W1601155059 @default.
• W2077860947 cites W1851307228 @default.
• W2077860947 cites W1853097269 @default.
• W2077860947 cites W1965991145 @default.
• W2077860947 cites W1967024359 @default.
• W2077860947 cites W1968765684 @default.
• W2077860947 cites W1969373668 @default.
• W2077860947 cites W1970446261 @default.
• W2077860947 cites W1976231134 @default.
• W2077860947 cites W1978793039 @default.
• W2077860947 cites W1978991443 @default.
• W2077860947 cites W1985131241 @default.
• W2077860947 cites W1993351141 @default.
• W2077860947 cites W1996324631 @default.
• W2077860947 cites W1996340195 @default.
• W2077860947 cites W2000002715 @default.
• W2077860947 cites W2004209268 @default.
• W2077860947 cites W2015642465 @default.
• W2077860947 cites W2022371308 @default.
• W2077860947 cites W2025438577 @default.
• W2077860947 cites W2026258231 @default.
• W2077860947 cites W2029225256 @default.
• W2077860947 cites W2031588422 @default.
• W2077860947 cites W2038805839 @default.
• W2077860947 cites W2043035995 @default.
• W2077860947 cites W2050000741 @default.
• W2077860947 cites W2052086914 @default.
• W2077860947 cites W2056477724 @default.
• W2077860947 cites W2057019541 @default.
• W2077860947 cites W2058609749 @default.
• W2077860947 cites W2065042412 @default.
• W2077860947 cites W2073864172 @default.
• W2077860947 cites W2073921305 @default.
• W2077860947 cites W2074035248 @default.
• W2077860947 cites W2078245438 @default.
• W2077860947 cites W2086783898 @default.
• W2077860947 cites W2098132374 @default.
• W2077860947 cites W2100837269 @default.
• W2077860947 cites W2102369205 @default.
• W2077860947 cites W2105214585 @default.
• W2077860947 cites W2105856208 @default.
• W2077860947 cites W2106154817 @default.
• W2077860947 cites W2106218338 @default.
• W2077860947 cites W2110288122 @default.
• W2077860947 cites W2131783214 @default.
• W2077860947 cites W2151623956 @default.
• W2077860947 cites W2160287088 @default.
• W2077860947 cites W2163753548 @default.
• W2077860947 cites W2183271567 @default.
• W2077860947 cites W4256675099 @default.
• W2077860947 doi "https://doi.org/10.1074/jbc.m801633200" @default.
• W2077860947 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2546547" @default.
• W2077860947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18635547" @default.
• W2077860947 hasPublicationYear "2008" @default.
• W2077860947 type Work @default.
• W2077860947 sameAs 2077860947 @default.
• W2077860947 citedByCount "29" @default.
• W2077860947 countsByYear W20778609472012 @default.
• W2077860947 countsByYear W20778609472013 @default.
• W2077860947 countsByYear W20778609472014 @default.
• W2077860947 countsByYear W20778609472015 @default.
• W2077860947 countsByYear W20778609472016 @default.
• W2077860947 countsByYear W20778609472017 @default.
• W2077860947 countsByYear W20778609472020 @default.
• W2077860947 crossrefType "journal-article" @default.
• W2077860947 hasAuthorship W2077860947A5022599189 @default.
• W2077860947 hasAuthorship W2077860947A5051882752 @default.
• W2077860947 hasAuthorship W2077860947A5074658926 @default.
• W2077860947 hasAuthorship W2077860947A5078572190 @default.
• W2077860947 hasAuthorship W2077860947A5080143047 @default.
• W2077860947 hasAuthorship W2077860947A5090823444 @default.
• W2077860947 hasBestOaLocation W20778609471 @default.
• W2077860947 hasConcept C104317684 @default.
• W2077860947 hasConcept C11960822 @default.
• W2077860947 hasConcept C153911025 @default.
• W2077860947 hasConcept C154472170 @default.
• W2077860947 hasConcept C184235292 @default.
• W2077860947 hasConcept C185592680 @default.
• W2077860947 hasConcept C22615655 @default.
• W2077860947 hasConcept C2781098309 @default.
• W2077860947 hasConcept C2781264208 @default.
• W2077860947 hasConcept C2910677434 @default.
• W2077860947 hasConcept C54009773 @default.

• next