FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2077861214> ?p ?o ?g. }

• W2077861214 endingPage "101" @default.
• W2077861214 startingPage "95" @default.
• W2077861214 abstract "The direct effects of the cholesterol-lowering agents, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG CoA) reductase inhibitors, on vascular smooth muscle responsiveness were examined by incubation of isolated aorta from normocholesterolemic rats with simvastatin, atorvastatin, or pravastatin. The smooth muscle contractions caused by phenylephrine were progressively inhibited with increasing concentrations of simvastatin. Similarly, atorvastatin at the higher concentration caused decreased responses to phenylephrine. In contrast, incubation with pravastatin had no significant effect at all concentrations studied. In Ca2+-free buffer, the transient contraction caused by phenylephrine, which results from intracellular release of Ca2+, also was inhibited by simvastatin and atorvastatin but not by pravastatin. In cultured rat aortic smooth muscle cells loaded with fura-2, increases in intracellular free-Ca2+ concentration ([Ca2+]i) induced by angiotensin II were markedly inhibited in cells incubated with simvastatin and atorvastatin but not pravastatin. The inhibitory effects of simvastatin and atorvastatin were reversed by mevalonate. These findings demonstrate that inhibition of HMG CoA reductase by using simvastatin and atorvastatin, but not pravastatin, has effects on vascular smooth muscle cell responsiveness that involve alteration of Ca2+ homeostasis through a mevalonate-dependent pathway." @default.
• W2077861214 created "2016-06-24" @default.
• W2077861214 creator A5010676062 @default.
• W2077861214 creator A5057570274 @default.
• W2077861214 creator A5090128106 @default.
• W2077861214 date "1999-07-01" @default.
• W2077861214 modified "2023-10-15" @default.
• W2077861214 title "Differential Effects of Pravastatin, Simvastatin, and Atorvastatin on Ca2+ Release and Vascular Reactivity" @default.
• W2077861214 cites W1514066364 @default.
• W2077861214 cites W1964071961 @default.
• W2077861214 cites W2000432320 @default.
• W2077861214 cites W2020504510 @default.
• W2077861214 cites W2024788721 @default.
• W2077861214 cites W2037085464 @default.
• W2077861214 cites W2050439599 @default.
• W2077861214 cites W2052652237 @default.
• W2077861214 cites W2057724275 @default.
• W2077861214 cites W2064649898 @default.
• W2077861214 cites W2070682431 @default.
• W2077861214 cites W2071124826 @default.
• W2077861214 cites W2076780529 @default.
• W2077861214 cites W2078070485 @default.
• W2077861214 cites W2100142452 @default.
• W2077861214 cites W2104918389 @default.
• W2077861214 cites W2133362776 @default.
• W2077861214 cites W2141260882 @default.
• W2077861214 cites W2165527148 @default.
• W2077861214 cites W2178557511 @default.
• W2077861214 cites W2335357402 @default.
• W2077861214 cites W4241348314 @default.
• W2077861214 doi "https://doi.org/10.1097/00005344-199907000-00016" @default.
• W2077861214 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10413074" @default.
• W2077861214 hasPublicationYear "1999" @default.
• W2077861214 type Work @default.
• W2077861214 sameAs 2077861214 @default.
• W2077861214 citedByCount "56" @default.
• W2077861214 countsByYear W20778612142012 @default.
• W2077861214 countsByYear W20778612142013 @default.
• W2077861214 countsByYear W20778612142014 @default.
• W2077861214 countsByYear W20778612142016 @default.
• W2077861214 countsByYear W20778612142017 @default.
• W2077861214 countsByYear W20778612142019 @default.
• W2077861214 crossrefType "journal-article" @default.
• W2077861214 hasAuthorship W2077861214A5010676062 @default.
• W2077861214 hasAuthorship W2077861214A5057570274 @default.
• W2077861214 hasAuthorship W2077861214A5090128106 @default.
• W2077861214 hasConcept C104950815 @default.
• W2077861214 hasConcept C126322002 @default.
• W2077861214 hasConcept C134018914 @default.
• W2077861214 hasConcept C134651460 @default.
• W2077861214 hasConcept C181199279 @default.
• W2077861214 hasConcept C185592680 @default.
• W2077861214 hasConcept C2776329913 @default.
• W2077861214 hasConcept C2777320049 @default.
• W2077861214 hasConcept C2777482532 @default.
• W2077861214 hasConcept C2777952589 @default.
• W2077861214 hasConcept C2778163477 @default.
• W2077861214 hasConcept C2779395532 @default.
• W2077861214 hasConcept C2779519902 @default.
• W2077861214 hasConcept C2992686903 @default.
• W2077861214 hasConcept C55493867 @default.
• W2077861214 hasConcept C71924100 @default.
• W2077861214 hasConcept C79879829 @default.
• W2077861214 hasConcept C84393581 @default.
• W2077861214 hasConcept C98274493 @default.
• W2077861214 hasConceptScore W2077861214C104950815 @default.
• W2077861214 hasConceptScore W2077861214C126322002 @default.
• W2077861214 hasConceptScore W2077861214C134018914 @default.
• W2077861214 hasConceptScore W2077861214C134651460 @default.
• W2077861214 hasConceptScore W2077861214C181199279 @default.
• W2077861214 hasConceptScore W2077861214C185592680 @default.
• W2077861214 hasConceptScore W2077861214C2776329913 @default.
• W2077861214 hasConceptScore W2077861214C2777320049 @default.
• W2077861214 hasConceptScore W2077861214C2777482532 @default.
• W2077861214 hasConceptScore W2077861214C2777952589 @default.
• W2077861214 hasConceptScore W2077861214C2778163477 @default.
• W2077861214 hasConceptScore W2077861214C2779395532 @default.
• W2077861214 hasConceptScore W2077861214C2779519902 @default.
• W2077861214 hasConceptScore W2077861214C2992686903 @default.
• W2077861214 hasConceptScore W2077861214C55493867 @default.
• W2077861214 hasConceptScore W2077861214C71924100 @default.
• W2077861214 hasConceptScore W2077861214C79879829 @default.
• W2077861214 hasConceptScore W2077861214C84393581 @default.
• W2077861214 hasConceptScore W2077861214C98274493 @default.
• W2077861214 hasIssue "1" @default.
• W2077861214 hasLocation W20778612141 @default.
• W2077861214 hasLocation W20778612142 @default.
• W2077861214 hasOpenAccess W2077861214 @default.
• W2077861214 hasPrimaryLocation W20778612141 @default.
• W2077861214 hasRelatedWork W2013731815 @default.
• W2077861214 hasRelatedWork W2042709174 @default.
• W2077861214 hasRelatedWork W2056073416 @default.
• W2077861214 hasRelatedWork W2059347401 @default.
• W2077861214 hasRelatedWork W2112575569 @default.
• W2077861214 hasRelatedWork W2158550136 @default.
• W2077861214 hasRelatedWork W2235706673 @default.
• W2077861214 hasRelatedWork W2254876285 @default.
• W2077861214 hasRelatedWork W2356036491 @default.

• next